Abstract: The invention provides compositions and methods for treating neuropathic pain. Specifically, the disclosure provides a polynucleotide comprising a trigeminal ganglion (TGG) or dorsal root ganglion (DRG) promoter operably linked to a recombinant nucleic acid encoding an endonuclease that binds to a nucleotide sequence in the human colony stimulating factor 1 (hCSF1) gene and a method of using the polynucleotide or a vector comprising the polynucleotide for treatment of neuropathic pain.

Abstract: The invention provides compositions and methods for treating neuropathic pain. Specifically, the disclosure provides a polynucleotide comprising a trigeminal ganglion (TGG) or dorsal root ganglion (DRG) promoter operably linked to a recombinant nucleic acid encoding an endonuclease that binds to a nucleotide sequence in the human colony stimulating factor 1 (hCSF1) gene and a method of using the polynucleotide or a vector comprising the polynucleotide for treatment of neuropathic pain.

Abstract: Intrathecal delivery of a pharmaceutically acceptable formulation for intrathecal administration of any drug selectively binding to this receptor to provide pain can be used in any situation in which intrathecal (“IT”) drugs are presently used for pain management. In the preferred embodiment, the drug is a triptan. In another embodiment, a combination of drugs with triptans can be used instead of just the triptan. Exemplary conditions to be treated include cancer pain, chronic back pain, post-herpetic neuralgia, and complex regional pain syndrome types I or II, as well as post-traumatic pain, diabetic vasculopathy, inflammatory radiculopathy, inflammatory plexopathies such as brachial plexopathy (Parsonage Turner syndrome), or lumbar plexopathy, HIV neuropathy, chemotherapy-induced neuropathy (such as vincristine toxicity), erythromelalgia, and inherited painful disorders such as metachromatic leukodystrophy, Friedreich's ataxia, and Fabry's disease.