Patents by Inventor Allan Dorn

Allan Dorn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single receptor assays for immunosuppressive drugs
    Patent number: 7642059
    Abstract: A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substituted for an antibody, and a competition results between a drug conjugate and the drug analyte for a limited number of immunophilin binding sites. In a microparticle agglutination assay format, an immunophilin is either bound to a particle or in solution. In the case where an immunophilin is bound to a particle, a polyvalent conjugate of the drug analyte is present in solution.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: January 5, 2010
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gerald Sigler, Mitali Ghoshal, Allan Dorn, Shaker Rashid
  • Conjugates of mycophenolic acid
    Patent number: 7476727
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: January 13, 2009
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Mitali Ghoshal, Gerald Sigler, Raymond A. Hui, Ronald Hawley, Eva Hoess, Erasmus J. Huber, John W. Patterson, Salvatore J. Salamone, Allan Dorn
  • Recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides
    Publication number: 20080026424
    Abstract: The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type IMPDH polypeptide. The invention also relates to a method, nucleic acid molecules, vectors, and host cells for producing such a histidine-tagged, modified IMPDH polypeptide, and to kits comprising the histidine-tagged, modified IMPDH polypeptide.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 31, 2008
    Inventors: Allan Dorn, Janice Rugaber
  • Conjugates of mycophenolic acid
    Patent number: 7235675
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: June 26, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Mitali Ghoshal, Gerald Sigler, Raymond A. Hui, Ronald Hawley, Eva Hoess, Erasmus J. Huber, John W. Patterson, Salvatore J. Salamone, Allan Dorn
  • ENZYME INHIBITON IMMUNOASSAY
    Publication number: 20070142631
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
    Type: Application
    Filed: February 9, 2007
    Publication date: June 21, 2007
    Inventors: Mitali Ghoshal, Gerald Sigler, Raymond Hui, Ronald Hawley, Eva Hoess, Erasmus Huber, John Patterson, Salvatore Salamone, Allan Dorn
  • SINGLE RECEPTOR ASSAYS FOR IMMUNOSUPPRESSIVE DRUGS
    Publication number: 20070054338
    Abstract: A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substituted for an antibody, and a competition results between a drug conjugate and the drug analyte for a limited number of immunophilin binding sites. In a microparticle agglutination assay format, an immunophilin is either bound to a particle or in solution. In the case where an immunophilin is bound to a particle, a polyvalent conjugate of the drug analyte is present in solution.
    Type: Application
    Filed: August 31, 2006
    Publication date: March 8, 2007
    Inventors: Gerald Sigler, Mitali Ghoshal, Allan Dorn, Shaker Rashid
  • Modified inosine monophosphate dehydrogenases
    Publication number: 20050202520
    Abstract: The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type IMPDH polypeptide. The invention also relates to a method, nucleic acid molecules, vectors, and host cells for producing such a histidine-tagged, modified IMPDH polypeptide, and to kits comprising the histidine-tagged, modified IMPDH polypeptide.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 15, 2005
    Inventors: Allan Dorn, Janice Rugaber
  • Enzyme inhibition immunoassay
    Publication number: 20050009076
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
    Type: Application
    Filed: July 27, 2004
    Publication date: January 13, 2005
    Inventors: Mitali Ghoshal, Gerald Sigler, Raymond Hui, Ronald Hawley, Eva Hoess, Erasmus Huber, John Patterson, Salvatore Salamone, Allan Dorn
  • Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
    Patent number: 6811998
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: November 2, 2004
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Mitali Ghoshal, Gerald Sigler, Raymond A. Hui, Ronald Hawley, Eva Hoess, Erasmus J. Huber, John W. Patterson, Salvatore J. Salamone, Allan Dorn
  • Enzyme inhibition immunoassay
    Publication number: 20030207431
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.
    Type: Application
    Filed: January 14, 2003
    Publication date: November 6, 2003
    Inventors: Mitali Ghoshal, Gerald Sigler, Raymond A. Hui, Ronald Hawley, Eva Hoess, Erasmus J. Huber, John W. Patterson, Salvatore J. Salamone, Allan Dorn