Abstract: Devices, systems, and methods for applying pulsed energy to effectuate a physiological response in a human subject. Systems and methods disclosed herein can include, for example, a stimulus device that applies pulsed energy, such as heat, into a volume of tissue. The stimulus device can include one or more electrodes and can be affixed to the skin or implanted at a target site within the body. The systems and method can further include a monitoring device that detects at least one physiological parameter of the human subject during application of the pulsed energy, such as blood flow, oxygen delivery, muscle tension, subcutaneous or muscle temperatures, or brain activity. A control device can use the detected physiological parameter to define treatment parameters of the stimulus device such that the pulsed energy synchronizes with the measured physiological parameter to effectuate a desired response, such as reducing pain, suppressing appetite, and/or activating a hedonic response.

Abstract: A modular stimulus applicator system and method are disclosed. The system includes a plurality of wirelessly controlled stimulus pods configured to be anchored to a patients body, and configured to deliver stimulus to the patients body. The stimulus can be heat, vibration, or electrical stimulus, or any combination thereof. The stimulus pods can be charged by a charging station that prevents the stimulus pods from being in contact with the patients body during charging.

Abstract: Systems for controlling or aiding patient therapy are provided. The systems may include a tissue oxygenation measurement device and a therapy delivery apparatus that is controllable to assist in attaining a target tissue oxygenation level or range, whereby patient health is improved by optimizing delivery of therapy based on measured tissue oxygenation. The therapy delivery apparatus may include, for example, a drug delivery apparatus, a ventilating apparatus, a fluid delivery apparatus and/or a chest compression delivery apparatus. The tissue oxygenation measurement device may include a probe for determining the oxygenation of tissue, for example, muscle tissue, by optically interrogating the tissue. Related methods for guiding patient therapy and exercise training are also provided.

Abstract: A method for preparing an analyte-containing solution, which is compatible with surface-tension-directed liquid droplet manipulation and solid-phase affinity-based assays, is disclosed.

Abstract: A novel affinity capture surface, as well as methods of using and making the affinity capture surface and sample presentation devices or biochips comprising the affinity capture surface, are disclosed.

Abstract: A touchpad (50) having multiple regions that may be linked to various commands or functions within a graphical user interface (GUI). Preferably, a cursor control region (54), a scroll control region (56), and a pan control region (58) are defined on the touchpad. Movement of a contact point in the cursor control region causes movement of a cursor in the GUI. Movement of a contact point in the scroll control region or the pan control region causes scrolling or panning, respectively, of the workspace in the GUI. The multiple regions may be mapped onto a single touchpad member (80) or each region identified with a separate touchpad member.

Abstract: A pointing device which is removably attachable to a keyboard is disclosed. The pointing device is coupled to an attachment assembly, the attachment assembly being removably and selectively attachable to the keyboard. The attachment assembly includes a coupling assembly and a tilting assembly. The full weight of the pointing device is supported by the computer so that a work surface is not necessary. In one embodiment, a clamping assembly is provided. The clamp assembly includes a variable width clamp to permit the pointing device to be attached to any one of a number of different keyboards or in different positions on the same keyboard. The tilting assembly permits the user to select whether the pointing device is in a horizontal, vertical or other orientation. A rotatable ball of the pointing device is retained in contact with the rotation sensing encoders regardless of the orientation of the housing.

Abstract: A pointing device which is removably attachable to a keyboard is disclosed. The pointing device is coupled to an attachment assembly, the attachment assembly being removably and selectively attachable to the keyboard. The attachment assembly includes a clamp and a tilting assembly. The clamp includes a variable width clamp to permit the pointing device to be attached to any one of a number of different keyboards or in different positions on the same keyboard. The tilting assembly permits the user to select whether the pointing device is in a horizontal, vertical or other orientation. A rotatable ball of the pointing device is retained in contact with the rotation sensing encoders regardless of the orientation of the housing. The buttons for activating switches to enter commands into the computer overlap a top portion and a side portion of the pointing device. The switches are activated by a user pressing downward on the top region or inward from the side region.