Abstract: The disclosed computer-implemented methods and systems can enable simultaneous interactions with a single media item via two or more display devices. For example, the methods and systems discussed herein pair two or more display devices under the same digital content system account. Once paired, the methods and systems discussed herein enable interactions with media items via the two or more display devices. For example, the methods and systems enable a viewer to watch a media item on a first display device while scrubbing to a different playback position within the media item on a second display device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: In response to failure of an initial value transfer in a computer system, user input can be provided to choose between multiple alternative fallback options to change a value transfer processing plan. As another example, in response to failure of a single initial value transfer specified in a processing plan, a processing plan modification routine can include revising the processing plan to incorporate a fallback option allowed in processing plan rules in the computer system, where the fallback option can include multiple scheduled fallback value transfers that are each for amounts that are less than an amount of the initial value transfer. Additionally, a user interface control can be designed to receive user input to indicate selection of a value transfer option from a plurality of available value transfer options with different amounts of automation or interactivity for value transfers made according to the value transfer options.

Abstract: Machine-learning methods and apparatus are disclosed to determine critical state or other parameters related to fluid-driven failure of a terrestrial locale impacted by anthropogenic activities such as hydraulic fracturing, hydrocarbon extraction, wastewater disposal, or geothermal harvesting. Acoustic emission, seismic waves, or other detectable indicators of microscopic processes are sensed. A classifier is trained using time series of microscopic data along with corresponding data of critical state or failure events. In disclosed examples, random forests and artificial neural networks are used, and grid-search or EGO procedures are used for hyperparameter tuning. Once trained, the classifier can be applied to live data from a fluid injection locale in order to assess a frictional state, assess seismic hazard, assess permeability, make predictions regarding a future fluid-driven failure event, or drive engineering solutions for mitigation or remediation. Variations are disclosed.

Abstract: A method, device, and a vehicle information system are provided for persisting application context from the mobile device to the vehicle information system. An operating context is determined for at least one application executing on the mobile device. A user interface view for display by the vehicle information system is generated and provided to the vehicle information system. The user interface view comprises at least one application user interface element associated with the at least one application, and the application user interface element comprises an application entry point defined by the operating context for the at least one application.

Abstract: Machine-learning methods and apparatus are disclosed to determine frictional state or other parameters in an earthquake zone or other failing medium, using acoustic emission, seismic waves, or other detectable indicators of microscopic processes. Predictions of future failures are demonstrated in different regimes. A classifier is trained using time series of acoustic emission data along with historic data of frictional state or failure events. In disclosed examples, random forests and gradient boost trees are used, and grid-search or EGO procedures are used for hyperparameter tuning. Once trained, the classifier can be applied to testing or live data in order to assess a frictional state, assess seismic hazard, or make predictions regarding a future failure event. The technology has been developed in a double direct shear apparatus, but can be widely applied to seismic faults, other terrestrial failures, or failures in man-made structures. Variations are disclosed.

Abstract: Apparatus and methods for measurement of pore pressure in rock formations through an open, or cemented and/or cased, borehole are described. Such measurements are achieved using the Dynamic Acoustic Elasticity (DAE) method for characterizing nonlinear parameters by perturbing a selected rock formation volume with a High Amplitude, Low Frequency (HALF) acoustic strain wave, and probing this volume using a Low Amplitude, High Frequency (LAHF) acoustic wave. Time reversal techniques may be employed for focusing acoustic energy Into the formation in the vicinity of the pipe or open hole.

Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: The present invention is directed to new pyridinone or pyrimidinone hydroxamic acid phosphates of Formula (1) and boronates of Formula (2), stereoisomers thereof; wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation; X is CH or N; and Z is as defined herein; and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: A method, device, and a vehicle information system are provided for persisting application context from the mobile device to the vehicle information system. An operating context is determined for at least one application executing on the mobile device. A user interface view for display by the vehicle information system is generated and provided to the vehicle information system. The user interface view comprises at least one application user interface element associated with the at least one application, and the application user interface element comprises an application entry point defined by the operating context for the at least one application.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: A method, device, and a vehicle information system are provided for persisting application context from the mobile device to the vehicle information system. An operating context is determined for at least one application executing on the mobile device. A user interface view for display by the vehicle information system is generated and provided to the vehicle information system. The user interface view comprises at least one application user interface element associated with the at least one application, and the application user interface element comprises an application entry point defined by the operating context for the at least one application.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.