Patents by Inventor Allan Lihme
Allan Lihme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9220997Abstract: In the field of expanded bed adsorption chromatography, with particular but not exclusive relevance to disposable expanded bed chromatography columns, a method of conducting upward flow expanded bed chromatography comprising: supplying a liquid via an inlet to a stationary phase medium contained in a column, allowing adsorption of at least one component from the liquid by the stationary phase medium, withdrawing the liquid from the column via an outlet, regulating the expansion of the stationary phase medium by regulation of the flow rate of the liquid through at least the inlet, and restricting any overpressure in the headspace of the column to not more than the outside pressure plus 0.1 bar, is provided. In addition, apparatus for use in said method, in particular columns for use in expanded bed chromatography, are provided.Type: GrantFiled: March 28, 2008Date of Patent: December 29, 2015Assignee: DPX HOLDINGS B.V.Inventors: Allan Lihme, René Oehlenschläger Holte, Kurt Hauge Jensen, Tony Christensen
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Patent number: 9056894Abstract: The present invention relates to a method for capturing virus-like particles of interest from a mixture comprising the use of an expanded bed of adsorbent; suitably wherein said method comprises the steps of: (a) providing an expanded bed of adsorbent; (b) contacting the mixture with the adsorbent such that the constituents of the mixture contact the expanded bed of adsorbent; (c) optionally washing the adsorbent; and (d) optionally eluting the particle of interest from the adsorbent.Type: GrantFiled: October 27, 2011Date of Patent: June 16, 2015Assignee: Philip Morris Products S.A.Inventors: Allan Lihme, Karen Oishi, Inga Vaarst, Rosa Cabrera
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Publication number: 20130317197Abstract: The present invention relates to a method for capturing virus-like particles of interest from a mixture comprising the use of an expanded bed of adsorbent; suitably wherein said method comprises the steps of: (a) providing an expanded bed of adsorbent; (b) contacting the mixture with the adsorbent such that the constituents of the mixture contact the expanded bed of adsorbent; (c) optionally washing the adsorbent; and (d) optionally eluting the particle of interest from the adsorbent.Type: ApplicationFiled: October 27, 2011Publication date: November 28, 2013Applicant: PHILIP MORRIS PRODUCTS S.A.Inventors: Allan Lihme, Karen Oishi, Inga Vaarst, Rosa Cabrera
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Publication number: 20100084344Abstract: In the field of expanded bed adsorption chromatography, with particular but not exclusive relevance to disposable expanded bed chromatography columns, a method of conducting upward flow expanded bed chromatography comprising: supplying a liquid via an inlet to a stationary phase medium contained in a column, allowing adsorption of at least one component from the liquid by the stationary phase medium, withdrawing the liquid from the column via an outlet, regulating the expansion of the stationary phase medium by regulation of the flow rate of the liquid through at least the inlet, and restricting any overpressure in the headspace of the column to not more than the outside pressure plus 0.1 bar, is provided. In addition, apparatus for use in said method, in particular columns for use in expanded bed chromatography, are provided.Type: ApplicationFiled: March 28, 2008Publication date: April 8, 2010Inventors: Allan Lihme, René Oehlenschläger Holte, Kurt Hauge Jensen, Tony Christensen
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Publication number: 20070299251Abstract: The present invention provides a process for the isolation of one or more proteins) from a protein solution. The process comprising the steps of: a) providing a protein solution comprising one or more specific proteins) and having a preset pH and a preset ionic strength or conductivity, b) applying the protein solution to a packed bed or expanded bed column comprising an adsorbent, and c) obtaining one or more proteins) from the column; wherein the protein solution has been supplemented with an alcohol.Type: ApplicationFiled: June 7, 2005Publication date: December 27, 2007Inventor: Allan Lihme
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Patent number: 7226535Abstract: The invention relates to a method of distributing a liquid in the fluid bed of an up-flow or a down-flow fluid bed reactor. The invention provides efficient distribution and plug flow like fluid flow through the fluid bed where turbulence and/or back-mixing of the fluid are minimized. In accordance with the invention a fluid bed system for use in treating a fluid by contacting the fluid with a solid phase media is provided and the system includes a reactor chamber adapted to contain the solid phase media and at least one fluid distribution means adapted to distribute and/or deliver the fluid to be treated among the particles of the medium.Type: GrantFiled: September 13, 2005Date of Patent: June 5, 2007Assignee: Upfront Chromatography A/SInventors: Jurgen Hubbuch, Timothy J. Hobley, Owen R. T. Thomas, Allan Lihme, Marie B. Hansen, Morten A. Olander
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Publication number: 20070092960Abstract: The present invention provides industrial scale expanded bed adsorption process for fractionation and isolation of bio-molecules from fluids, preferably proteins from milk and whey, in a cost-effective manner. This is accomplished by operating the expanded bed column at high temperatures of at last 40° C., combined with applying flow rates greater than 1.500 cm/hour.Type: ApplicationFiled: March 19, 2004Publication date: April 26, 2007Inventors: Marie Hansen, Allan Lihme
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Publication number: 20060060536Abstract: The invention relates to a method of distributing a liquid in the fluid bed of an up-flow or a down-flow fluid bed reactor. The invention provides efficient distribution and a plug flow like fluid flow through the fluid bed where turbulence and/or back-mixing of the fluid are minimised. In accordance with the invention a fluid bed system for use in treating a fluid by contacting the fluid with a solid phase media is provided and the system comprises a reactor chamber adapted to contain the solid phase media and at least one fluid distribution means adapted to distribute and/or deliver the fluid to be treated among the particles of the medium.Type: ApplicationFiled: September 13, 2005Publication date: March 23, 2006Inventors: Jurgen Hubbuch, Timothy Hobley, Owen Thomas, Allan Lihme, Marie Hansen, Morten Olander
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Patent number: 6977046Abstract: The invention relates to a method of distributing a liquid in the fluid bed of an up-flow or a down-flow fluid bed reactor. The invention provides efficient distribution and plug flow like fluid flow through the fluid bed where turbulence and/or back-mixing of the fluid are minimized. In accordance with the invention a fluid bed system for use in treating a fluid by contacting the fluid with a solid phase media is provided and the system includes a reactor chamber adapted to contain the solid phase media and at least one fluid distribution means adapted to distribute and/or deliver the fluid to be treated among the particles of the medium.Type: GrantFiled: May 10, 2001Date of Patent: December 20, 2005Assignee: Upfront Chromatography A/SInventors: Jurgen Hubbuch, Timothy J. Hobley, Owen R. T. Thomas, Allan Lihme, Marie B. Hansen, Morten A. Olander
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Publication number: 20050249724Abstract: The present invention provides an extracorporeal adsorption method for removing harmful substances from blood in a way that is practicable in everyday clinical practice and applicable for the timely intervention to present the development of sepsis. Said extracorporeal adsorption method being effected by an adsorption column assembly where the adsorption column assembly comprising a column and an adsorption medium in the form of particles. The sedimented volume of said particles being at the most 80% of the volume of the column.Type: ApplicationFiled: July 9, 2003Publication date: November 10, 2005Inventors: Allan Lihme, Peter Heegaard
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Publication number: 20050220953Abstract: A process for isolating lactoferrin from milk or a casein-containing component or product containing lactoferrin, comprising subjecting a precipitate of casein obtained from the milk of the casein-containing component or product, with which precipitate at least part of the milk lactoferrin is associated, to a treatment with an extraction medium whereby at least part of the lactoferrin associated with the precipitate of casein is released to the medium. When lactoferrin has been released, the medium may be subjected to different types of purification operation steps. The purification operations are selected in accordance with the purity requirements of the intended specific application. Furthermore, lactoferrin and/or a composition comprising lactoferrin according to the above-mentioned process is provided.Type: ApplicationFiled: March 6, 2003Publication date: October 6, 2005Inventor: Allan Lihme
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Publication number: 20050065329Abstract: Thus, a primary aspect of the present invention relates to a method for the fractionation of a protein-containing mixture wherein the protein-containing mixture is selected from the group consisting of milk, milk derived products, milk derived raw materials, vegetable derived products, vegetable derived extracts, fruit derived products, fruit derived extracts, fish derived products, and fish derived extracts, said method comprising the steps of: a) optionally adjusting the pH of the mixture; b) applying said mixture to an adsorption column comprising an adsorbent, said adsorbent comprises a particle with at least one high density non-porous core, surrounded by a porous material, the adsorbent having a particle density of at least 1.5 g/ml and a mean particle size of at most 150 ?m; c) optionally washing the column; d) eluting at least one protein from the adsorbent.Type: ApplicationFiled: May 31, 2002Publication date: March 24, 2005Inventors: Allan Lihme, Marie Hansen, Inga Andersen, Morten Olander
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Publication number: 20040048357Abstract: The invention relates to a method of distributing a liquid in the fluid bed of an up-flow or a down-flow fluid bed reactor. The invention provides efficient distribution and a plug flow like fluid flow through the fluid bed where turbulence and/or back-mixing of the fluid are minimised. In accordance with the invention a fluid bed system for use in treating a fluid by contacting the fluid with a solid phase media is provided and the system comprises a reactor chamber adapted to contain the solid phase media and at least one fluid distribution means adapted to distribute and/or deliver the fluid to be treated among the particles of the medium.Type: ApplicationFiled: June 20, 2003Publication date: March 11, 2004Inventors: Jurgen Hubbuch, Timothy J Hobley, Ower R T Thomas, Allan Lihme, Marie B Hansen, Morten A Olander