Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Glass-ceramics exhibiting a Vickers indentation crack initiation threshold of at least 15 kgf are disclosed. These glass-ceramics may be ion exchangeable or ion exchanged. The glass-ceramics include a crystalline and amorphous phases generated by subjecting a thin precursor glass article to ceramming cycle having an average cooling rate in the range from about 10° C./minute to about 25° C./minute. In one or more embodiments, the crystalline phase may comprise at least 20 wt % of the glass-ceramics. The glass-ceramics may include ?-spodumene ss as the predominant crystalline phase and may exhibit an opacity?about 85% over the wavelength range of 400-700 nm for an about 0.8 mm thickness and colors an observer angle of 10° and a CIE illuminant F02 determined with specular reflectance included of a* between ?3 and +3, b* between ?6 and +6, and L* between 88 and 97.

Abstract: Systems and methods for automated, sequential processing of a continuous glass ribbon by conveying the glass ribbon in a ribbon travel direction, forming a score line in the glass ribbon, separating a glass sheet from the glass ribbon at the score line while supporting the glass sheet with a transfer device, lowering the glass sheet onto a conveyor, and conveying the glass sheet in a sheet travel direction differing from the ribbon travel direction. By transferring and then conveying the glass sheet in a direction differing from the ribbon travel direction (e.g., a 90 degree turn) immediately after glass sheet separation, the systems and method of the present disclosure are conducive to streamlined production of glass sheets utilizing a unique production floor footprint.

Abstract: An apparatus and method for manufacturing a glass article includes a glass delivery device that includes a delivery orifice extending in a widthwise direction and including a first edge region, a central region, and a second edge region. The apparatus and method also include a cooling mechanism proximate the delivery orifice near the first edge region and the second edge region and a heating mechanism proximate the delivery orifice near the central region.

Abstract: Apparatuses and methods are described for cooling glass forming rolls during the glass manufacturing process. The apparatus and methods mix a liquid, such as water, and a gas, such as air, to form a liquid and gas mixture that is provided to an inside surface of the glass forming rolls to dissipate heat. In some examples, the apparatus and methods control the amount of liquid and air provided to the glass forming roll based on detecting temperatures of the glass forming rolls. In some examples, a computing device automatically controls the amount of liquid and gas mixture provided to the glass forming rolls, and may further control the proportions of each of the liquid and gas to be mixed. The apparatus and methods may allow for a more consistent glass thickness across the glass sheet, as well as a reduction in glass sheet defects.

Abstract: Embodiments of a method of forming a glass article are disclosed. The methods include supplying a glass ribbon in a first direction and redirecting the glass ribbon to a second direction different from the first direction without contacting the glass ribbon with a solid material. The glass ribbon may exhibit a viscosity of less than about 108 Poise and a thickness of about 1 mm or less. Embodiments of a glass or glass-ceramic forming apparatus are also disclosed. The apparatus may include a glass feed device for supplying a glass ribbon in a first direction and a redirection system disposed underneath the glass feed device for redirecting the glass ribbon to a second direction. In one or more embodiments, the redirection system comprising at least one gas bearing system for supplying a gas film to support the glass ribbon.

Abstract: Disclosed are various methods and apparatus for forming sheet glass from molten glass whose liquidus viscosity is <5 kP. Also disclosed is a roller for receiving and cooling continuously-fed ribbon of glass whose liquidus viscosity is <5 kP onto the roller's outer surface, where the roller is configured to be maintained at a predetermined temperature and can be rotated at a predetermined speed so that the glass ribbon comes in contact with the roller for a set duration of time and rolls off the roller at the end of the set duration of time.

Abstract: A system and process for forming a curved glass laminate article is provided. The process and system utilizes a separation material, such as solid lubricating material and/or a spray applied separation material that Applicant has determined reduces bending dot formation during co-sagging shaping of glass sheets. The bending dot reduction provided by the separation materials discussed herein is particularly seen when the pair of glass sheets have significantly different thicknesses and/or viscosities from each other.

Abstract: A forming tool for use during a process of converting a glass tube into a glass container, includes a base portion comprising a fluid cavity for containing a fluid and an insertion portion extending from the base portion. The insertion portion includes an external surface sized to fit into an opening of the glass tube. In embodiments, the insertion portion comprises a fluid opening extending from an interior surface thereof to the external surface, the fluid opening configured to deliver the fluid from the fluid cavity between the insertion portion and the glass tube. In embodiments, the forming tool comprises a thermally conductive insert extending through the base portion and the insertion portion, the thermally conductive insert extending through the fluid cavity such that the fluid in the fluid cavity regulates a temperature of the thermally conductive insert.

Abstract: Disclosed are apparatuses and methods for non-contact processing a substrate, for example a glass substrate, overtop a gas layer. The support apparatus includes a plurality of gas bearings positioned on a pressure box supplied with a pressurized gas. Some embodiments are directed to a method of supporting and transporting softened glass. The method includes placing the glass in proximity to a gas bearing device having a support surface with a plurality of outlet ports disposed therein. Some embodiments are directed to a glass processing apparatus comprising an air table configured to continuously transport and support a stream of glass and a plurality of modular devices supported by a support structure and disposed above the air table. Some embodiments are directed to a method for flattening viscous glass using a two-sided gas bearing device or a one-sided gas bearing device.

Abstract: Disclosed are apparatuses and methods for non-contact processing a substrate, for example a glass substrate, overtop a gas layer. The support apparatus includes a plurality of gas bearings positioned on a pressure box supplied with a pressurized gas. Some embodiments are directed to a method of supporting and transporting softened glass. The method includes placing the glass in proximity to a gas bearing device having a support surface with a plurality of outlet ports disposed therein. Some embodiments are directed to a glass processing apparatus comprising an air table configured to continuously transport and support a stream of glass and a plurality of modular devices supported by a support structure and disposed above the air table. Some embodiments are directed to a method for flattening viscous glass using a two-sided gas bearing device or a one-sided gas bearing device.

Abstract: A method, apparatus and computer program product modify messaging behavior based upon parsing and different processing of different portions of a request. In a method, a request is received that includes a first and second differently formatted portions. The method parses the request to separately identify the first and second portions, analyzes the second portion of the request and causes a message based at least in part upon the first portion to be transmitted to a request processor. Based upon the message including the first portion, the method receives a response from the request processor. Based upon the response from the claims processor, the method causes a response to the request to be provided. The message to the request processor or the response to request is modified or an additional message to another entity is transmitted based upon an analysis of the second portion of the request.

Abstract: Methods for producing glass articles from laminated glass tubing include introducing the glass tubing to a converter. The glass tubing includes a core layer under tensile stress, an outer clad layer under, and an inner clad layer. The methods include forming a feature the glass article at a working end of the laminated glass tubing and separating a glass article from the working end of the laminated glass tubing, which may expose the core layer under tensile stress at the working end of the glass tubing. The method further comprises remediating the exposed portion of the core layer by completely enclosing the core layer in a clad layer. Systems for re-cladding the exposed portion of the core layer as well as glass articles made using the systems and methods are also disclosed.

Abstract: A system and method of sanitizing a package left at a doorstep safely reduces exposure to pathogens with packages. The method includes a computerized doorbell, at least one motion detector, at least one ultraviolet device, and a user (PC) personal computing device. The method begins by scanning a surrounding area of the doorway with the motion detector in order to identify at least one physical package. A delivery notification for the physical package is relayed from the motion detector, through the computerized doorbell, and to the user PC device. The delivery notification is displayed for the physical package with the motion detector. The surrounding area is further scanned with the motion detector in order to identify a human presence within the surrounding area. Ultraviolet radiation is emitted onto the surrounding area for a specified time period with the ultraviolet device, if the physical package is identified within the surrounding area.

Abstract: Glass manufacturing apparatus can comprise a laser apparatus defining a laser path intersecting an outer peripheral surface of a roll. In some embodiments, methods of cleaning a roll of a glass manufacturing apparatus can comprise irradiating a target location on surface material formed on the roll with a laser beam and producing a relative movement between the roll and the target location while removing a portion of the surface material from an area of the outer peripheral surface of the roll with the laser beam. In some embodiments, methods of manufacturing a glass ribbon can comprise passing glass-forming material through a gap defined between first and second rotating rolls and removing surface material from an area of an outer peripheral surface of the first roll with a first laser beam.

Abstract: Methods for producing glass articles from laminated glass tubing include introducing the glass tubing to a converter. The glass tubing includes a core layer under tensile stress, an outer clad layer under, and an inner clad layer. The methods include forming a feature the glass article at a working end of the laminated glass tubing and separating a glass article from the working end of the laminated glass tubing, which may expose the core layer under tensile stress at the working end of the glass tubing. The method further comprises remediating the exposed portion of the core layer by completely enclosing the core layer in a clad layer. Systems for re-cladding the exposed portion of the core layer as well as glass articles made using the systems and methods are also disclosed.

Abstract: A wearable sanitization device can be conveniently carried on one's body, especially the wrist. The preferred form of the apparatus involves a rubber or flexible plastic holster in the shape of a watch. A band connected to the holster may be adjusted to fit the shape and size of a user's wrist. A sanitizer-storing receptacle is mounted within the holster, thereby reducing the likelihood of misplacing sanitizer. A dispenser extending from the receptacle is oriented towards the hand of the user, ensuring the contents of the receptacle are dispensed appropriately upon the user's palm and fingers. An exposed actuator, usually a button, on the receptacle may be depressed or actuated to enable easy, single-digit dispensing of the sanitizer. This also enables the apparatus to disperse hand sanitizer without having to be removed, thereby further preventing the apparatus from being misplaced and rendering two-hand handling of a sanitizer bottle obsolete.

Abstract: A slot orifice design that delivers glass ribbon at a uniform temperature and flow across the slot orifice width is provided. The slot orifice design can include a transition section, a pressure tank, and a slot extension.

Abstract: A molding apparatus for forming a glass article comprises a mold shell comprising a cooling surface comprising at least a first zone and a second zone; an adjustable nozzle system comprising a mold-facing surface having a plurality of apertures sized to receive a nozzle or a plug; a plurality of nozzles, each coupled to one of the apertures to direct a stream of fluid onto the cooling surface; and a fluid supply providing a fluid through the plurality of nozzles. The fluid is jetted through the nozzles to impinge against the first zone or the second zone of the cooling surface, and a number of nozzles through which the fluid is jetted to impinge against the first zone of the cooling surface is different than a number of nozzles through which the fluid is jetted to impinge against the second zone of the cooling surface.