Abstract: A conjugate of an antibody and a functional substance or a salt thereof, which comprises a structural unit represented by the following formula (I): wherein Ig represents an immunoglobulin unit comprising two heavy chains and two light chains, and regioselectively forms an amide bond with a carbonyl group adjacent to Ig via an amino group in side chains of lysine residues in the two heavy chains, L1 and L2 each represent a divalent group, R1 represents a monovalent group optionally comprising a hydrophilic group, X represents a predetermined divalent group, D represents a functional substance, RA represents a side chain of a valine residue, RB represents a side chain of a citrulline residue or an alanine residue, n is 0 or 1, and an average ratio r of the amide bonds per two heavy chains is 1.5 to 2.

Abstract: An electrochemical method for measuring the activity of enzymes using nanoelectrode arrays fabricated with vertically aligned carbon nanofibers. Short peptide substrates specific to disease-related enzymes are covalently attached to the exposed nanofiber tips. A redox moiety, such as ferrocene, can be linked at the distal end of the nanofibers. Contact of the arrays with a biological sample containing one or more target enzymes results in cleavage of the peptides and changes the redox signal of the redox moiety indicating the presence of the target enzymes.

Abstract: An electrochemical method for measuring the activity of enzymes using nanoelectrode arrays fabricated with vertically aligned carbon nanofibers. Short peptide substrates specific to disease-related enzymes are covalently attached to the exposed nanofiber tips. A redox moiety, such as ferrocene, can be linked at the distal end of the nanofibers. Contact of the arrays with a biological sample containing one or more target enzymes results in cleavage of the peptides and changes the redox signal of the redox moiety indicating the presence of the target enzymes.

Abstract: A dynamic gauntlet including at least two of a base, a hand piece, and a thumb piece. At least one of the base, hand piece and thumb piece is constructed of an elastomeric material and includes an anchor having an attachment element extending toward the at least one other of the base, hand piece and thumb piece, which includes an attachment area. The attachment element is secured to the attachment area in a variety of pre-selected locations, thereby providing variable tension in the anchor to reconfigure the hand or digits. A method of the invention includes applying at least two of the base, the hand piece and the thumb piece to a wrist, arm or hand, and securing an anchor attachment element of one or more of these components to a pre-selected location on an attachment area of these components to reconfigure the hand or digits in a desired configuration.