Patents by Inventor Allan R. Brasier
Allan R. Brasier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965881Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.Type: GrantFiled: March 24, 2017Date of Patent: April 23, 2024Assignees: Kansas State University Research Foundation, Board of Regents of The University of Texas SystemInventors: Massoud Motamedi, Allan R. Brasier, Stefan H. Bossmann, Christopher T. Culbertson, Deryl Troyer
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Patent number: 11117865Abstract: Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.Type: GrantFiled: June 16, 2019Date of Patent: September 14, 2021Assignee: Board of Regents, The University Of Texas SystemInventors: Jia Zhou, Allan R. Brasier, Bing Tian, Zhiqing Liu, Haiying Chen, Erik Rytting
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Publication number: 20210063394Abstract: Certain embodiments are directed to detection methods and methods of identifying detection targets for sensitive and specific laboratory tests to diagnose and monitor rickettsial infections during the earliest stages of the disease and to assess the degree of illness.Type: ApplicationFiled: August 27, 2020Publication date: March 4, 2021Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Allan R. BRASIER, Yingxin ZHAO, David H. WALKER, Rong FANG
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Publication number: 20200300849Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.Type: ApplicationFiled: March 24, 2017Publication date: September 24, 2020Inventors: Massoud Motamedi, Allan R. Brasier, Stefan H. Bossmann, Christopher T. Culbertson, Deryl Troyer
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Publication number: 20190359573Abstract: Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.Type: ApplicationFiled: June 16, 2019Publication date: November 28, 2019Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Jia ZHOU, Allan R. BRASIER, Bing TIAN, Zhiqing LIU, Haiying CHEN, Erik RYTTING
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Patent number: 9834770Abstract: DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.Type: GrantFiled: March 30, 2015Date of Patent: December 5, 2017Assignee: Board of Regents, The University of Texas SystemInventors: Steven G. Widen, Thomas G. Wood, Allan R. Brasier, Yingxin Zhao
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Publication number: 20150259687Abstract: DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.Type: ApplicationFiled: March 30, 2015Publication date: September 17, 2015Inventors: Steven G. Widen, Thomas G. Wood, Allan R. Brasier, Yingxin Zhao
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Patent number: 9018367Abstract: DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.Type: GrantFiled: April 12, 2012Date of Patent: April 28, 2015Assignee: Board of Regents, The University of Texas SystemInventors: Steven G. Widen, Thomas G. Wood, Allan R. Brasier, Yingxin Zhao
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Publication number: 20120263651Abstract: DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.Type: ApplicationFiled: April 12, 2012Publication date: October 18, 2012Applicant: Board of Regents, The University of Texas SystemInventors: Steven G. Widen, Thomas G. Wood, Allan R. Brasier, Yingxin Zhao
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Patent number: 8053199Abstract: The present invention discloses a method for classifying individuals into those who have airway hyperreactvitiy and those with asthma based on cytokine expression patterns. It is contemplated that such a method will enable rapid identification of individuals requiring intensive treatment for asthma, thereby reducing morbidity and improving quality of life for those affected.Type: GrantFiled: July 22, 2008Date of Patent: November 8, 2011Inventors: Allan R. Brasier, William J. Calhoun, Gary D. Boetticher
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Patent number: 7521534Abstract: Disclosed are isolated IKK??; isolated nucleic acid molecules encoding IKK??; expression vectors and cells which contain such nucleic acid molecules; oligonucleotides which are complementary to at least a portion of nucleic acid molecules encoding IKK?? but which are not complementary to any portion of nucleic acid molecules encoding wild type IKK?; antibodies which are specific for IKK??; DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKK??; and DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKK?? but which do not hybridize with nucleic acid molecules encoding wild type IKK?. Methods for using these materials to inhibit formation of IKK??-containing IKK, to inhibit NF-?B activation, and to treat or prevent inflammation are also disclosed.Type: GrantFiled: March 3, 2004Date of Patent: April 21, 2009Assignee: The University Board of Regents of Texas SystemInventors: Allan R. Brasier, Tao Hai, Thomas G. Wood, Yuanfen Wei
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Publication number: 20090068689Abstract: The present invention discloses a method for classifying individuals into those who have airway hyperreactvitiy and those with asthma based on cytokine expression patterns. It is contemplated that such a method will enable rapid identification of individuals requiring intensive treatment for asthma, thereby reducing morbidity and improving quality of life for those affected.Type: ApplicationFiled: July 22, 2008Publication date: March 12, 2009Inventors: Allan R. Brasier, William J. Calhoun, Gary D. Boetticher
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Patent number: 7179894Abstract: A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The modified nucleotides are incorporated during PCR amplification to form achiral modified oligonucleotides. Thio-substituted aptamers are provided that bind tightly to the nuclear factor for human IL6 (NF-IL6).Type: GrantFiled: April 11, 2002Date of Patent: February 20, 2007Assignee: Board of Regents, The University of Texas SystemInventors: David G. Gorenstein, David J. King, Daniel A. Ventura, Allan R. Brasier
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Patent number: 6699459Abstract: The present invention relates to a method of treating lung inflammation in a subject which includes administering butylated hydroxyanisol to the subject in an amount effective to treat lung inflammation. The invention also relates to methods of inhibiting interferon regulatory factor activation in a subject and in an alveolar cell. Another aspect of the invention relates to an assay.Type: GrantFiled: March 1, 2002Date of Patent: March 2, 2004Assignee: The Board of Regents of the University of Texas SystemInventors: Antonella Casola, Roberto Garofalo, Allan R. Brasier
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Publication number: 20030012736Abstract: The present invention relates to a method of treating lung inflammation in a subject which includes administering butylated hydroxyanisol to the subject in an amount effective to treat lung inflammation. The invention also relates to methods of inhibiting interferon regulatory factor activation in a subject and in an alveolar cell. Another aspect of the invention relates to an assay.Type: ApplicationFiled: March 1, 2002Publication date: January 16, 2003Inventors: Antonella Casola, Roberto Garofalo, Allan R. Brasier
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Patent number: 6423493Abstract: A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The modified nucleotides are incorporated during PCR amplification to form achiral modified oligonucleotides. Thio-substituted aptamers are provided that bind tightly to the nuclear factor for human IL6 (NF-IL6).Type: GrantFiled: October 25, 1999Date of Patent: July 23, 2002Assignee: Board of Regents the University of Texas SystemInventors: David G. Gorenstein, David J. King, Daniel A. Ventura, Allan R. Brasier
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Patent number: 5804445Abstract: The present invention relates to inhibitors of the sequence specific transcription factor nuclear factor IL-6 (NF-IL6) and methods of use therefor. In particular, substitution mutants in the N-terminus of the NF-IL6 tryptic core domain are disclosed that have a higher binding affinity for the DNA binding site than does the wild-type sequence.Type: GrantFiled: January 11, 1996Date of Patent: September 8, 1998Assignee: Board of Regents, The University of Texas SystemInventor: Allan R. Brasier