Abstract: Provided herein are compounds and compositions that inhibit telomerase and/or the TERT gene with a mutant promoter. Further provided are small molecule compounds or compositions having beneficial effects in cancer treatment. Methods of making the compounds and compositions and methods of using the compounds and compositions, such as using the compounds and compositions to treat cancer, are also provided.

Abstract: The present application relates to a method for determining multiple simultaneous fault conditions on complex systems. The method comprises receiving symptoms of a complex system from monitors. When some of the symptoms suggest the existence of multiple simultaneous fault conditions, then the method creates a symptom signature, creates one or more failure mode signatures, and creates an error code for each failure mode signature in regard to the symptom signature. Each failure mode signature is associated with only one failure mode. A Hamming distance is determined for each failure mode indicated as possibly causing the original fault condition. Each failure mode with the minimum Hamming distance and same Hamming Code are grouped together as being one of the multiple simultaneous fault conditions. All remaining failure modes with other Hamming distances are then assigned into one of the simultaneous fault conditions.

Abstract: A system and method for providing remote access to an on-board aircraft system provides establishing communication between an aircraft server that is located within the aircraft and a remote computer that is located outside of the aircraft. In the aircraft, a request is received to establish a remote session between the remote computer and the aircraft server. A passcode is generated in the aircraft, and is transmitted from a first communication device that is collocated with the aircraft to a second communication device that is collocated with the remote computer. The passcode is then transmitted from the remote computer to the aircraft server and, upon receipt of the passcode by the aircraft server, the remote computer is provided with remote access to the on-board aircraft system.

Abstract: A method for accumulating fault condition data from a hierarchical system is presented comprising monitoring an operation of a component with a computing node that includes a processor and a memory. The memory contains a configuration file comprising failure modes (FM), symptoms, tests that identify the symptoms and a corrective action for the symptom. The method further comprises populating at least one of the processor and the memory of the computing node with one or more standardized executable application modules (SEAM) and a workflow service. The one or more SEAMS is configured to create a fault condition record by collecting all FMs that manifest the symptom. For all FMs collected, a list of unique symptoms is produced. Further all tests that can identify the listed unique symptoms and all of the corrective actions associated with the FMs that manifest the symptom are determined from the memory device.

Abstract: The present application relates to a method for determining multiple simultaneous fault conditions on complex systems. The method comprises receiving symptoms of a complex system from monitors. When some of the symptoms suggest the existence of multiple simultaneous fault conditions, then the method creates a symptom signature, creates one or more failure mode signatures, and creates an error code for each failure mode signature in regard to the symptom signature. Each failure mode signature is associated with only one failure mode. A Hamming distance is determined for each failure mode indicated as possibly causing the original fault condition. Each failure mode with the minimum Hamming distance and same Hamming Code are grouped together as being one of the multiple simultaneous fault conditions. All remaining failure modes with other Hamming distances are then assigned into one of the simultaneous fault conditions.

Abstract: A handheld electronic pipette including several features aimed at improving ease of use, including a color dot matrix display, an intuitive thumb-operated two-axis controller, and multifunction soft buttons adjacent to the display. A simple and consistent user interface facilitates easy access to various modes of operation, including a manual pipetting mode and a remote mode.

Abstract: Systems and methods are provided for customizing workflow in a condition based health maintenance (“CBM”) system computing node. The computerized method comprises identifying a first standardized executable application module (“SEAM”), wherein the first SEAM is configured to generate a first event associated with particular data being processed by the first SEAM and identifying a second SEAM, wherein the second SEAM is configured to generate a subsequent event associated with the particular data processed by the first SEAM. The computerized method further comprises creating a quasi-state machine associating a unique responses to the first event and associating a unique responses to the subsequent event, and installing the quasi-state machine into the SDS of the computing node from which the workflow service state machine retrieves the one or more unique responses from the quasi-state machine to the first event for processing by the second SEAM to produce the subsequent second event.

Abstract: A method of operating a turbine engine system and a turbine engine system are provided. The method comprises supplying a flow of oxygen to a combustion chamber defined within a plurality of turbines coupled serially together within the turbine engine system, supplying a flow of hydrocarbonaccous fuel to the combustion chambers of each of the plurality of turbines in the turbine engine system, and supplying a working fluid to an inlet of a first turbine engine coupled within the turbine engine system, wherein the working fluid is substantially nitrogen-free and wherein each of the turbines coupled within the turbine engine system is operable with the resulting fuel-oxygen-working fluid mixture.

Abstract: Methods and reconfigurable systems are provided for monitoring the health of a complex system. The reconfigurable system comprises a plurality of standardized executable application modules containing instructions to perform one of a plurality of different standardized functions. The system further comprises a plurality of computing nodes arranged in a hierarchical structure comprising one or more layers of computing nodes. Each computing node of the plurality runs a host application and a workflow service module, each computing node thereby being configured by a configuration file that directs the execution of any of the standardized executable application modules in a cooperative fashion by the host application via the workflow service module.

Abstract: A method for distributed diagnostic reasoning is provided. The method includes establishing a computing node monitoring the operation of a component of a complex system and populating at least one of a processor and the memory of the computing node with one or more standardized executable application modules (SEAMs) and a workflow service. The method further includes creating a configuration file in combination with several SEAMS to create a distributed diagnostic reasoner (DDR) associated with the component. The method also comprises installing the configuration file in the computing node for execution by the processor; and initializing the one or more SEAMS, the configuration file and the workflow service, wherein the workflow service facilitates data flow between the one or more SEAMS and the static data associated with a fault condition resident in the configuration file.

Abstract: A method for accumulating fault condition data from a hierarchical system is presented comprising monitoring an operation of a component with a computing node that includes a processor and a memory. The memory contains a configuration file comprising failure modes (FM), symptoms, tests that identify the symptoms and a corrective action for the symptom. The method further comprises populating at least one of the processor and the memory of the computing node with one or more standardized executable application modules (SEAM) and a workflow service. The one or more SEAMS is configured to create a fault condition record by collecting all FMs that manifest the symptom. For all FMs collected, a list of unique symptoms is produced. Further all tests that can identify the listed unique symptoms and all of the corrective actions associated with the FMs that manifest the symptom are determined from the memory device.

Abstract: Systems and methods are provided for customizing workflow in a condition based health maintenance (“CBM”) system computing node. The computerized method comprises identifying a first standardized executable application module (“SEAM”), wherein the first SEAM is configured to generate a first event associated with particular data being processed by the first SEAM and identifying a second SEAM, wherein the second SEAM is configured to generate a subsequent event associated with the particular data processed by the first SEAM. The computerized method further comprises creating a quasi-state machine associating a unique responses to the first event and associating a unique responses to the subsequent event, and installing the quasi-state machine into the SDS of the computing node from which the workflow service state machine retrieves the one or more unique responses from the quasi-state machine to the first event for processing by the second SEAM to produce the subsequent second event.

Abstract: Systems and Methods are provided for coordinating computing functions to accomplish a task. The system includes a plurality of standardized executable application modules (SEAMs), each of which is configured to execute on a processor to provide a unique function and to generate an event associated with its unique function. The system includes a configuration file that comprises a dynamic data store (DDS) and a static data store (SDS). The DDS includes an event queue and one or more response queues. The SDS includes a persistent software object that is configured to map a specific event from the event queue to a predefined response record and to indicate a response queue into which the predefined response record is to be placed. The system further includes a workflow service module, the work flow service module being configured to direct communication between the SDS, the DDS and each of the plurality of SEAMs.

Abstract: Systems and Methods are provided for coordinating computing functions to accomplish a task. The system includes a plurality of standardized executable application modules (SEAMs), each of which is configured to execute on a processor to provide a unique function and to generate an event associated with its unique function. The system includes a configuration file that comprises a dynamic data store (DDS) and a static data store (SDS). The DDS includes an event queue and one or more response queues. The SDS includes a persistent software object that is configured to map a specific event from the event queue to a predefined response record and to indicate a response queue into which the predefined response record is to be placed. The system further includes a workflow service module, the work flow service module being configured to direct communication between the SDS, the DDS and each of the plurality of SEAMs.

Abstract: Systems and methods for optimizing viral marketing efforts are disclosed in which a trial a viral marketing trial program is presented to a user. The viral marketing trial program includes a user incentive as well as a plurality of user tasks that needs to be completed to receive the user incentive. One or more user reactions to the plurality of user tasks are monitored; user feedback in accordance with the one or more user reactions is collected, the user feedback is analyzed using one or more metrics and the viral marketing trial program is adjusted in accordance with the analyzed user feedback.

Abstract: Systems and Methods are provided for coordinating computing functions to accomplish a task. The system includes a plurality of standardized executable application modules (SEAMs), each of which is configured to execute on a processor to provide a unique function and to generate an event associated with its unique function. The system includes a configuration file that comprises a dynamic data store (DDS) and a static data store (SDS). The DDS includes an event queue and one or more response queues. The SDS includes a persistent software object that is configured to map a specific event from the event queue to a predefined response record and to indicate a response queue into which the predefined response record is to be placed. The system further includes a workflow service module, the work flow service module being configured to direct communication between the SDS, the DDS and each of the plurality of SEAMs.

Abstract: A method for distributed diagnostic reasoning is provided. The method includes establishing a computing node monitoring the operation of a component of a complex system and populating at least one of a processor and the memory of the computing node with one or more standardized executable application modules (SEAMs) and a workflow service. The method further includes creating a configuration file in combination with several SEAMS to create a distributed diagnostic reasoner (DDR) associated with the component. The method also comprises installing the configuration file in the computing node for execution by the processor; and initializing the one or more SEAMS, the configuration file and the workflow service, wherein the workflow service facilitates data flow between the one or more SEAMS and the static data associated with a fault condition resident in the configuration file.

Abstract: A computer implemented method of improving the performance of a viral marketing program comprises exposing, via a computer network, a first offered incentive to a first plurality of users. A first consumer viral marketing action is to be completed to receive the first incentive. First data indicative of the first plurality of users' progress toward achieving the first action is collected thereby providing a likelihood of the first incentive obtaining an objective. A second incentive is exposed to a second plurality of users. A second consumer viral marketing action is to be completed to receive the second incentive. Second data indicative of the second plurality of users' progress toward achieving the second marketing action is collected thereby providing a likelihood of the second incentive obtaining the objective. The first and second data is compared using a metric to identify which incentive is more likely to obtain the objective.

Abstract: A computer implemented method of improving the performance of a viral marketing program comprises exposing, via a computer network, a first offered incentive to a first plurality of users. A first consumer viral marketing action is to be completed to receive the first incentive. First data indicative of the first plurality of users' progress toward achieving the first action is collected thereby providing a likelihood of the first incentive obtaining an objective. A second incentive is exposed to a second plurality of users. A second consumer viral marketing action is to be completed to receive the second incentive. Second data indicative of the second plurality of users' progress toward achieving the second marketing action is collected thereby providing a likelihood of the second incentive obtaining the objective. The first and second data is compared using a metric to identify which incentive is more likely to obtain the objective.

Abstract: A handheld electronic pipette including several features aimed at improving ease of use, including a color dot matrix display, an intuitive thumb-operated two-axis controller, and multifunction soft buttons adjacent to the display. A simple and consistent user interface facilitates easy access to various modes of operation, including a manual pipetting mode and a remote mode.