Patents by Inventor Allen Borchardt

Allen Borchardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE SYNTHESIS OF PROTEIN-DRUG CONJUGATES
    Publication number: 20240024497
    Abstract: The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.
    Type: Application
    Filed: August 6, 2021
    Publication date: January 25, 2024
    Inventors: Allen BORCHARDT, Robert Michael HUGHES
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20230398226
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
    Type: Application
    Filed: August 15, 2022
    Publication date: December 14, 2023
    Inventors: Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Thanh LAM, Leslie W. TARI
  • Compositions and methods for the treatment of viral infections
    Patent number: 11833213
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: December 5, 2023
    Assignee: Cidara Therapeutics, Inc.
    Inventors: James M. Balkovec, Daniel C. Bensen, Allen Borchardt, Thomas P. Brady, Zhi-Yong Chen, Jason Cole, Quyen-Quyen Thuy Do, Simon Doehrmann, Wanlong Jiang, Thanh Lam, Alain Noncovich, Leslie W. Tari
  • METHODS FOR THE SYNTHESIS OF PROTEIN-DRUG CONJUGATES
    Publication number: 20230364251
    Abstract: The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.
    Type: Application
    Filed: August 6, 2021
    Publication date: November 16, 2023
    Inventors: Allen BORCHARDT, Robert Michael HUGHES
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20230190950
    Abstract: Compositions and methods for the treatment of bacterial infections include conjugates containing an Fc domain covalently linked to one or more monomers of cyclic heptapeptides or one or more dimers of cyclic heptapeptides. In particular, conjugates can be used in the treatment of bacterial infections caused by Gram-negative bacteria.
    Type: Application
    Filed: December 20, 2017
    Publication date: June 22, 2023
    Inventors: Suzanne AKERS-RODRIGUEZ, James Michael BALKOVEC, Daniel C. BENSEN, Timothy BLIZZARD, Allen BORCHARDT, Thomas Patrick BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Joanne M. FORTIER, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20230165970
    Abstract: Compositions and methods for the treatment of bacterial infections include conjugates containing an Fc domain covalently linked to one or more monomers of cyclic heptapeptides or one or more dimers of cyclic heptapeptides. In particular, conjugates can be used in the treatment of bacterial infections caused by Gram-negative bacteria.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 1, 2023
    Inventors: Suzanne AKERS-RODRIGUEZ, James M. BALKOVEC, Daniel C. BENSEN, Timothy BLIZZARD, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Joanne M. FORTIER, Wanlong JIANG, Thanh LAM, James LEVIN, Alain NONCOVICH, Leslie W. TARI
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS
    Publication number: 20230082611
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., RSV infections).
    Type: Application
    Filed: June 12, 2020
    Publication date: March 16, 2023
    Inventors: Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Travis James HAUSSENER, Alain NONCOVICH, Leslie W. TARI
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS
    Publication number: 20230079107
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral gp120 receptor (e.g., temsavir, BMS-818251, DMJ-ll-121, BNM-IV-147, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., HIV infections).
    Type: Application
    Filed: June 12, 2020
    Publication date: March 16, 2023
    Inventors: Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Wanlong JIANG, Leslie W. TARI
  • Compositions and methods for the treatment of viral infections
    Patent number: 11510992
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: November 29, 2022
    Assignee: Cidara Therapeutics, Inc.
    Inventors: Allen Borchardt, Thomas P. Brady, Zhi-Yong Chen, Thanh Lam, Leslie W. Tari
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20220257787
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
    Type: Application
    Filed: April 21, 2021
    Publication date: August 18, 2022
    Inventors: James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20210228727
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
    Type: Application
    Filed: March 5, 2021
    Publication date: July 29, 2021
    Applicants: Cidara Therapeutics, Inc., Cidara Therapeutics, Inc.
    Inventors: James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20210220478
    Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
    Type: Application
    Filed: March 5, 2021
    Publication date: July 22, 2021
    Applicant: Cidara Therapeutics, Inc.
    Inventors: James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
  • Tricyclic Gyrase inhibitors
    Patent number: 10865216
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: December 15, 2020
    Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Allen Borchardt, Zhiyong Chen, John M. Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Leslie William Tari, Min Teng, Michael Trzoss, Junhu Zhang, Michael E. Jung, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
  • TRICYCLIC GYRASE INHIBITORS
    Publication number: 20150246934
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Application
    Filed: September 11, 2013
    Publication date: September 3, 2015
    Inventors: Daniel Bensen, Allen Borchardt, Zhiyong Chen, John M. Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Leslie William Tari, Min Teng, Michael Trzoss, Junhu Zhang, Michael E. Jung, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
  • Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease
    Patent number: 8569300
    Abstract: The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: October 29, 2013
    Assignee: Kalypsys Inc.
    Inventors: Allen Borchardt, Robert Davis, Stewart A. Noble
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110257137
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 10, 2011
    Publication date: October 20, 2011
    Applicant: KALYPSYS, INC.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Becker, Daniel Gamache, Stewart A. Noble, Mark Hellberg, Peter Klimko, Zhihai Qiu, Joseph Payne, John Yanni
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110237599
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 29, 2011
    Applicant: Kalypsys, Inc.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Gamache, Mark Hellberg, Peter Klimko, John Yanni
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110237565
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 10, 2011
    Publication date: September 29, 2011
    Applicant: KALYPSYS, INC.
    Inventors: Allen Borchardt, Robert Davis, Stewart A. Noble
  • Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
    Patent number: 7473790
    Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Allen Borchardt, Javier Gonzalez, Hui Li, Maria Angelica Linton, John Howard Tatlock
  • BENZOTHIOPHENE INHIBITORS OF RHO KINASE
    Publication number: 20080021026
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 24, 2008
    Inventors: Mehmet Kahraman, Allen Borchardt, Travis Cook, Robert Davis, Elisabeth Gardiner, James Malecha, Stewart Noble, Thomas Prins