Patents by Inventor Allen Burge
Allen Burge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9114383Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods of storing columns in a wet state.Type: GrantFiled: August 17, 2004Date of Patent: August 25, 2015Assignee: PhyNexus, Inc.Inventors: Douglas T. Gjerde, Ronald Jones, Allen Burge, Christopher P. Hanna, Leon S. Yengoyan
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Publication number: 20120164750Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the extraction columns are comprised of frits having a low pore volume. In some embodiments, the frits of the extraction columns have a pore volume of less than one microliter or less than 10% of the interstitial volume of the bed of extraction media.Type: ApplicationFiled: March 2, 2012Publication date: June 28, 2012Inventors: Douglas T. Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Patent number: 8148168Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the extraction columns are comprised of frits having a low pore. In some embodiments, the frits of the extraction columns have a pore volume of less than one microliter or less than 10% of the interstitial volume of the bed of extraction media.Type: GrantFiled: July 15, 2010Date of Patent: April 3, 2012Assignee: PhyNexus, Inc.Inventors: Douglas T. Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Patent number: 8148169Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the method involves adjusting the head pressure of the column during the process, or otherwise controlling or regulating the head pressure.Type: GrantFiled: April 21, 2011Date of Patent: April 3, 2012Assignee: PhyNexus, Inc.Inventors: Douglas T. Gjerde, Ronald Jones, Allen Burge
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Publication number: 20110192797Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the method involves adjusting the head pressure of the column during the process, or otherwise controlling or regulating the head pressure.Type: ApplicationFiled: April 21, 2011Publication date: August 11, 2011Inventors: Douglas T. Gjerde, Ronald Jones, Allen Burge
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Patent number: 7943393Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the method involves adjusting the head pressure of the column during the process, or otherwise controlling or regulating the head pressure.Type: GrantFiled: July 20, 2004Date of Patent: May 17, 2011Assignee: PhyNexus, Inc.Inventors: Douglas T. Gjerde, Ronald Jones, Allen Burge
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Publication number: 20110038769Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the extraction columns are comprised of frits having a low pore. In some embodiments, the frits of the extraction columns have a pore volume of less than one microliter or less than 10% of the interstitial volume of the bed of extraction media.Type: ApplicationFiled: July 15, 2010Publication date: February 17, 2011Inventors: Douglas T. Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Patent number: 7875462Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the extraction columns are comprised of frits having a low pore. In some embodiments, the frits of the extraction columns have a pore volume of less than one microliter or less than 10% of the interstitial volume of the bed of extraction media.Type: GrantFiled: March 23, 2010Date of Patent: January 25, 2011Assignee: PhyNexus, Inc.Inventors: Douglas T. Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Publication number: 20100179308Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the extraction columns are comprised of frits having a low pore. In some embodiments, the frits of the extraction columns have a pore volume of less than one microliter or less than 10% of the interstitial volume of the bed of extraction media.Type: ApplicationFiled: March 23, 2010Publication date: July 15, 2010Inventors: Douglas T. Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Patent number: 7722820Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods characterized by the use of hydrophobic and/or hydrophilic membranes as frits, and/or by the inclusion of a wad of fibrous material to act as a wicking agent.Type: GrantFiled: November 21, 2005Date of Patent: May 25, 2010Assignee: PhyNexus, Inc.Inventors: Douglas T. Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Publication number: 20060198765Abstract: The invention provides a sample preparation device for processing a plurality of fluid samples comprising: (a) a plurality of sample processing chambers connected in parallel, each chamber having an internal surface and inlet and outlet ports; (b) media chambers disposed within each sample processing chamber, each media chamber comprising: (i) a bottom frit attached to and extending across the sample processing chamber; and (ii) a top barrier attached to and extending across the sample processing chamber between the bottom frit and the inlet port, wherein the top barrier, bottom frit and internal surface define a media chamber having a first average cross-sectional area; and (c) a bed of separation medium positioned inside the media chamber. In certain embodiments, the top barrier is a frit and/or the separation medium comprises gel resin beads.Type: ApplicationFiled: March 2, 2006Publication date: September 7, 2006Inventors: Douglas Gjerde, Christopher Hanna, Allen Burge
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Publication number: 20060124551Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods characterized by the use of hydrophobic and/or hydrophilic membranes as frits, and/or by the inclusion of a wad of fibrous material to act as a wicking agent.Type: ApplicationFiled: November 21, 2005Publication date: June 15, 2006Inventors: Douglas Gjerde, Allen Burge, Ronald Jones, Mark Abel
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Publication number: 20050255604Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies.Type: ApplicationFiled: August 17, 2004Publication date: November 17, 2005Inventors: Douglas Gjerde, Christopher Hanna, Allen Burge
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Publication number: 20050045543Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods of storing columns in a wet state.Type: ApplicationFiled: August 17, 2004Publication date: March 3, 2005Inventors: Douglas Gjerde, Ronald Jones, Allen Burge, Christopher Hanna, Leon Yengoyan
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Publication number: 20050019951Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods characterized by the use of verly slow flow rates.Type: ApplicationFiled: August 17, 2004Publication date: January 27, 2005Inventors: Douglas Gjerde, Allen Burge, Christopher Hanna
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Publication number: 20050019950Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the method involves adjusting the head pressure of the column during the process, or otherwise controlling or regulating the head pressure.Type: ApplicationFiled: July 20, 2004Publication date: January 27, 2005Inventors: Douglas Gierde, Ronald Jones, Allen Burge