Patents by Inventor Allen D. Everett

Allen D. Everett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-PROTEIN BIOMARKER ASSAY FOR BRAIN INJURY DETECTION AND OUTCOME
    Publication number: 20230077876
    Abstract: The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.
    Type: Application
    Filed: November 8, 2022
    Publication date: March 16, 2023
    Applicant: The Johns Hopkins University
    Inventors: Allen D. EVERETT, Jennifer E. VAN EYK, Frederick KORLEY
  • Multi-protein biomarker assay for brain injury detection and outcome
    Patent number: 11499982
    Abstract: The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: November 15, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Allen D. Everett, Jennifer E. Van Eyk, Frederick Korley
  • MULTI-PROTEIN BIOMARKER ASSAY FOR BRAIN INJURY DETECTION AND OUTCOME
    Publication number: 20200116739
    Abstract: The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 16, 2020
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: ALLEN D. EVERETT, JENNIFER E. VAN EYK, FREDERICK KORLEY
  • Circulating pulmonary hypertension biomarker
    Patent number: 10557860
    Abstract: Methods and kits for determining, predicting, or diagnosing pulmonary artery hypertension (PAH) and for determining the efficacy of PAH therapy using biomarkers are provided.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: February 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Allen D. Everett, Jun Yang
  • Multi-protein biomarker assay for brain injury detection and outcome
    Patent number: 10534003
    Abstract: The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: January 14, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Allen D. Everett, Jennifer E. Van Eyk, Frederick Korley
  • CIRCULATING PULMONARY HYPERTENSION BIOMARKER
    Publication number: 20170269106
    Abstract: Methods and kits for determining, predicting, or diagnosing pulmonary artery hypertension (PAH) and for determining the efficacy of PAH therapy using biomarkers are provided.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 21, 2017
    Applicant: The Johns Hopkins University
    Inventors: Allen D. Everett, Jun Yang
  • MULTI-PROTEIN BIOMARKER ASSAY FOR BRAIN INJURY DETECTION AND OUTCOME
    Publication number: 20160178643
    Abstract: The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.
    Type: Application
    Filed: July 17, 2014
    Publication date: June 23, 2016
    Inventors: Allen D. Everett, Jennifer E. Van Eyk, Frederick Korley