Patents by Inventor Allen E. Buhl

Allen E. Buhl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays and methods of diagnosis and treatment based on use of sodium channels as targets for amyloid beta or its aggregates
    Publication number: 20030211542
    Abstract: Among other things, assays and methods of diagnosis and treatment of disease (e.g., Alzheimer's disease) based on the surprising observation of an interaction between amyloid &bgr; or its aggregates with the sodium channel are provided. In particular, methods to identify compounds that modulate this interaction are provided, as well as methods of diagnosis and treatment that are based on this interaction.
    Type: Application
    Filed: May 14, 2003
    Publication date: November 13, 2003
    Inventors: Kai S. Lee, Xiao-Dong Sun, Bruce M. Taylor, Dennis E. Epps, Allen E. Buhl
  • Method for identifying compounds that modulate the interaction of amyloid beta or its aggregates with a voltage gated sodium channel
    Patent number: 6589747
    Abstract: Among other things, assays and methods of diagnosis and treatment of disease (e.g., Alzheimer's disease) based on the surprising observation of an interaction between amyloid &bgr; or its aggregates with the sodium channel are provided. In particular, methods to identify compounds that modulate this interaction are provided, as well as methods of diagnosis and treatment that are based on this interaction.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: July 8, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Kai S. Lee, Xiao-Dong Sun, Bruce M. Taylor, Dennis E. Epps, Allen E. Buhl
  • Assays and methods of diagnosis and treatment based on use of sodium channels as targets for amyloid beta or its aggregates
    Publication number: 20020004194
    Abstract: Among other things, assays and methods of diagnosis and treatment of disease (e.g., Alzheimer's disease) based on the surprising observation of an interaction between amyloid &bgr; or its aggregates with the sodium channel are provided. In particular, methods to identify compounds that modulate this interaction are provided, as well as methods of diagnosis and treatment that are based on this interaction.
    Type: Application
    Filed: December 21, 2000
    Publication date: January 10, 2002
    Inventors: Kai S. Lee, Xiao-Dong Sun, Bruce M. Taylor, Dennis E. Epps, Allen E. Buhl
  • Stimulation of hair growth with minoxidil and a 5.alpha.-reductase inhibitor
    Patent number: 5578599
    Abstract: An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium channel openers, such as minoxidil, cromakalim, pinacidil, or a compound selected frown the classes of s-triazine, thiane-1-oxide, benzopyran and pyridinopyran compounds; and a 5.alpha.-reductase inhibitors, 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one. The method comprises administering an effective amount of the potassium channel opener and administering an effective amount of the 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one whereby the promotion of hair growth is increase over the sole administration of the potassium channel opener.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: November 26, 1996
    Assignee: The Upjohn Company
    Inventors: Arthur R. Diani, Allen E. Buhl, Heinrich J. Schostarez
  • Treatment of erectile dysfunction
    Patent number: 5488059
    Abstract: A method to induce or enhance an erection or treat erectile dysfunction through the administration of a pyridylguanidine compound, preferably, N-cyano-N'(1,1-dimethyl propyl)-N"-3-pyridinyl guanidine, in low doses to the penis. Administration can be by injection into the corpus cavernosum of the penis or transdermal application.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: January 30, 1996
    Assignee: The Upjohn Company
    Inventor: Allen E. Buhl