Abstract: An endoscopic system may include an endoscope including a handle and an elongate shaft extending distally therefrom. The handle may include a non-motorized and non-ratcheting actuation mechanism configured to articulate a distal tip portion of the elongate shaft. The distal tip portion may be articulatable in response to a manually applied force exerted upon the actuation mechanism. Removal of the manually applied force may lock the distal tip portion in its then-current configuration. The non-motorized and non-ratcheting actuation mechanism may include a clutch mechanism actuatable in response to an electrical signal generated in response to sensing a user-applied force to the actuating mechanism by a strain gauge.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An endoscopic system may include an endoscope including a handle and an elongate shaft extending distally therefrom. The handle may include a non-motorized and non-ratcheting actuation mechanism configured to articulate a distal tip portion of the elongate shaft. The distal tip portion may be articulatable in response to a manually applied force exerted upon the actuation mechanism. Removal of the manually applied force may lock the distal tip portion in its then-current configuration. The non-motorized and non-ratcheting actuation mechanism may include a clutch mechanism actuatable in response to an electrical signal generated in response to sensing a user-applied force to the actuating mechanism by a strain gauge.

Abstract: An electronic device includes an electronic component configured to receive electric current and a plated contact electrically coupled to the electronic component and configured to carry the electric current to the electronic component from a system external to the device. The plated contact includes a copper-alloy layer, a platinum-group metal (PGM) layer plated over the copper-alloy layer, and a gold-alloy layer plated over the PGM layer.

Abstract: An electronic device includes an electronic component configured to receive electric current and a plated contact electrically coupled to the electronic component and configured to carry the electric current to the electronic component from a system external to the device. The plated contact includes a copper-alloy layer, a platinum-group metal (PGM) layer plated over the copper-alloy layer, and a gold-alloy layer plated over the PGM layer.

Abstract: Systems and methods provide a facility for automated gifting. The facility receives from a gifter an identification of a gift recipient, an indication of an occasion, and selection criteria. The facility automatically selects a proposed gift for the indicated occasion based on at least the received selection criteria and, in the absence of further direction from the gifter, sends the gift to the recipient.

Abstract: Systems and methods provide a facility for automated gifting. The facility receives from a gifter an identification of a gift recipient, an indication of an occasion, and selection criteria. The facility automatically selects a proposed gift for the indicated occasion based on at least the received selection criteria and, in the absence of further direction from the gifter, sends the gift to the recipient.

Abstract: Systems and methods provide a facility for automated gifting. The facility receives from a gifter an identification of a gift recipient, an indication of an occasion, and selection criteria. The facility automatically selects a proposed gift for the indicated occasion based on at least the received selection criteria and, in the absence of further direction from the gifter, sends the gift to the recipient.

Abstract: A metallurgically formed fluid circuit joint includes a hollow fitting (298), a tubular conduit (297), and a metallurgically formed tube/fitting mesh (296). The tube/fitting mesh (296) includes a fitting portion of the hollow fitting (298) and a tube portion of the tubular conduit (297) that is electromagnetically formed with the fitting portion.

Abstract: A method of forming titanium structures, and more specifically, a method of superplastically continuous roll forming titanium structures are disclosed herein. In one embodiment, a method of forming a shape in an article comprising titanium, the method including, among other things, providing first and second rolling members, the first rolling members being conductive and the second rolling members being continuous roll shaping members; contacting the article with the first rolling members to transfer a current to the article to heat the article to a temperature suitable for superplastic forming; and with the article being in a superplastic state, contacting the article with the second rolling members to form the shape in the article.

Abstract: A magnetic forming system (10) for creating a fluid circuit joint between a tube and a fitting includes an induction coil (12). The induction coil (12) may form a first stage electromagnetic current. A field concentrator (132) may focus the first stage electromagnetic current to form a second stage electromagnetic current. An insert (136) may focus the second stage electromagnetic current to form an electromagnetic field. The electromagnetic field forms the fluid circuit joint. The induction coil (12) may be insertable within the tube, generate an electromagnetic field, and impose the electromagnetic field on and to expand a portion of the tube within the fitting to form the fluid circuit joint. The system (10) may include a receptacle (54) that is external to the tube and the fitting. An insert (56) may be mechanically coupled within the receptacle (54) and limit the outward expansion of the tube and the fitting.

Abstract: A metallurgically formed fluid circuit joint includes a hollow fitting (298), a tubular conduit (297), and a metallurgically formed tube/fitting mesh (296). The tube/fitting mesh (296) includes a fitting portion of the hollow fitting (298) and a tube portion of the tubular conduit (297) that is electromagnetically formed with the fitting portion.

Abstract: The inventions relate to methods for trimming integrated circuits. Various embodiments include providing a method to trim an integrated circuit wherein trim data is stored in an on-board memory and then sent off of the circuit to be operated on by an external device. Corresponding trim data is then sent back to the integrated circuit in order to potentially modify the function of one or more analog devices along the circuit. Other embodiments include methods for trimming integrated circuits wherein trim data is stored in an on-board memory and retrieved using an on-board sequencer. The retrieved data is used to modify a function of one or more analog devices on the integrated circuit.

Abstract: A metallurgically formed fluid circuit joint includes a hollow fitting (298), a tubular conduit (297), and a metallurgically formed tube/fitting mesh (296). The tube/fitting mesh (296) includes a fitting portion of the hollow fitting (298) and a tube portion of the tubular conduit (297) that is electromagnetically formed with the fitting portion.

Abstract: An electromagnetically formed fluid circuit joint (276) includes a hollow fitting (272) and a tubular conduit (274). The hollow fitting (272) has an outer surface (280) with a groove (278). The tubular conduit (274) is received over the hollow fitting (272). The tubular conduit (274) includes a fitting overlay section (284), a first wall deformation for extension of the fitting overlay section (284) over the hollow fitting (272), and an electromagnetic field formed wall deformation (291) that extends into the groove (278). Another electromagnetically formed fluid circuit joint (642) includes a hollow fitting (654) and a tubular conduit (648). The hollow fitting (654) has an inner surface (668) with a groove (666). The tubular conduit (648) is mechanically separate from and is received within the hollow fitting (654). The tubular conduit (648) includes an externally applied electromagnetic field formed wall deformation (667) that extends into the groove (666).

Abstract: A magnetic forming system (10) for creating a fluid circuit joint between a tube and a fitting includes an induction coil (12). The induction coil (12) may form a first stage electromagnetic current. A field concentrator (132) may focus the first stage electromagnetic current to form a second stage electromagnetic current. An insert (136) may focus the second stage electromagnetic current to form an electromagnetic field. The electromagnetic field forms the fluid circuit joint. The induction coil (12) may be insertable within the tube, generate an electromagnetic field, and impose the electromagnetic field on and to expand a portion of the tube within the fitting to form the fluid circuit joint. The system (10) may include a receptacle (54) that is external to the tube and the fitting. An insert (56) may be mechanically coupled within the receptacle (54) and limit the outward expansion of the tube and the fitting.

Abstract: An apparatus for, and method of, replacing conventional antennas which transmit radio frequency energy from radio frequency transmitters. The invention provides for the use of any conductive surface as a transmitting antenna by taking advantage of the fact that any electrical conductor or surface that is 0.1 wavelengths or longer will radiate RF energy when injected with sufficient current. The RF current injecting antenna device, employing the principles of an instrument transformer, couples RF energy from a transmitter to a linear conductive element or a conductive surface. The useful frequency range that has been demonstrated for the device is 2 MHz to 1 GHz.

Abstract: This wheel gauge is for use in obtaining primary measurement data of an unidentified automobile wheel and includes a hub opening indicator, a bolt circle diameter indicator and a rim diameter indicator. The gauge includes a base plate and the hub opening indicator is provided by stepped elements mounted to the base plate and selectively insertable into the hub opening; the bolt circle indicator is provided by a sliding element mounted to the base plate and having a transverse plunger receivable into the bolt openings, and the rim indicator is provided by a movable element mounted to the base plate and movable into engagement with the wheel rim.A modified device includes a plurality of components each having a base including a reduced portion providing a hub opening indicator and an offset portion providing a bolt circle indicator said portions being insertable into the hub and bolt openings respectively.