Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A three-dimensional force and torque converter unit for measuring an external force or torque applied to the unit and converting it into a signal, whereby the signal may be used to control a system or device incorporating the converter unit. The converter unit includes a controller formed with four spaced apart arms having six or more degrees of constraint. A force or torque may be applied to the tip portions of each of the arms via a gripping means. Sensors are used to measure the deflection of the arms under an applied loading or torque and an output signal is generated.

Abstract: A software module for providing a user interface for a hardware peripheral device for controlling graphical elements of a virtual world defined in a computer system and rendered on a display device of the computer system, the module providing software including motion algorithms, and the module being capable of generating, with reference to the rendered graphical element, an icon (hereinafter called a motion handle) which represents a point in three dimensional space about which the graphical element may be manipulated, the point being used by the algorithms as the centre of rotation and zoom, and being used to define relative panning speeds whereby the algorithms cause changes to the rendered image of the graphical element responsive to rotation, zoom and pan input signals generated in the peripheral device.

Abstract: A transducer assembly has a generally planar resonator (12) (such as a disc) bonded on one face to a sheet of piezoelectric material (12B) and having a mounting flange (12C) (which may extend all around the periphery of the resonator) to mount the resonator between inner (13) and outer (11) mounting elements such as rings. An electric circuit (24) drives the piezoelectric sheet (12B) and, when used for sound generation, a tuned acoustic structure is provided for directing sound away from the resonator (12).

Abstract: In one embodiment, there is disclosed a surgical instrument for the dissection of bone or other tissue, the surgical instrument including a tool having a shaft with a dissection area disposed adjacent a distal end and a coupling area disposed adjacent a proximal end; a coupling assembly configured for coupling to a power output of a motor to said coupling area of said tool; and an angled attachment tube positionable along at least a portion of said shaft and substantially supporting a portion of said shaft disposed adjacent said dissection area.

Abstract: A surgical attachment instrument and method according to which a housing is adapted to be coupled to a motor. A tubular member is coupled to the housing so that an end of the tubular member extends from the housing at a predetermined distance. The predetermined distance may be selectively adjusted by a repeatable increment.