Patents by Inventor Allen I. Laskin
Allen I. Laskin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4375515Abstract: Disclosed are newly discovered and isolated methylotrophic microorganism strains and their natural and/or artificial mutants which grow well under aerobic conditions in a culture medium in the presence of methane as the major carbon and energy source. The methane-grown microbial cells possess a high content of protein and can be utilized as such as feedstuffs. The methane-grown microbial cells or enzyme preparations thereof are also useful in converting C.sub.1 -C.sub.6 alkanes to alcohols, particularly methane to methanol, C.sub.3 -C.sub.6 alkanes to the corresponding C.sub.3 -C.sub.6 sec. alcohols and methyl ketones, C.sub.3 -C.sub.6 sec. alcohols to the corresponding methyl ketones, cyclic hydrocarbons to cyclic hydrocarbyl alcohols (e.g., cyclohexane to cyclohexanol) C.sub.2 -C.sub.4 alkenes selected from the group consisting of ethylene, propylene, butene-1 and butadiene to 1,2-epoxides, styrene to styrene oxide, and converting other oxidizable substrates to oxidized products.Type: GrantFiled: December 11, 1980Date of Patent: March 1, 1983Assignee: Exxon Research and Engineering Co.Inventors: Ramesh N. Patel, Ching-Tsang Hou, Allen I. Laskin
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Patent number: 4368267Abstract: A process is disclosed for the epoxidation of lower .alpha.-olefins dienes or vinyl aromatic compounds by contacting said compounds, under aerobic conditions in the presence of microorganisms, genetically engineered organisms thereof or enzyme preparations derived from said microorganisms. The microorganisms, genetically engineered organisms, or enzyme preparations derived therefrom are preferably those microorganisms which are known as methylotrophs particularly those which have previously grown under aerobic conditions in a nutrient medium containing methane.Type: GrantFiled: February 6, 1980Date of Patent: January 11, 1983Assignee: Exxon Research and Engineering Co.Inventors: Ching-Tsang Hou, Ramesh N. Patel, Allen I. Laskin
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Patent number: 4347319Abstract: A process is disclosed for the microbiological epoxidation of C.sub.2 -C.sub.4 n-alkenes, dienes and vinyl aromatic compounds by contacting, under aerobic conditions, in an aqueous medium containing microorganisms or enzyme preparations derived therefrom, wherein the microorganisms have been aerobically cultivated in a nutrient medium containing methane. The microorganisms used are newly isolated methane-utilizing obligate and facultative methylotrophs.Type: GrantFiled: October 24, 1980Date of Patent: August 31, 1982Assignee: Exxon Research & Engineering Co.Inventors: Ching-Tsang Hou, Ramesh N. Patel, Allen I. Laskin
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Patent number: 4269940Abstract: Disclosed is a process for the microbiological oxidation of C.sub.1 -C.sub.6 alkanes and cycloalkanes by contacting said C.sub.1 -C.sub.6 alkanes or cycloalkanes, under aerobic conditions, in the presence of microorganisms or enzyme preparations derived therefrom, wherein said microorganisms have been aerobically grown in a nutrient containing methane. The microorganisms are newly isolated obligative and facultative methylotrophs.Type: GrantFiled: March 27, 1979Date of Patent: May 26, 1981Assignee: Exxon Research & Engineering Co.Inventors: Ramesh N. Patel, Ching-Tsang Hou, Allen I. Laskin
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Patent number: 4268630Abstract: A process is disclosed for the microbiological production of ketones from C.sub.3 -C.sub.6 alkanes by contacting C.sub.3 -C.sub.6 alkanes under aerobic conditions with resting microbial cells derived from a methylotrophic microorganism or enzyme preparation derived from said cells, wherein the microorganism has been previously grown under aerobic conditions in a nutrient medium containing methane or dimethyl ether.Type: GrantFiled: March 30, 1979Date of Patent: May 19, 1981Assignee: Exxon Research & Engineering Co.Inventors: Ramesh N. Patel, Ching-Tsang Hou, Allen I. Laskin
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Patent number: 4266034Abstract: Disclosed are newly discovered and isolated methylotrophic microorganism strains and their natural and/or artificial mutants which grow well under aerobic conditions in a culture medium in the presence of methane as the major carbon and energy source. The methane-grown microbial cells possess a high content of protein and can be utilized as such as feedstuffs. The methane-grown microbial cells or enzyme preparations thereof are also useful in converting C.sub.1 -C.sub.6 alkanes to alcohols, particularly methane to methanol, C.sub.3 -C.sub.6 alkanes to the corresponding C.sub.3 -C.sub.6 sec. alcohols and methyl ketones, C.sub.3 -C.sub.6 sec. alcohols to the corresponding methyl ketones, cyclic hydrocarbons to cyclic hydrocarbyl alcohols (e.g., cyclohexane to cyclohexanol) C.sub.2 -C.sub.4 alkenes selected from the group consisting of ethylene, propylene, butene-1 and butadiene to 1,2-epoxides, styrene to styrene oxide, and converting other oxidizable substrates to oxidized products.Type: GrantFiled: March 27, 1979Date of Patent: May 5, 1981Assignee: Exxon Research and Engineering CompanyInventors: Ramesh N. Patel, Ching-Tsang Hou, Allen I. Laskin
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Patent number: 4256590Abstract: A composition containing a heteropolysaccharide produced by the action of bacteria of the genus Xanthomonas, wherein the heteropolysaccharide has been modified by heating, at a temperature of at least 100.degree. C. for 1 to about 300 minutes, an aqueous solution containing native, untreated heteropolysaccharide produced by the action of bacteria of the genus Xanthomonas, and at least about 0.5 weight percent salt. The solution is preferably filtered or otherwise treated to separate the modified heteropolysaccharide from bacterial cells, cellular debris and other materials, prior to being put to use in, e.g., oil recovery processes, additive for foodstuffs, pharmaceutical preparations, etc.Type: GrantFiled: April 11, 1979Date of Patent: March 17, 1981Assignee: Exxon Research & Engineering Co.Inventors: Lars A. Naslund, Allen I. Laskin
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Patent number: 4250259Abstract: A process is disclosed for the microbiological production of ketones from C.sub.3 -C.sub.6 secondary alcohols by contacting C.sub.3 -C.sub.6 secondary alcohols under aerobic conditions with resting microbial cells derived from a microorganism of enzyme preparation derived from said cells, wherein the microorganism has been previously grown under aerobic conditions in a nutrient medium containing a methyl-radical donating compound. Typical methyl-radical donating compounds are: methane, methanol, dimethyl ether, methylamine, methyl formate, methyl carbonate, ethanol, propanol, butanol, etc. Isolation and purification of a novel C.sub.3 -C.sub.6 secondary alcohol dehydrogenase enzyme is also disclosed.Type: GrantFiled: March 30, 1979Date of Patent: February 10, 1981Assignee: Exxon Research & Engineering Co.Inventors: Ching-Tsang Hou, Ramesh N. Patel, Allen I. Laskin
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Patent number: 4241184Abstract: Disclosed is a newly-discovered and isolated enzyme which is a nicotinamide adenine dinucleotide (NAD.sup.+)-linked C.sub.3 -C.sub.6 secondary alcohol-specific dehydrogenase. This enzyme, in the presence of oxygen and NAD, is capable of converting C.sub.3 -C.sub.6 secondary alcohols to the corresponding methyl ketones. The purified enzyme has a molecular weight of 95,000 .+-. 3,000 dalton as determined by acrylamide gel electrophoresis and contains two zinc atoms per molecule of protein. Primary alcohols are not oxidized by this enzyme.Type: GrantFiled: March 27, 1979Date of Patent: December 23, 1980Assignee: Exxon Research & Engineering Co.Inventors: Ching-Tsang Hou, Ramesh N. Patel, Allen I. Laskin
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Patent number: 4182860Abstract: A process for producing modified heteropolysaccharides derived from a bacteria of the genus Xanthomonas, comprising the steps: (a) preparing an aqueous solution which contains (i) from about 200 to about 30,000 parts per million, by weight of an impure and unmodified heteropolysaccharide product and (ii) at least about 0.5 weight percent of at least one salt to obtain a saline heteropolysaccharide solution; (b) heating said saline heteropolysaccharide solution to a temperature of at least about 100.degree. C.; (c) maintaining said saline heteropolysaccharide solution at a temperature of at least about 100.degree. C.Type: GrantFiled: May 9, 1977Date of Patent: January 8, 1980Inventors: Lars A. Naslund, Allen I. Laskin
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Patent number: 4146470Abstract: A method of preparation and application of a composition comprising specified microorganisms in combination with surfactants for a synergistic dispersal of oil slicks.Type: GrantFiled: July 22, 1977Date of Patent: March 27, 1979Assignee: Exxon Research & Engineering Co.Inventors: Raam R. Mohan, Max L. Robbins, Allen I. Laskin, Lars A. Naslund
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Patent number: 3970521Abstract: Glycoenzymes are immobilized by oxidizing a carbohydrate portion of the enzyme to a carbonyl group or a precursor thereof and reacting the resultant carbonyl group on the enzyme with an amino group of an amino-containing water insoluble polymer to produce a water insoluble conjugate. This method avoids loss of enzyme activity as a result of the carbohydrate portion of the enzyme which is catalytically inert being utilized in preparing the water-insoluble conjugate.Type: GrantFiled: August 7, 1974Date of Patent: July 20, 1976Assignee: Exxon Research and Engineering CompanyInventors: Oskar R. Zaborsky, Allen I. Laskin