Patents by Inventor Allen J. Ebens

Allen J. Ebens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
    Publication number: 20080248053
    Abstract: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
    Type: Application
    Filed: August 3, 2007
    Publication date: October 9, 2008
    Applicant: Seattle Genetics, Inc.
    Inventors: Svetlana O. Doronina, Peter D. Senter, Brian E. Toki, Allen J. Ebens, Toni Beth Kline, Paul Polakis, Mark X. Sliwkowski, Susan D. Spencer
  • MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
    Publication number: 20080226657
    Abstract: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
    Type: Application
    Filed: August 3, 2007
    Publication date: September 18, 2008
    Applicant: Seattle Genetics, Inc.
    Inventors: Svetlana O. Doronina, Peter D. Senter, Brian E. Toki, Allen J. Ebens, Toni Beth Kline, Paul Polakis, Mark X. Sliwkowski, Susan D. Spencer
  • ANTIBODY-DRUG CONJUGATES AND METHODS
    Publication number: 20080171040
    Abstract: The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)pI where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
    Type: Application
    Filed: March 21, 2008
    Publication date: July 17, 2008
    Applicant: Genentech, Inc.
    Inventors: Allen J. Ebens,, Frederic S. Jacobson, Paul Polakis, Ralph H. Schwall, Mark X. Sliwkowski, Susan D. Spencer
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR OF HEMATOPOIETIC ORIGIN
    Publication number: 20080166294
    Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: August 1, 2006
    Publication date: July 10, 2008
    Applicant: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Dan L. Eaton, Allen J. Ebens, Andrew Polson, Victoria Smith, Suzie J. Scales, Gladys Ingle
  • Polynucleotides encoding insect ethanolamine kinase and uses thereof
    Patent number: 6913899
    Abstract: The instant invention provides nucleic acid molecules encoding insect ethanolamine kinase, as well as ethanolamine kinase encoded thereby. The invention further provides methods of identifying agents that modulate a level of ethanolamine kinase mRNA, polypeptide, or enzyme activity. Such agents are candidate insecticidal compounds.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: July 5, 2005
    Assignee: Genoptera, LLC
    Inventors: Allen J. Ebens, Jr., Stuart Johnston, Jean-Claude Breach
  • Polynucleotides encoding insect cysteine protease and uses thereof
    Publication number: 20030049711
    Abstract: The instant invention provides nucleic acid molecules encoding insect 26/29 cysteine protease, as well as 26/29 cysteine protease encoded thereby. The invention further provides methods of identifying agents that modulate a level of 26/29 cysteine protease mRNA, polypeptide, or enzyme activity. Such agents are candidate insecticidal compounds.
    Type: Application
    Filed: June 26, 2002
    Publication date: March 13, 2003
    Inventors: Allen J. Ebens, Thomas J. Stout, Stuart Johnston, Dat Nguyen
  • Polynucleotides encoding insect ethanolamine kinase and uses thereof
    Publication number: 20030027191
    Abstract: The instant invention provides nucleic acid molecules encoding insect ethanolamine kinase, as well as ethanolamine kinase encoded thereby. The invention further provides methods of identifying agents that modulate a level of ethanolamine kinase mRNA, polypeptide, or enzyme activity. Such agents are candidate insecticidal compounds.
    Type: Application
    Filed: July 11, 2002
    Publication date: February 6, 2003
    Inventors: Allen J. Ebens, Stuart Johnston, Jean-Claude Breach
  • Polynucleotides encoding insect glutaminyl cyclase and uses thereof
    Publication number: 20030013177
    Abstract: The invention provides polynucleotides encoding insect glutaminyl cyclase, as well as polypeptides encoded thereby. The invention further provides host cells comprising expression vectors comprising polynucleotides of the invention. Isolated polypeptides and host cells of the invention are useful in methods of screening for agents that reduce glutaminyl cyclase activity. Such agents are useful as pesticides.
    Type: Application
    Filed: May 21, 2002
    Publication date: January 16, 2003
    Inventors: Allen J. Ebens, Jean-Claude R. Breach, Stuart Johnston, Julie B. Mazzotta