Patents by Inventor Allen J. Fasbender

Allen J. Fasbender has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complexes of adenovirus with cationic molecules
    Patent number: 5962429
    Abstract: The present invention provides noncovalent complexes of cationic molecules and adenoviral vectors containing a transgene. The complexes of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the complexes are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to a CF patient utilizing a complex of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: October 5, 1999
    Assignee: University of Iowa
    Inventors: Michael J. Welsh, Allen J. Fasbender
  • Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
    Patent number: 5935936
    Abstract: Novel compositions are provided. Typically, the compositions comprise one or more neutral co-lipids and also a cationic amphiphile. Therapeutic compositions are prepared according to the practice of the invention by contacting a therapeutically active molecule with a dispersion of neutral co-lipid(s) and amphiphile(s).
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: August 10, 1999
    Assignees: Genzyme Corporation, University of Iowa
    Inventors: Allen J. Fasbender, Michael J. Welsh, Craig S. Siegel, Edward R. Lee, Chau-Dung Chang, John Marshall, Seng H. Cheng, David J. Harris, Simon J. Eastman, Shirley C. Hubbard, Mathieu B. Lane, Eric A. Rowe, Ronald K. Scheule, Nelson S. Yew