Patents by Inventor Allen M. Spiegel

Allen M. Spiegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • , the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof
    Patent number: 7358347
    Abstract: The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: April 15, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Settara Chandrasekharappa, Siradanahalli Guru, Pachiappan Manickam, Francis S. Collins, Michael R. Emmert-Buck, Larisa V. Debelenko, Irina A. Lubensky, Lance A. Liotta, Sunita K. Agarwal, Allen M. Spiegel, A. Lee Burns, Stephen J. Marx, Zhengping Zhuang
  • Antibody reagents that identify the carboxy-terminal peptide of the GTP-binding protein G.sub.o
    Patent number: 5436320
    Abstract: Antibodies having binding specificity for a peptide having the sequence ANNLRGCGLY have been prepared. The antibodies bind to the GTP-binding protein G.sub.o and are useful for identifying, isolating and distinguishing between different GTP binding proteins.
    Type: Grant
    Filed: January 14, 1992
    Date of Patent: July 25, 1995
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventor: Allen M. Spiegel
  • Antibody reagents that specifically bind to the carboxyl-terminal decaptide of specific GTP-binding proteins
    Patent number: 5428134
    Abstract: Antibodies which bind to a peptide having the sequence KENLKDCGLF, which represents the C-terminal decapeptide of the GTP-binding protein transducin-.alpha., are described. Binding to transducin-.alpha. by peptide-specific antiserum AS/7 is not affected by pertussis toxin-catalyzed ADP-ribosylation.
    Type: Grant
    Filed: January 14, 1992
    Date of Patent: June 27, 1995
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventor: Allen M. Spiegel
  • Reagents and probes for distinguishing and isolating different GTP-binding proteins
    Patent number: 4870161
    Abstract: Substantially pure, synthetic peptides corresponding to specific epitopic sites of various G-proteins and antibodies having binding affinity specifically for said epitopic sites have been prepared. Kit and method for identifying various G-proteins are also disclosed.
    Type: Grant
    Filed: September 25, 1987
    Date of Patent: September 26, 1989
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Allen M. Spiegel