Abstract: A sleeve for placing on a human penis, the sleeve having a flexible sleeve wall having a proximal end and a distal end, the sleeve wall being configured and sized to extend from the just below the corona of the glans of the penis and along the body of the penis towards the base of the penis. The distal end includes a flange that extends radially outwards from an outer surface of the sleeve wall, the flange having an exterior side surface with a curved shape configured to match the shape of the corona of the glans of the penis.

Abstract: In accordance with some embodiments, a portable electronic device includes: a display; one or more processors; memory; and one or more programs, wherein the one or more programs are stored in the memory and configured to be executed by the one or mor processors. The one or more programs include instructions for: detecting a user-defined gesture on the display while the portable electronic device is in a user-defined-gesture recording mode; creating a representation of the user-defined gesture; associating the representation of the user-defined gesture with an emoji character; and storing the representation of the user-defined gesture and the association of the representation of the user-defined gesture with the emoji character.

Abstract: Provided herein are methods for making, and epitope-targeted, conditionally-activated, pro-drug, antibody, comprising: complementarity determining regions (CDRs) from an antibody identified from an in vivo, in vitro, or in silico antibody library; one or more engineered epitope masks connected to a linker, wherein the linker comprises a peptide, a polymer, or a chemical-linker that is cleaveable in vivo at a target site by an enzyme or cleaved chemically, and wherein the one or more engineered epitope masks binds the epitope-specific antibody at the CDRs of the epitope-specific antibody; and wherein the one or more engineered epitope masks linked to the antibody via the linker, wherein the masks are conditionally bound to the CDRs of the epitope-specific antibody, and wherein cleavage of the linker releases the one or more engineered epitope masks from the antigen binding site.

Abstract: A first light source with a first etendue generates a first light beam to travel along a first optical path having an expanded portion formed by a collector optical system. A second light source having a second etendue less than one tenth of the first etendue forms second light, which is conducted by a light guide having a distal section with an end face. The second light is emitted from the end face as a second light beam that travels over a second optical path that resides within the expanded portion of the first optical path due to the light guide being disposed relative to the first optical path from an off-axis direction. An optical condenser receives and directs the first and second light beams to a common exit plane to form the combined light beam.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Provided herein are compositions comprising niacin, berberine, one or more of silymarin, silibinin, and Siliphos®, lipoic acid, taurine, and phosphatidylcholine. Such compositions are useful for treating or preventing obesity, metabolic and hepatic and neurodegenerative disorders.

Abstract: In some examples, a system derives a first representation of an assembly of components based on a first source of information, and derives a second representation of the assembly of components based on a second source of information that is of a different type than the first source of information, where the second representation includes any or a combination of an indication of a source of a respective component of the assembly of components, or placement location information of a component in the assembly. The system compares the first representation to the second representation to identify a deviation between the first representation and the second representation, the deviation corresponding to an alteration of the assembly of components.

Abstract: Provided herein are imaging devices and methods of use thereof, the imaging devices comprising at least one illumination port configured to output light for illuminating a target; an imaging sensor assembly configured to detect light traveling to the imaging sensor assembly; and at least one drape sensor configured to detect a drape mounted to the device.

Abstract: Closed cavity adjustable sensor mount systems and methods are disclosed. The sensor mount systems include a sealed, closed cavity enclosing a sensor and forming a closed cavity sensor assembly. The closed cavity sensor assembly may be tilted and/or translated relative to a platform in order to adjust the orientation of the sensor to align it with an imaging optical axis. Following alignment, the closed cavity sensor assembly may be permanently or reversibly fixed in place. The closed cavity adjustable sensor mount systems may be part of medical imaging systems such as endoscopic imaging systems and/or open field imaging systems.

Abstract: A medical device for placing on a human penis, e.g., post penile enhancement procedure, includes a flexible sleeve having a proximal end and a distal end, the proximal end being sized and dimensioned to be positioned over the base of the penis, the sleeve being configured and sized to extend from the base of the penis and along the body of the penis, the distal end being sized and dimensioned to terminate just below the corona of the glans of the penis. The distal end may include a flange that extends radially outwards from an outer surface of the sleeve, and a thickness of the sleeve spaced away from the flange along a longitudinal axis of the sleeve may be about 4 mm-5 mm.

Abstract: Provided herein are novel human anti-CD3 antigen-binding polypeptides, treatments, nucleic acids, vectors, their preparation and their use in the treatment and/or diagnosis of various diseases, and also relates to bispecific antibody molecules capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases.

Abstract: Disclosed are new configurations of a rubidium elution system that offer several advantages. The rubidium elution systems of the present disclosure comprise an assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump, a sensor, a tubing circuit and at least one valve. The waste container is located in the lower section of the assembly. More particularly, the top surface of the waste container compartment is either below the top surface of the generator compartment, or the waste container is at the same elevation than the generator or below the pump.

Abstract: An imaging device may include a first illumination port to output first light having a first illumination distribution at a target to illuminate the target, a second illumination port to output second light having a second illumination distribution at the target to illuminate the target, the second illumination distribution being substantially similar to the first illumination distribution at the target, the second illumination port being spaced apart from the first illumination port, the first and second illumination distributions being simultaneously provided to the target and overlapping at the target. The illumination from the first and second ports may be matched to a same aspect ratio and field of view coverage as the imaging field of view.

Abstract: An electronic device displays one or more views of a software application with a plurality of gesture recognizers including at least one discrete gesture recognizer, configured to send a single action message in response to a respective gesture; and at least one continuous gesture recognizer, configured to send action messages at successive recognized sub-events of a respective recognized gesture. The device detects one or more events and processes each event using one or more of the gesture recognizers, including: processing the respective event at a respective gesture recognizer in accordance with a respective gesture definition corresponding to the respective gesture recognizer, and conditionally sending one or more respective action messages to the software application in accordance with an outcome of the processing of the respective event. The device executes the software application in accordance with one or more action messages received from one or more of the gesture recognizers.

Abstract: Provided herein are anti-MUC16 antibodies or binding fragments thereof which bind the non-shed domain of MUC16. The anti-MUC16 antibodies or binding fragments thereof of the disclosure are useful for the treatment of cancer cells that shed the extracellular domain of MUC16.

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: An imaging device having an imaging field of view, the imaging device including at least one illumination port configured to output light for illuminating a target; an imaging sensor to detect light traveling along an optical path to the imaging sensor; and a first movable window positioned upstream of the sensor with respect to a direction of travel of light along the optical path, wherein the first movable window is configured to move into the optical path in a deployed position for modifying light received from the target.

Abstract: Methods and systems of distinguishing between fluorescence imaging data contributions corresponding to two fluorescence imaging agents in a tissue is described herein. Specifically, exploitation of an imaging sensor with a color filter array can help distinguish between overlapping simultaneous fluorophore emission profiles.

Abstract: An optical system includes a first relay rod of a first material, a second relay rod of a second material, different from the first material, and a lens between the first and second relay rods.

Abstract: Disclosed herein are rubidium elution systems comprising a primary assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump system, a sensor, a tubing circuit, at least one valve, and a computer; and a dose calibrator outside the primary assembly. The system may have an interface for configuring the dose calibrator, and a locking means for preventing access to the interface and reconfigurations of its parameters. Moreover, the dose calibrator may be in electronic communication with the computer of the system. Furthermore, the electronic communication can be embodied with an electronic cable having a breakaway connector. Also, the dose calibrator may be positioned on a mobile platform.