Patents by Inventor Allen R. Comer

Allen R. Comer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of human skin substitutes expressing exogenous IL-12 to treat a wound bed
    Patent number: 11911444
    Abstract: The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: February 27, 2024
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann
  • ENGINEERED SKIN CONSTRUCT OVERLAY OF AUTOGRAFT
    Publication number: 20230330153
    Abstract: The present disclosure provides methods for treating wounds by applying a meshed autograft and skin substitute overlay wherein the skin substitute is an organotypic human skin equivalent comprising NIKS® cells.
    Type: Application
    Filed: July 8, 2021
    Publication date: October 19, 2023
    Inventors: ALLEN R. COMER, JANICE SMIELL, B. LYNN ALLEN-HOFFMANN, MARY LOKUTA, RANDI RUTAN
  • CRYOPRESERVATION OF VIABLE HUMAN SKIN SUBSTITUTES
    Publication number: 20220192181
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Cryopreservation of viable human skin substitutes
    Patent number: 11297829
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: April 12, 2022
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • VIABLE BIOENGINEERED SKIN CONSTRUCTS
    Publication number: 20210355451
    Abstract: The present disclosure is directed to viable bioengineered skin constructs.
    Type: Application
    Filed: May 13, 2021
    Publication date: November 18, 2021
    Inventors: B. Lynn Allen-Hoffmann, Allen R. Comer, Kenneth R. Gratz, Barry M. Steiglitz
  • HUMAN SKIN SUBSTITUTES EXPRESSING IL-12
    Publication number: 20190030130
    Abstract: The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann
  • CRYOPRESERVATION OF VIABLE HUMAN SKIN SUBSTITUTES
    Publication number: 20190000071
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Application
    Filed: September 5, 2018
    Publication date: January 3, 2019
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Cryopreservation of viable human skin substitutes
    Patent number: 10091983
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 9, 2018
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Dried and irradiated skin equivalents for ready use
    Patent number: 9867904
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: January 16, 2018
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE
    Publication number: 20170087276
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • Dried and irradiated skin equivalents for ready use
    Patent number: 9526811
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: December 27, 2016
    Assignee: STRATATECH CORPORATION
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE
    Publication number: 20150196686
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: March 26, 2015
    Publication date: July 16, 2015
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • Dried and irradiated skin equivalents for ready use
    Patent number: 8992997
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: March 31, 2015
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE
    Publication number: 20140288165
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: March 20, 2014
    Publication date: September 25, 2014
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • CRYOPRESERVATION OF VIABLE HUMAN SKIN SUBSTITUTES
    Publication number: 20140271583
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Method of treatment using organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1?
    Patent number: 8808685
    Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1?, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: August 19, 2014
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann
  • Dried and irradiated skin equivalents for ready use
    Patent number: 8685463
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 1, 2014
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE
    Publication number: 20140067064
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: October 15, 2013
    Publication date: March 6, 2014
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • Dried and irradiated skin equivalents for ready use
    Patent number: 8580314
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: November 12, 2013
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • METHOD OF TREATMENT USING ORGANOTYPICALLY CULTURED SKIN TISSUE COMPRISING NIKS CELLS THAT EXPRESS EXOGENOUS HIF-1A
    Publication number: 20110286985
    Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1?, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
    Type: Application
    Filed: August 1, 2011
    Publication date: November 24, 2011
    Applicant: STRATATECH CORPORATION
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann