Patents by Inventor Allen R. Kraska

Allen R. Kraska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition containing amlodipine or a pharmaceutically acceptable salt thereof, and an ACE inhibitor
    Patent number: 6245787
    Abstract: Methods of treating congestive heart failure in a mammal, especially a human, by co-administration of (1) amlodipine, a pharmaceutically acceptable salt of amlodipine; (2) an ACE inhibitor; and optionally (3) a diuretic and/or (4) digoxin.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: June 12, 2001
    Assignee: Pfizer Inc.
    Inventors: Anne B. Cropp, Allen R. Kraska
  • Method for inhibiting the degradation of cartilage
    Patent number: 4808597
    Abstract: Certain carboxylic acids of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject afflicted with an arthritic disease. X is O, S, SO, SO.sub.2, NH, NCH.sub.3 or NCOCH.sub.3 ; and n is zero or one.
    Type: Grant
    Filed: June 2, 1988
    Date of Patent: February 28, 1989
    Assignee: Pfizer Inc.
    Inventors: William W. Hoffman, Allen R. Kraska
  • Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4556676
    Abstract: Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4536518
    Abstract: Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenam ine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: November 1, 1979
    Date of Patent: August 20, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • Substituted piperazines having immune regulant activity
    Patent number: 4357332
    Abstract: 1-Benzyl- and 1-phenyl-4-(2-hydroxy-3-benzyloxypropyl)-piperazines useful as immune regulants are disclosed. Also disclosed are pharmaceutical compositions containing the novel compounds and a method of regulating immune response of a warm blooded animal by administration of the novel compounds.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: November 2, 1982
    Assignee: Pfizer Inc.
    Inventors: Allen R. Kraska, Joseph G. Lombardino
  • 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted piperidines, pharmaceutical compositions, thereof and use thereof
    Patent number: 4312877
    Abstract: 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines and derivatives thereof useful as immune regulants are disclosed. Also disclosed are pharmaceutical compositions containing the novel compounds and a method of regulating the immune response of a subject by administration of the novel compounds.
    Type: Grant
    Filed: October 31, 1980
    Date of Patent: January 26, 1982
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Compounds derived from formylphenoxyacetic acid as antiviral agents in animals
    Patent number: 4291060
    Abstract: Novel compounds derived from formylphenoxyacetic acid such as N,N-dihexadecyl-4-(aminomethyl)phenoxy acetamide and N,N-dihexacecyl-2-(4-(aminomethyl)phenoxy) ethylamine and their non-toxic acid addition salts are useful for combating viral infections in vertebrate animals.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: September 22, 1981
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Antiviral amine and amidine derivatives of glycerol and propanediols
    Patent number: 4262021
    Abstract: Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: April 14, 1981
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
    Patent number: 4255426
    Abstract: 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines and derivatives thereof useful as immune regulants are disclosed. Also disclosed are pharmaceutical compositions containing the novel compounds and a method of regulating the immune response of a subject by administration of the novel compounds.
    Type: Grant
    Filed: July 9, 1979
    Date of Patent: March 10, 1981
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Antiviral amine derivatives of glycerol and propanediols
    Patent number: 4215146
    Abstract: Novel amine and amidine derivatives of di-0-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-0-(n-hexadecyl)-2-0-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: February 15, 1979
    Date of Patent: July 29, 1980
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • N,N-Disubstituted aminomethylphenylethanolamines
    Patent number: 4211794
    Abstract: The novel N,N-bis(higher-n-alkyl)aminomethylphenylethanolamines and their mineral acid and organic acid salts are useful for preventing viral infections in mammals and also for stimulating cellular mediated immune response.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: July 8, 1980
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Antiviral amine derivatives of propanediols
    Patent number: 4193999
    Abstract: Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: February 15, 1979
    Date of Patent: March 18, 1980
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Di-O-n-alkyl glycerol derivatives as immune stimulants
    Patent number: 4173641
    Abstract: Novel 1,2- and 1,3-(di-O-n-alkyl)glycerol derivatives and their pharmaceutically acceptable acid addition salts are useful as non-specific stimulants of cell-mediated immunity.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: November 6, 1979
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Antiviral amine derivatives of glycerol and propanediols
    Patent number: 4166132
    Abstract: Novel amine and amidine derivatives of di-0-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-0-(n-hexadecyl)-2-0-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: August 18, 1977
    Date of Patent: August 28, 1979
    Assignee: Pfizer Inc.
    Inventor: Allen R. Kraska
  • Aromatic amidines as antiviral agents in animals
    Patent number: 4097525
    Abstract: Novel ?N,N-di(higher alkyl)aminomethyl!benzamidine and substituted compounds such as ?N,N-di(higher alkyl)aminomethyl!-N-(2-propyl)-benzamidine and ?N,N-di(higher alkyl)aminomethyl!-N-(p-hydroxyphenyl)-benzamidine and their non-toxic acid addition salts are useful for combating viral infections in vertebrate animals.
    Type: Grant
    Filed: October 13, 1977
    Date of Patent: June 27, 1978
    Assignee: Pfizer Inc.
    Inventors: Allen R. Kraska, Rodney C. Schnur
  • Aromatic amidines as antiviral agents in animals
    Patent number: 4066696
    Abstract: Novel [N,N-di(higher alkyl)aminomethyl]benzamidine and substituted compounds such as [N,N-di(higher alkyl)aminomethyl]-N-(2-propyl)-benzamidine and [N,N-di(higher alkyl)aminomethyl]-N-(p-hydroxyphenyphenyl)-benzamidine and their non-toxic acid addition salts are useful for combating viral infections in vertebrate animals.
    Type: Grant
    Filed: February 18, 1977
    Date of Patent: January 3, 1978
    Assignee: Pfizer Inc.
    Inventors: Allen R. Kraska, Rodney C. Schnur
  • Aromatic amidines as antiviral agents in animals
    Patent number: 4025555
    Abstract: Novel [N,N-di(higher alkyl)aminomethyl]benzamidine and substituted compounds such as [N,N-di(higher alkyl)aminomethyl]-N-(2-propyl)-benzamidine and [N,N-di(higher alkyl)aminomethyl]-N-(p-hydroxyphenyl)-benzamidine and their non-toxic acid addition salts are useful for combating viral infections in vertebrate animals.
    Type: Grant
    Filed: July 23, 1976
    Date of Patent: May 24, 1977
    Assignee: Pfizer Inc.
    Inventors: Allen R. Kraska, Rodney C. Schnur