Abstract: The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.

Abstract: This disclosure presents a pumping system that includes a plunger disposed in a pressure cylinder that is operable to be displaced in a suction and a discharge stroke. A packing seal is disposed between the plunger and the pressure cylinder. A valve lock is disposed separate from the pressure cylinder and houses a suction valve and a discharge valve. A conduit fluidly couples the pressure cylinder with the valve block.

Abstract: A linear frac pump includes a fluid end having an inlet valve disposed proximate to an inlet port, and a discharge valve disposed proximate to a discharge port. The pump further includes a first plunger rod housed within a first plunger housing, the first plunger rod having first and second ends, the first end being in fluid communication with the fluid end, and the second end being coupled to a first actuator. The pump includes a second plunger rod housed within a plunger housing, the second plunger rod having first and second ends, the first end being in fluid communication with the fluid end, and the second end being coupled to a second actuator. The first and second plunger rods and housings are coupled to the fluid end and the first and second plunger rods operate in sync to drive fluids inward from the inlet port and outward via the discharge port being regulated by the inlet and discharge valves.

Abstract: A linear pump includes a centrally-disposed drive system and a plunger having a center portion coupled to the drive system, and first and second fluid ends disposed at the first and second ends of the plunger. The pump further includes first and second packing seals each being disposed about the plunger to isolate fluids within the respective first and second fluid ends. First and second adapters are disposed at an interface between the drive system and respective first and second fluid ends, each adapter incorporating an angled deflector configured to deflect and redirect high-pressure fluids escaping past the respective packing seal toward the drive system.

Abstract: A reciprocating pump for a hydraulic fracking operation includes a plunger mechanically connected to a crankshaft for pumping a fluid through a cylinder, the cylinder having fluid ports for ingress and egress of fluid. An ingress valve is disposed at the ingress port, and a first actuator is coupled to the ingress valve and configured to actuate the ingress valve to be displaced between an enlarged open position to permit fluid flow through the ingress port and a closed position to prohibit fluid flow through the ingress port. An egress valve is disposed at the egress port, and a second actuator is coupled to the egress valve configured to actuate the egress valve to be displaced between an enlarged open position to permit fluid flow through the egress port and a closed position to prohibit fluid flow through the egress port.

Abstract: An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.

Abstract: A quick-connector assembly for joining abutting flanged ends of two tubular members includes first and second connector portions joined by a rotatable hinge having a hinge pin coupling the first connector portion and the second connector portion so that the first and second connector portions encircle about abutting flanged ends of the tubular members when the first and second connector portions are in a closed position. Further, a stand having a bracket with at least one hole for accommodating the hinge pin is designed to at least partially support the weight of the connector assembly and the flanged ends of the tubular members.

Abstract: An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.

Abstract: An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.

Abstract: A compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and one or more monovalent cations such as Na+ useful for the treatment of hypertension and/or heart failure.

Abstract: An amorphous solid form of a compound comprising the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This compound is useful for the treatment of hypertension and/or heart failure.

Abstract: A valve seat for use in a fluid end of a fracturing pump that includes a first body portion having an inner wall and an outer wall, wherein the inner wall forms a fluid bore and outer wall is configured to contact an inside surface of a fluid passageway of a fluid end of the fracturing pump for support therein. The seat further includes a second body portion extending from the first body portion, the second body having a frustro-conical portion forming a seating surface for receiving a valve. A portion of the first and second body portion includes a hardened material insert forming a portion of the seating surface and a portion of the inner wall of the first body, and further includes a metallic body portion affixed to the hardened material insert, the metallic body portion forming at least a portion of first body portion outer wall.

Abstract: A compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and one or more monovalent cations such as Na+ useful for the treatment of hypertension and/or heart failure.

Abstract: A compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and one or more monovalent cations such as Na+ useful for the treatment of hypertension and/or heart failure.

Abstract: A compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and one or more monovalent cations such as Na+ useful for the treatment of hypertension and/or heart failure.

Abstract: A compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and one or more monovalent cations such as Na+ useful for the treatment of hypertension and/or heart failure.

Abstract: An improved nitrification inhibitor composition comprising UFP particles and a nitrification inhibitor, and optionally other components, is used as an additive for liquid and solid fertilizers, typically containing urea. The nitrification inhibitor particularly can be nitrapyrin and/or DMPP. Methods of making the compositions and their use are also disclosed.

Abstract: A valve stop is provided for a valve assembly of a pump. The valve stop includes a tripod having a hub and three legs extending radially outward from the hub to end portions of the legs. The tripod is configured to be operatively connected to a valve body of the valve assembly to limit travel of the valve body. The end portions of the legs are configured to engage a wall of a fluid passage of the pump. A locator extends outward from the tripod to a handle of the locator. The handle of the locator is configured to engage an internal portion of the pump.

Abstract: A valve seat for use in a fluid end of a fracturing pump that includes a first body portion having an inner wall and an outer wall, wherein the inner wall forms a fluid bore and outer wall is configured to contact an inside surface of a fluid passageway of a fluid end of the fracturing pump for support therein. The seat further includes a second body portion extending from the first body portion, the second body having a frustro-conical portion forming a seating surface for receiving a valve. A portion of the first and second body portion includes a hardened material insert forming a portion of the seating surface and a portion of the inner wall of the first body, and further includes a metallic body portion affixed to the hardened material insert, the metallic body portion forming at least a portion of first body portion outer wall.

Abstract: A method for treatment of a cardiovascular or renal condition or disease with a specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi.