Abstract: The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Abstract: Provided are systems, methods, and computer-program products for tracking and locating shipping containers in rail car unloading operations in a railway switchyard using a rail mounted gantry crane. The systems, methods, and computer program products configured to establish the position of shipping containers loaded on rail cars within a rail yard. The position of the shipping containers can be conveyed in terms of relative or absolute coordinates. The systems, methods, and computer program products can use a variety of inputs, rules, and calculations to establish the final resting places of containers mounted on rail cars. The position information may be used to provide various functionality, including creating a log or record of the location of containers or to guide rail mounted gantry (RMG) cranes to unload and work the train(s) of interest.

Abstract: The present invention provides N-3?-pyridyl-methyl or N-2?-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X? are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Abstract: A method and apparatus for remotely performing a pipe handling operation is provided. In one aspect, the method and apparatus includes a false rotary table capable of supporting one or more tubulars during the pipe handling operation which is moveable between a position for landing one or more tubulars to a position for running one or more tubulars into a wellbore. In another aspect, the present invention provides a method and apparatus for remotely connecting elevator links alternatingly between interchangeable elevators which are capable of axially engaging one or more tubulars above the wellbore.

Abstract: The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Abstract: Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: A concrete mixer truck includes a truck chassis having a cab mounted at the front of the chassis. A mixing drum adapted to receive, mix and dispense concrete is mounted at a rear end of the chassis. The drum has a discharge end which faces the cab. A collector is located above the cab roof and is spaced apart from the mixing drum. A conveyor device mounted on a support frame is located generally between the cab and the drum and is utilized to transport concrete from the discharge end of said mixing drum up an inclined slope to the collector. A placement chute system directs a gravity flow of concrete from said collector to a desired location. The mixer truck utilizes the chassis, drum and other components of a standard rear discharge mixer truck to create a new type of front discharge mixer which has many of the advantages of existing front discharge mixer trucks at a reduced cost.

Abstract: A method and apparatus for remotely performing a pipe handling operation is provided. In one aspect, the method and apparatus includes a false rotary table capable of supporting one or more tubulars during the pipe handling operation which is moveable between a position for landing one or more tubulars to a position for running one or more tubulars into a wellbore. In another aspect, the present invention provides a method and apparatus for remotely connecting elevator links alternatingly between interchangeable elevators which are capable of axially engaging one or more tubulars above the wellbore.

Abstract: Aspects of the present invention provide a tubular handling system for handling wellbore tubulars. In one aspect, the present invention provides a tubular handling system adapted to retain a tubular without damaging the outer surface of the tubular. In another aspect, the present invention provides a method of connecting tubulars by remotely controlling the connection process, including joint compensation, alignment, make up, and interlock. In one embodiment, the tubular handling system comprises an elevator adapted to support a tubular utilizing a first portion of an upset of the tubular and a spider adapted to support the tubular utilizing a second portion of the upset. In another embodiment, at least one of the elevator and the spider is remotely controllable. In yet another embodiment, the tubular handling system comprising a joint compensator system adapted to provide fluid communication to the elevator during rotation of the tubular.

Abstract: A collapsible air vent closure is disclosed comprising a frame having a frame aperture. A closure is mounted to the frame for pivoting between a closed position and an open position. A movable vent wall having a vent orifice is interposed between the frame and the closure. The vent orifice provides an air flow path to the frame aperture when the closure is in the open position. The closure inhibits the air flow path to the frame aperture when the closure is in the closed position.