Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for optimizing network connections of media devices using IPv6 and DNS tests to detect network issues related to IPv6 addressing and improper DNS server assignments. Upon detection of such network issues, network connections may preemptively adjust IPv6 and DNS configuration parameters to optimize connections for the media devices.

Abstract: An automatic light signaling bicycle communication system includes a wireless relay module, a light module, and an external master device. The wireless relay module includes a relay processing unit and a relay communication unit. The relay processing unit controls the relay communication unit to wirelessly communicate with the external master device according to a simplified network protocol. When the relay processing unit receives a brake command through the relay communication unit according to the simplified network layer protocol file, the relay processing unit generates a relay brake command and broadcasts the relay brake command to a light communication unit of the light module according to MAC protocol, allowing a light processing unit of the light module to light up a brake light automatically. The light module only requires a low cost RF receiver chip for receiving broadcasted commands, rather than requiring an expensive chip for handling network communications.

Abstract: A driving force acceleration calculation method is executed by a processing module; the driving force acceleration calculation method includes receiving a tilt sensing signal from the tilt sensing unit, a sensed angle and a sensed acceleration from the gravity sensing unit; determining whether the tilt sensing signal is an uphill signal or a downhill signal; when determining that the tilt sensing signal is the uphill signal, calculating a driving force acceleration as the sensed acceleration plus the gravitational acceleration component; when determining that the tilt sensing signal is the downhill signal, calculating the driving force acceleration as the sensed acceleration minus the gravitational acceleration component; outputting the driving force acceleration; the method is able to more accurately calculate the driving force acceleration of a bike, therefore better knowing whether the bike suddenly decelerates.

Abstract: This disclosure is generally directed to improving path selection within a network having a single service set identifier (SSID), and more particularly, toward a media device selecting an access point from a group of access points on the same SSID based on composite metrics generated for each access point. The composite metrics may be based on network capabilities of the media device and the respective access points in the group of access points.

Abstract: A method for switching channels of communication between a host or media device and a peripheral device includes steps for detecting a trigger condition for performing a channel switch operation of a currently selected channel. The currently selected channel may be one of a plurality of channels that can be used by the media device to communicate with the peripheral device. For example, the host device may select a predefined channel (e.g., for a hard-coded channel selection) or a candidate channel (e.g., for a dynamic channel selection) from the plurality of channels. The host device may determine whether it is configured for performing a dynamic channel switch based on channel scores associated with channels in the plurality of channels.

Abstract: Debris pans and debris pan assemblies are provided. A debris pan includes a bin with an open end for receiving debris and a closed interior for containing debris. A plurality of baffles protrude from a floor of the closed interior, and the plurality of baffles may be configured to slow debris flow inside the closed interior. A debris pan assembly includes a bin, a yoke attached to the bin, and an elongated shaft attached to the yoke. The debris pan assembly also includes a latch on the bin that is selectively pivotable between a first position and a second position. The first position of the latch is configured to engage the yoke such that the bin and the yoke are rigidly positioned relative to one another. The second position of the latch is configured to disengage the yoke from the bin.

Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.

Abstract: The present invention provides novel compositions and methods for creating quantitative standards to calibrate analytes. These compositions and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers. Also provided are kits comprising the novel compositions for use in assays, for example sandwich immunoassays.

Abstract: Debris pans and debris pan assemblies are provided. A debris pan includes a bin with an open end for receiving debris and a closed interior for containing debris. A plurality of baffles protrude from a floor of the closed interior, and the plurality of baffles may be configured to slow debris flow inside the closed interior. A debris pan assembly includes a bin, a yoke attached to the bin, and an elongated shaft attached to the yoke. The debris pan assembly also includes a latch on the bin that is selectively pivotable between a first position and a second position. The first position of the latch is configured to engage the yoke such that the bin and the yoke are rigidly positioned relative to one another. The second position of the latch is configured to disengage the yoke from the bin.

Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.

Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.

Abstract: The present invention provides novel compositions and methods for creating quantitative standards to calibrate analytes. These compositions and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers. Also provided are kits comprising the novel compositions for use in assays, for example sandwich immunoassays.

Abstract: The invention relates to a package for enclosing a liquid food product. The package comprises an area having a tactile pattern for at least for indicating intended user grip and/or enhancing décor graphics. The invention also relates to a blank, a reel of blanks and a method of generating the tactile pattern.

Abstract: A gable top packaging container has a plurality of upstanding side walls including a first side wall, a front wall, a rear wall and a second side wall, wherein the front wall connects to a front gable panel and the back wall connects to a back gable panel, both extending up to a sealed top fin, the first side wall connects to a first side gable panel, and the second side wall connects to a second side gable panel, wherein the walls are separated by crease lines extending in a longitudinal direction of the packaging container, characterized in that the front wall is continuous with the front gable panel, and the back wall is continuous with the back gable panel.

Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.

Abstract: The present invention provides novel compositions and methods for creating quantitative standards to calibrate analytes. These compositions and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers. Also provided are kits comprising the novel compositions for use in assays, for example sandwich immunoassays.

Abstract: A gable top packaging container has a plurality of upstanding side walls including a first side wall, a front wall, a rear wall and a second side wall, wherein the front wall connects to a front gable panel and the back wall connects to a back gable panel, both extending up to a sealed top fin, the first side wall connects to a first side gable panel, and the second side wall connects to a second side gable panel, wherein the walls are separated by crease lines extending in a longitudinal direction of the packaging container, characterized in that the front wall is continuous with the front gable panel, and the back wall is continuous with the back gable panel.