Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: Processes are provided herein for the preparation of a bicyclic ketone compound of formula (I), or a stereoisomer thereof: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and n are as defined herein; and compounds prepared by these processes.

Abstract: The invention comprises a process for the preparation of a chiral triol of formula I wherein, R1 is hydrogen or halogen by way of an asymmetric hydrogenation of a ketone compound of formula IIa wherein, R1 is hydrogen or halogen and R2 is C1-6-alkyl; with hydrogen in the presence of an iridium spiro-pyridylamidophosphine catalyst (Ir-SpiroPAP catalyst). The chiral triols of formula I are versatile building blocks for the preparation of various pharmaceutically active drug substances such as for instance for statins.

Abstract: A redriver includes a plurality of channels coupled to an interface, a number of detectors coupled to the plurality of channels, and a controller that determines an orientation of the interface based on states detected by the number of detectors. The controller determines that the interface is in a first orientation when a first combination of states is detected for the plurality of channels, and determines that the interface is in a second orientation when a second combination of states is detected for the plurality of channels.

Abstract: A redriver includes a plurality of channels coupled to an interface, a number of detectors coupled to the plurality of channels, and a controller that determines an orientation of the interface based on states detected by the number of detectors. The controller determines that the interface is in a first orientation when a first combination of states is detected for the plurality of channels, and determines that the interface is in a second orientation when a second combination of states is detected for the plurality of channels.

Abstract: A wearable computing device can include a monopole-excited slot antenna formed by a gap between a housing (such as a highly conductive housing) and a bracket (such as a highly conductive bracket) within the highly conductive housing and by a back cavity between the highly conductive bracket and the PCB. The antenna configuration can include a monopole antenna electrically coupled to a printed circuit board and a slot antenna that is excited through coupled electromagnetic fields. The highly conductive bracket is positioned near a display window of the device, mostly below and partially enclosing a battery. The highly conductive bracket is positioned above the printed circuit board. This configuration allows for a relatively small dead band in the display window, a larger battery, compact and mechanically simple configuration, and superior water resistance.

Abstract: A security object creation and validation system provides an additional factor of authentication. An authentication system as described herein provides secure two-factor authentication, such as for IT resources in an organization. The authentication system can perform generation of a security object (such as an X.509 object, Java object, persistent browser token, or other digital certificate); registration of the generated security object or of an existing security object (such as a near field communication identifier, smart card identifier, OATH token, etc.); validation of the security object as part of an authentication process; and assertion of the identity of the security object to native network resources (such as web resources, network resources, cloud resources, mobile applications, and the like) that may accept the security object. The authentication system may provide user interfaces to allow users and administrators to manage registered device inventory and revoke security objects.

Abstract: The provisioning of a security token object to a user is disclosed. The security token object is used for accessing a computing resource through a client device, such as a mobile device. A security token object provisioning request may be received from the mobile device. In response, an authentication request may be transmitted. The user is authenticated against a user identity based upon a set of received identity credentials provided by the user. The extraction of a unique token identifier from the security token object is initiated, and completed without intervention from the user. The unique token identifier received from the client device is associated with the user identity in a data store. By providing the security token object, the user can gain access to the computing resource.

Abstract: Mechanisms for providing inductance-based user interface elements are provided. Some implementations of such inductance-based devices may feature very small gaps between the housing and the inductive coil, as well as various features to aid in improving sensor sensitivity and reducing the possibility of false button-push events.

Abstract: A device fingerprinting system provides an additional factor of authentication. A user device may be redirected, along with user ID parameters, to authentication system. The user device may be sent instructions to execute that collect and send back device characteristic information to the authentication system. The authentication can create a unique fingerprint of the device, and determine if the fingerprint has been seen before. If seen before, the authentication system may send back an authentication token indicating the additional factor of authentication was a success. If the fingerprint has not been seen previously, the authentication system may conduct a one-time password authentication as the additional factor. If successful, the fingerprint may be stored in association with the user device for future authentication as an additional factor.

Abstract: A security object creation and validation system provides an additional factor of authentication. An authentication system as described herein provides secure two-factor authentication, such as for IT resources in an organization. The authentication system can perform generation of a security object (such as an X.509 object, Java object, persistent browser token, or other digital certificate); registration of the generated security object or of an existing security object (such as a near field communication identifier, smart card identifier, OATH token, etc.); validation of the security object as part of an authentication process; and assertion of the identity of the security object to native network resources (such as web resources, network resources, cloud resources, mobile applications, and the like) that may accept the security object. The authentication system may provide user interfaces to allow users and administrators to manage registered device inventory and revoke security objects.

Abstract: A wearable computing device can include a monopole-excited slot antenna formed by a gap between a housing (such as a highly conductive housing) and a bracket (such as a highly conductive bracket) within the highly conductive housing and by a back cavity between the highly conductive bracket and the PCB. The antenna configuration can include a monopole antenna electrically coupled to a printed circuit board and a slot antenna that is excited through coupled electromagnetic fields. The highly conductive bracket is positioned near a display window of the device, mostly below and partially enclosing a battery. The highly conductive bracket is positioned above the printed circuit board. This configuration allows for a relatively small dead band in the display window, a larger battery, compact and mechanically simple configuration, and superior water resistance.

Abstract: Mechanisms for providing inductance-based user interface elements are provided. Some implementations of such inductance-based devices may feature very small gaps between the housing and the inductive coil, as well as various features to aid in improving sensor sensitivity and reducing the possibility of false button-push events.

Abstract: A wearable computing device can include a monopole-excited slot antenna formed by a gap between a housing (such as a highly conductive housing) and a bracket (such as a highly conductive bracket) within the highly conductive housing and by a back cavity between the highly conductive bracket and the PCB. The antenna configuration can include a monopole antenna electrically coupled to a printed circuit board and a slot antenna that is excited through coupled electromagnetic fields. The highly conductive bracket is positioned near a display window of the device, mostly below and partially enclosing a battery. The highly conductive bracket is positioned above the printed circuit board. This configuration allows for a relatively small dead band in the display window, a larger battery, compact and mechanically simple configuration, and superior water resistance.

Abstract: Mechanisms for providing inductance-based user interface elements are provided. Some implementations of such inductance-based devices may feature very small gaps between the housing and the inductive coil, as well as various features to aid in improving sensor sensitivity and reducing the possibility of false button-push events.

Abstract: The provisioning of a security token object to a user is disclosed. The security token object is used for accessing a computing resource through a mobile device. A security token object provisioning request may be received from the mobile device. In response, an authentication request may be transmitted. The user is authenticated against a user identity based upon a set of received identity credentials provided by the user. The extraction of a unique token identifier from the security token object is initiated, and completed without intervention from the user. The unique token identifier received from the client computer system is associated with to the user identity in a data store. By providing the security token object, the user can gain access to the computing resource.

Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

Abstract: A wearable computing device can include a monopole-excited slot antenna formed by a gap between a housing (such as a highly conductive housing) and a bracket (such as a highly conductive bracket) within the highly conductive housing and by a back cavity between the highly conductive bracket and the PCB. The antenna configuration can include a monopole antenna electrically coupled to a printed circuit board and a slot antenna that is excited through coupled electromagnetic fields. The highly conductive bracket is positioned near a display window of the device, mostly below and partially enclosing a battery. The highly conductive bracket is positioned above the printed circuit board. This configuration allows for a relatively small dead band in the display window, a larger battery, compact and mechanically simple configuration, and superior water resistance.

Abstract: A CAC/PIV certificate associated with a HSPD-12 identity is used to generate a derived credential for storage on a device, such as a mobile device, that lacks a CAC/PIV card reader. The derived credential (which is distinct from the original CAC/PIV certificate) may then be used to grant the device access to secure resources that may otherwise require a CAC/PIV certificate. Embodiments of the present disclosure also relate to systems and methods for authenticating or validating a derived credential stored on a mobile device.

Abstract: A device fingerprinting system provides an additional factor of authentication. A user device may be redirected, along with user ID parameters, to authentication system. The user device may be sent instructions to execute that collect and send back device characteristic information to the authentication system. The authentication can create a unique fingerprint of the device, and determine if the fingerprint has been seen before. If seen before, the authentication system may send back an authentication token indicating the additional factor of authentication was a success. If the fingerprint has not been seen previously, the authentication system may conduct a one-time password authentication as the additional factor. If successful, the fingerprint may be stored in association with the user device for future authentication as an additional factor.