Abstract: A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.

Abstract: A cell culture apparatus includes a cell culture module including multiple cell culture chambers. A manifold connects the multiple cell culture chambers together along a side of the cell culture module. The manifold includes a side wall base structure connected to the side of the cell culture module and a column structure that is formed as a monolithic part of the side wall base structure. The column structure defines a fluid flow pathway through the manifold and to inlets to the cell culture chambers to allow filling and emptying of the cell culture chambers of liquid medium.

Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.

Abstract: This disclosure provides a cell culture media extending material capable of releasing nutrients into the cell culture environment slowly overtime. In embodiments, this material is a part of a cell culture vessel. In embodiments, the material is a coating or a film on a surface of a cell culture material. In additional embodiments, the material is a surface upon which cells are cultured, such as a cell culture vessel or a microcarrier.

Abstract: A microcavity dish (10) for cultivating cells includes a dish body including a sidewall (16) that encloses a cell culture chamber within the dish body. The dish body has a top and a bottom (12). The bottom includes a cell culturing substrate comprising an array of microcavities (46). The sidewall includes a transition portion (30) that divides the sidewall into an upper portion and a lower portion that is offset inward relative to the upper portion defining a liquid medium delivery surface (26) that extends at least partially along an interior surface (28) of the sidewall and slopes toward the bottom.

Abstract: An incontinence product for a baby or a child or an adult. The product comprises a disposable pad that is shaped to fit around a crotch region of a person wearing the product. The product also comprises a reusable out pull-on pant having hook fasteners on the inside body of the pant to engage an outer cover stock of the disposable pad and thereby retain the pad in an operative position.

Abstract: Implant devices for implantation within an intervertebral space are provided, together with methods and tools for use therewith. Implant devices of the present invention include an implant body formed of a synthetic bone substitute material, such as a nanocrystalline calcium phosphate material. The implant body and the methods and tools used therewith are configured to optimize strength and stability of the implant, minimize areas of stress concentration in the implant body and promote bone growth through the implant body and fusion of the vertebra.

Abstract: Implant devices for implantation within an intervertebral space are provided, together with methods and tools for use therewith. Implant devices of the present invention include an implant body formed of a synthetic bone substitute material, such as a nanocrystalline calcium phosphate material. The implant body and the methods and tools used therewith are configured to optimize strength and stability of the implant, minimize areas of stress concentration in the implant body and promote bone growth through the implant body and fusion of the vertebra.

Abstract: Implant devices for implantation within an intervertebral space are provided, together with methods and tools for use therewith. Implant devices of the present invention include an implant body formed of a synthetic bone substitute material, such as a nanocrystalline calcium phosphate material. The implant body and the methods and tools used therewith are configured to optimize strength and stability of the implant, minimize areas of stress concentration in the implant body and promote bone growth through the implant body and fusion of the vertebra.

Abstract: A disposable nappy includes a disposable nappy body portion (3) and a separate belt (5) to secure the nappy body to the person. The belt includes a number of Velcro-type fastener portions that attach to a cover stock material of the nappy. The cover stock material is of a material that includes fibers that can retain the Velcro-type fasteners. Also defined are leg guards (19) formed from outer edges of a laminate cover layer.

Abstract: A pouch for an absorbent pad is disclosed. The pouch (3) comprises a sheet of waterproof fabric formed into a pouch shape with a base (5) and a side wall (7) that extends from the base and is inwardly turned and defines an opening to insert a pad into the pouch so that the pouch covers the back and sides of the pad. In use, an assembly of the pouch and the pad received in the pouch can be positioned in a crotch region of an adult, child or baby in an operative position of the pad and with the pouch and the skin of the person enclosing the pad and forming a barrier to leakage from the pad.

Abstract: A disposable nappy includes a disposable nappy body portion (3) and a separate belt (5) to secure the nappy body to the person. The belt includes a number of Velcro-type fastener portions that attach to a cover stock material of the nappy. The cover stock material is of a material that includes fibres that can retain the Velcro-type fasteners. Also defined are leg guards (19) formed from outer edges of a laminate cover layer.

Abstract: Implant devices for implantation within an intervertebral space are provided, together with methods and tools for use therewith. Implant devices of the present invention include an implant body formed of a synthetic bone substitute material, such as a nanocrystalline calcium phosphate material. The implant body and the methods and tools used therewith are configured to optimize strength and stability of the implant, minimize areas of stress concentration in the implant body and promote bone growth through the implant body and fusion of the vertebra.

Abstract: A pouch for an absorbent pad is disclosed. The pouch (3) comprises a sheet of waterproof fabric formed into a pouch shape with a base (5) and a side wall (7) that extends from the base and is inwardly turned and defines an opening to insert a pad into the pouch so that the pouch covers the back and sides of the pad. In use, an assembly of the pouch and the pad received in the pouch can be positioned in a crotch region of an adult, child or baby in an operative position of the pad and with the pouch and the skin of the person enclosing the pad and forming a barrier to leakage from the pad.

Abstract: A garment for use with an absorbent product such as sanitary napkins and cloth or disposable nappies or pads for babies and incontinent children and adults is disclosed. The garment is adapted to fit around the crotch of a user to hold the absorbent product against the user. The garment includes a layer (3) of liquid-resistant or liquid-impervious material to contact the outer surface of the absorbent product to minimize leakage of body fluids. The layer (3) is characterized by darts (15) extending along the sides of the garment that define leg openings to minimize lateral movement of the absorbent product with respect to the garment and to form wet guards to minimize leakage of body fluids through the leg openings. In a preferred embodiment the garment also includes hook and loop fasteners (13) to releasably hold the garment around the waist of the user which are arranged so that the fastening is to the rear of the user.