Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.

Abstract: Embodiments of the present invention encompass graft assemblies, and methods for their use and manufacture. An exemplary bone graft assembly includes first and second bone pieces having respective mating features which, when combined, define non-uniform press fit. Related embodiments encompass graft assemblies having enclosed or hidden mating features.

Abstract: Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch.

Abstract: There is disclosed a constant force compression tool for measuring a compressible material. In an embodiment, the tool includes a handle having a passageway receiving a plunger. The tool includes a biasing member in communication with the plunger and the handle. The tool includes a retaining element in communication with the plunger and the handle. There is disclosed a system for measuring a compressible material with a measurement tube and a constant force compression tool. There is disclosed a method of measuring a compressible material. In an embodiment, the method includes selecting a measurement tube. The method includes placing a compressible material into the measurement tube. The method includes pressing a plunger against the compressible material. The method includes monitoring an indicator to determine a full volume of compressible material between the end of the plunger and the conical tube. Other embodiments are also disclosed.