Abstract: An articulation joint includes proximal links, distal links, and intermediate links connecting the proximal and distal links. The articulation joint has a straight configuration along a straight longitudinal axis, a first bent configuration when the articulation joint bends toward a first side of the longitudinal axis, and a second bent configuration when the articulation joint bends toward a second side of the longitudinal axis, opposite to the first side. When the articulation joint is in the straight configuration, a first gap is defined at the first side between adjacent proximal links, and the adjacent proximal links contact each other at the second side, a second gap is defined at each of the first side and the second side between adjacent distal links, and a third gap is defined at the first side between adjacent intermediate links, and adjacent intermediate links contact each other at the second side.

Abstract: An articulation joint includes proximal links, distal links, and intermediate links connecting the proximal and distal links. The articulation joint has a straight configuration along a straight longitudinal axis, a first bent configuration when the articulation joint bends toward a first side of the longitudinal axis, and a second bent configuration when the articulation joint bends toward a second side of the longitudinal axis, opposite to the first side. When the articulation joint is in the straight configuration, a first gap is defined at the first side between adjacent proximal links, and the adjacent proximal links contact each other at the second side, a second gap is defined at each of the first side and the second side between adjacent distal links, and a third gap is defined at the first side between adjacent intermediate links, and adjacent intermediate links contact each other at the second side.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments of the present disclosure are directed to cannulating devices and methods for exchanging cannulating devices in an endoscopic procedure. In one implementation, an apparatus for endoscopic operations is described. The apparatus includes a cannulating device to be introduced through an internal lumen of an endoscope via a biopsy port. The cannulating device has an elongated body. The elongated body includes a guidewire lumen configured to receive a guidewire therein, and a slit extending over at least a portion of the length of the elongated body from a distal tip to a proximal position of the elongated body.

Abstract: Embodiments of the present disclosure are directed to apparatuses, systems, and methods for merging a balloon catheter onto a locked guidewire. In one implementation, a balloon catheter may include an inflatable balloon affixed thereto and a slit extending from a distal end of a guidewire lumen to a position proximal of the balloon. The slit may be widened by a working member of an adapter to allow passage of the locked guidewire into the guidewire lumen of the balloon catheter. The balloon catheter may be merged onto the guidewire via the slit and delivered to the desired treatment device without requiring the guidewire to be unlocked. Advantageously, access to at least one desired treatment site may be maintained with the guidewire during merging of the balloon catheter.

Abstract: Embodiments of the present disclosure are directed to apparatuses, systems, and methods for merging an endoscopic basket delivery catheter onto a fixed guidewire. In one implementation, a catheter may include a sheath having a saddle secured to a distal portion thereof. The sheath may constrain an endoscopic tool such as a basket therein, while the saddle may receive a portion of a guidewire. The saddle may include a slit extending along its longitudinal length. The slit may be widened by a working member of an adapter to allow passage of a locked guidewire into the guidewire lumen of the saddle. The catheter may be merged onto the guidewire via the slit and delivered to the desired treatment device without unlocking of the guidewire. Advantageously, access to at least one desired treatment site may be maintained with the guidewire during merging of the catheter.

Abstract: An articulation joint includes proximal links, distal links, and intermediate links connecting the proximal and distal links. The articulation joint has a straight configuration along a straight longitudinal axis, a first bent configuration when the articulation joint bends toward a first side of the longitudinal axis, and a second bent configuration when the articulation joint bends toward a second side of the longitudinal axis, opposite to the first side. When the articulation joint is in the straight configuration, a first gap is defined at the first side between adjacent proximal links, and the adjacent proximal links contact each other at the second side, a second gap is defined at each of the first side and the second side between adjacent distal links, and a third gap is defined at the first side between adjacent intermediate links, and adjacent intermediate links contact each other at the second side.

Abstract: Embodiments of the present disclosure are directed to systems and methods for device exchange in an endoscopic procedure. In one implementation, a system for device exchange in an endoscopic procedure includes an elongated device having a slit extending from a distal end to a proximal end of the elongated device, a main block, and an adapter. The main block is configured to be affixed to a port of an endoscope. The main block includes a main channel for receiving a guidewire and the elongated device. The adapter can be engaged with the main block and configured to merge the guidewire into the elongated device. The adapter includes a working channel for receiving the elongated device and a working member raising from an inner wall of the working channel. When the elongated device passes through the working channel, the working member wedges open a portion of the slit of the elongated device such that a portion of the guidewire merges into the elongated device through the opened portion of the slit.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments of the present disclosure are directed to apparatuses, systems, and methods for merging a balloon catheter onto a locked guidewire. In one implementation, a balloon catheter may include an inflatable balloon affixed thereto and a slit extending from a distal end of a guidewire lumen to a position proximal of the balloon. The slit may be widened by a working member of an adapter to allow passage of the locked guidewire into the guidewire lumen of the balloon catheter. The balloon catheter may be merged onto the guidewire via the slit and delivered to the desired treatment device without requiring the guidewire to be unlocked. Advantageously, access to at least one desired treatment site may be maintained with the guidewire during merging of the balloon catheter.

Abstract: Embodiments of the present disclosure are directed to apparatuses, systems, and methods for merging an endoscopic basket delivery catheter onto a fixed guidewire. In one implementation, a catheter may include a sheath having a saddle secured to a distal portion thereof. The sheath may constrain an endoscopic tool such as a basket therein, while the saddle may receive a portion of a guidewire. The saddle may include a slit extending along its longitudinal length. The slit may be widened by a working member of an adapter to allow passage of a locked guidewire into the guidewire lumen of the saddle. The catheter may be merged onto the guidewire via the slit and delivered to the desired treatment device without unlocking of the guidewire. Advantageously, access to at least one desired treatment site may be maintained with the guidewire during merging of the catheter.

Abstract: Embodiments of the present disclosure are directed to devices and methods for object retrieval in a body lumen. In some embodiments, disclosed herein is a retrieval device including a catheter; a strut shaft; a basket comprising a plurality of struts and a collapsible pouch; and an actuation mechanism.

Abstract: Embodiments of the present disclosure are directed to cannulating devices and methods for exchanging cannulating devices in an endoscopic procedure. In one implementation, an apparatus for endoscopic operations is described. The apparatus includes a cannulating device to be introduced through an internal lumen of an endoscope via a biopsy port. The cannulating device has an elongated body. The elongated body includes a guidewire lumen configured to receive a guidewire therein, and a slit extending over at least a portion of the length of the elongated body from a distal tip to a proximal position of the elongated body.

Abstract: Embodiments of the present disclosure are directed to systems and methods for device exchange in an endoscopic procedure. In one implementation, a system for device exchange in an endoscopic procedure includes an elongated device having a slit extending from a distal end to a proximal end of the elongated device, a main block, and an adapter. The main block is configured to be affixed to a port of an endoscope. The main block includes a main channel for receiving a guidewire and the elongated device. The adapter can be engaged with the main block and configured to merge the guidewire into the elongated device. The adapter includes a working channel for receiving the elongated device and a working member raising from an inner wall of the working channel. When the elongated device passes through the working channel, the working member wedges open a portion of the slit of the elongated device such that a portion of the guidewire merges into the elongated device through the opened portion of the slit.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments of the invention relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide pull-out resistance, stability and/or maximize contact with tissue involving a minimum amount of penetration. In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces.

Abstract: Embodiments relate generally to tissue anchors and methods of delivering same to the intervertebral disc or other sites within the body. In some embodiments, the anchors provide increased pull-out resistance, stability and/or contact with tissue involving a reduced amount of penetration. In some embodiments, delivery methods are minimally invasive and can include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces. Several embodiments disclose anchors and anchoring systems that effectively reconstruct or augment vertebral endplate surfaces.