Patents by Inventor Almuth Marx

Almuth Marx has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the prognosis of breast cancer
    Patent number: 9017944
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: April 28, 2015
    Assignee: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John W. Martens, Fabian Model, Inko Nimmrich, Manfred Schmitt, Ralf Lesche, Dimo Dietrich, Volkmar Mueller, Antje Kluth Lukas, Ina Schwope, Oliver Hartmann, Peter Adorjan, Almuth Marx, Heinz Hoefler
  • Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders
    Publication number: 20120184455
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 19, 2012
    Applicant: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John Martens, Fabian Model, Inko Nimmrich, Tamas Rujan, Armin Schmitt, Manfred Schmitt, Maxime P. Look, Almuth Marx, Heinz Hoefler
  • Method for determining risk of relapse of breast cancer following tamoxifen adjuvant therapy
    Patent number: 8101359
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: January 24, 2012
    Assignee: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John W. Martens, Fabian Model, Inko Nimmrich, Tamas Rujan, Armin Schmitt, Manfred Schmitt, Maxime P. Look, Almuth Marx, Heinz Hoefler
  • Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
    Publication number: 20090269736
    Abstract: Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
    Type: Application
    Filed: June 6, 2005
    Publication date: October 29, 2009
    Applicant: Epigenomics AG
    Inventors: Inko Nimmrich, Ralf Lesche, Ina Schwope, Sabine Maier, Antje Kluth Lukas, Oliver Hartmann, Almuth Marx
  • Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders
    Publication number: 20080254447
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Application
    Filed: December 13, 2004
    Publication date: October 16, 2008
    Applicant: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John Martens, Fabian Model, Inko Nimmrich, Manfred Schmitt, Ralf Lesche, Dimo Dietrich, Volkmar Mueller, Antje Kluth, Ina Schwope, Oliver Hartmann, Peter Adorjan, Almuth Marx, Heinz Hoefler
  • Method and nucleic acids for the improved treatment of breast cell proliferative disorders
    Publication number: 20060121467
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Application
    Filed: October 1, 2003
    Publication date: June 8, 2006
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John Martens, Fabian Model, Inko Nimmrich, Tamas Rujan, Armin Schmitt, Manfred Schmitt, Maxime Look, Almuth Marx, Heinz Hoefler