Patents by Inventor Alois Jungbauer

Alois Jungbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230017907
    Abstract: The present invention relates to a method for continuous recovering of a protein from a fluid, comprising precipitating the protein in the fluid and separating the precipitated protein from the fluid. The invention also provides an inclined plate settler that can be used for such continuous protein recovering.
    Type: Application
    Filed: December 10, 2020
    Publication date: January 19, 2023
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Daniel FLEISCHANDERL, Christoph DATTENBOECK, Katerina PETRUSHEVSKA-SEEBACH, Thomas GATTERNIG, Martin PURTSCHER, Alois JUNGBAUER, Hannah ENGELMAIER, Nikolaus HAMMERSCHMIDT
  • Publication number: 20220380739
    Abstract: The invention refers to a single-chain circular permuted caspase-2 comprising the following structure from N- to C-terminus: i) a small subunit of a caspase-2, or a functionally active variant thereof; and ii) a large subunit of a caspase-2, or a functionally active variant thereof, wherein said cp caspase-2 comprises one or more amino acid substitutions increasing P1? tolerance of said cp caspase-2 compared to a cp caspase-2 without said amino acid substitutions.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 1, 2022
    Inventors: Alois JUNGBAUER, Nico LINGG, Gerald STRIEDNER, Monika CSERJAN-PUSCHMANN, Chris OOSTENBRINK, Christoph OEHLKNECHT, Christina KROESS, Petra ENGELE, Rainer SCHNEIDER
  • Publication number: 20220380718
    Abstract: A system and a method for on-demand reconstituting solid process material is disclosed. The system comprises a feeding device for continuously feeding said solid process material, a mixing vessel, optionally a hold tank, optionally one or more mixing reactors, and optionally a sterile filter unit, wherein the system is configured to operate continuously.
    Type: Application
    Filed: December 18, 2020
    Publication date: December 1, 2022
    Inventors: Daniel KOMUCZKI, Peter SATZER, Alois JUNGBAUER
  • Publication number: 20210254021
    Abstract: Provided is a method for producing and/or purifying measles virus (MV) particles from a sample, the method comprising in sequential order the following steps loading a sample containing MV particles and one or more impurities onto a stationary phase material for carrying out flow-through chromatography to bind at least a fraction of the impurities contained in the sample and to produce a flow-through comprising at least a fraction of the MV particles contained in the sample; carrying out filtration, preferably ultrafiltration, and obtaining a retentate having an increased MV titer relative to the MV titer comprised in the flow-through. Further provided is a system for producing and/or purifying MV particles, comprising at least one bioreactor; a clarification unit, preferably a dead end filter unit, downstream to the bioreactor; a flow through chromatography unit downstream to the clarification unit; and a filtration unit, downstream to the flow through chromatography unit.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 19, 2021
    Inventors: Patrick CSAR, Alois JUNGBAUER, Alexander KORT, Matthias M√úLLNER, Dieter PALMBERGER, Katrin RAMSAUER, Sabrina SCHRAUF, Petra STEPPERT, Erich TAUBER, David A. MAIER, Jochen STRITZKER
  • Patent number: 11090583
    Abstract: This disclosure relates to a bottom section for being connected to an assembly for separating a solid component from a fluid. The assembly includes an inclined plate settler with at least one sedimentation channel for letting a solid component to be separated settle, said plate settler comprising a lower portion and an upper portion, wherein said at least one sedimentation channel extends from the lower portion to the upper portion. The bottom section is configured to be connected to the lower portion of the inclined plate settler. The bottom section comprises at least one inlet channel for feeding a fluid comprising the solid component to be separated to the plate settler, and at least one collection channel for collecting a settled solid component descending from the at least one sedimentation channel.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: August 17, 2021
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Nikolaus Hammerschmidt, Alois Jungbauer, Hannah Engelmaier
  • Publication number: 20210149361
    Abstract: The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.
    Type: Application
    Filed: April 4, 2017
    Publication date: May 20, 2021
    Inventors: Alois Jungbauer, Astrid Durauer, Nicole Walch, Dominik Sauer, Theresa Scharl-Hirsch, Michael Melcher, Friedrich Leisch
  • Patent number: 10661264
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 26, 2020
    Assignees: BOEHRINGER INGELHEIM RCV GMBH & CO KG, SANDOZ AG
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
  • Patent number: 10537887
    Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: January 21, 2020
    Assignees: BOEHRINGER INGELHEIM RCV & GMBH CO KG, SANDOZ AG
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov, Moritz Imendoerffer
  • Publication number: 20200016515
    Abstract: This disclosure relates to a bottom section for being connected to an assembly for separating a solid component from a fluid. The assembly includes an inclined plate settler with at least one sedimentation channel for letting a solid component to be separated settle, said plate settler comprising a lower portion and an upper portion, wherein said at least one sedimentation channel extends from the lower portion to the upper portion. The bottom section is configured to be connected to the lower portion of the inclined plate settler. The bottom section comprises at least one inlet channel for feeding a fluid comprising the solid component to be separated to the plate settler, and at least one collection channel for collecting a settled solid component descending from the at least one sedimentation channel.
    Type: Application
    Filed: June 18, 2019
    Publication date: January 16, 2020
    Applicants: Baxalta Incorporated, Baxalta GmbH
    Inventors: Nikolaus HAMMERSCHMIDT, Alois JUNGBAUER, Hannah ENGELMAIER
  • Patent number: 10508133
    Abstract: This application relates to methods for purification of proteins such as antibodies using a hydrophilic polymer (e.g., PEG), a fatty acid (e.g., caprylic acid), and/or another agent (e.g., calcium chloride).
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: December 17, 2019
    Assignee: NOVASEP PROCESS
    Inventors: Alois Jungbauer, Ralf Sommer
  • Patent number: 10501525
    Abstract: This disclosure relates to methods for isolating antibodies from cell-free culture supernatant.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: December 10, 2019
    Assignee: Novartis AG
    Inventors: Alois Jungbauer, Peter Satzer, Anne-Luise Tscheliessnig
  • Publication number: 20190366236
    Abstract: The present invention provides a novel process for desalting protein solutions using micropore anion and cation exchange resins. In addition, a continuous process for desalting biopharmaceutical solutions was developed. Devices for use in the process for desalting biopharmaceutical solutions were also developed.
    Type: Application
    Filed: November 10, 2017
    Publication date: December 5, 2019
    Inventors: Nicole Walch, Alois Jungbauer
  • Publication number: 20190046969
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Application
    Filed: August 14, 2018
    Publication date: February 14, 2019
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
  • Publication number: 20190022654
    Abstract: The present invention relates a method for incubating liquids, to a method for preparing a biopharmaceutical drug, and to a device for the preparation of a biopharmaceutical drug.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 24, 2019
    Applicants: Baxalta Incorporated, Baxalta GmbH
    Inventors: Nikolaus HAMMERSCHMIDT, Jure SENCAR, Alois JUNGBAUER, Duarte Lima MARTINS
  • Patent number: 10076749
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: September 18, 2018
    Assignees: BOEHRINGER INGELHEIM RCV GMBH & CO KG, SANDOZ AG
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
  • Publication number: 20160340384
    Abstract: Disclosed is a method for refolding recombinantly produced polypeptides comprising the steps of (a)providing inclusion bodies comprising recombinantly produced polypeptides comprising the recombinantly produced polypeptides, (b)dissolving the inclusion bodies under chaotropic conditions in so as to obtain denatured recombinantly produced polypeptides, and (c)refolding the denatured recombinantly produced polypeptides inclusion bodies by addition of a refolding buffer,so as to obtain refolded re-combinantly produced polypeptides, and (d) further processing the refolded recombinantly produced polypeptides by at least one processing step, wherein at least steps (c) and (d) are performed in a tubular reactor in a continuous manner.
    Type: Application
    Filed: December 22, 2014
    Publication date: November 24, 2016
    Applicant: SANDOZ AG
    Inventors: Alois JUNGBAUER, Pan SIQI, Monika ZELGER, Rainer HAHN
  • Publication number: 20160272675
    Abstract: This application relates to methods for purification of proteins such as antibodies using a hydrophilic polymer (e.g., PEG), a fatty acid (e.g., caprylic acid), and/or another agent (e.g., calcium chloride).
    Type: Application
    Filed: October 17, 2014
    Publication date: September 22, 2016
    Applicant: Universitat Fur Bodenkultur Wein
    Inventors: Alois Jungbauer, Ralf Sommer
  • Publication number: 20160200760
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Application
    Filed: August 25, 2014
    Publication date: July 14, 2016
    Inventors: Rainer HAHN, Alois JUNGBAUER, Alexandru TREFILOV
  • Publication number: 20160193598
    Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.
    Type: Application
    Filed: August 25, 2013
    Publication date: July 7, 2016
    Applicant: Boehringer Ingelhelim RCV GMBH & Co KG
    Inventors: Rainer HAHN, Alois JUNGBAUER, Alexandru TREFILOV, Moritz IMENDOERFFER
  • Publication number: 20160151747
    Abstract: The invention relates to an isolated waterproof polymeric nanomembrane comprising pores of different geometric shapes and of a controlled size between 10 and 1000 nm, which is larger than the thickness of the membrane, and a method of producing the same comprising the process steps a. Providing a sacrifice layer on a surface of a solid support; b. Providing a polymerized layer of less than 1000 nm thickness on the surface of the sacrifice layer, by depositing a mixture of a polymer or a polymer precursor with a geometrically undefined pore template which is larger than the thickness of the polymerized layer, optionally followed by polymerization and/or crosslinking; c. Removing the pore template to obtain the polymerized layer with a controlled pore size; and d. Removing the sacrifice layer, thereby separating the solid support from the polymerized layer.
    Type: Application
    Filed: June 10, 2014
    Publication date: June 2, 2016
    Applicants: ACIB GMBH, UNIVERSITAT FUR BODENKULTUR WIEN
    Inventors: Alois Jungbauer, Agnes Rodler, Gerhard Sekot, Rupert Tscheliessnig