Patents by Inventor Alojz Skoda

Alojz Skoda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of carvedilol
    Patent number: 7534895
    Abstract: The invention solves a new method of preparation of Carvedilol for pharmaceutical use. In the synthesis of Carvedilol a reaction of 4-(oxirane-2-ylmethoxy)-9H-arbazole (II) with 2-(2-methoxyphenoxy)ethylamine salts (IV) in the presence of a base, in an alcohol having the number of carbons C2 to C5 as a solvent, at an elevated temperature, is used. After processing of the crude reaction mixture crude Carvedilol is obtained, which is purified by crystallization from ethylacetate with an addition of activated carbon and the final substance is formulated by crystallization from ethylacetate.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: May 19, 2009
    Assignee: Zentiva, A.S.
    Inventors: Richard Hercek, Alojz Skoda, Bohumil Proksa
  • Process for preparation of carvedilol
    Publication number: 20060167077
    Abstract: The invention solves a new method of preparation of Carvedilol for pharmaceutical use. In the synthesis of Carvedilol a reaction of 4-(oxirane-2-ylmethoxy)-9H-arbazole (II) with 2-(2-methoxyphenoxy)ethylamine salts (IV) in the presence of a base, in an alcohol having the number of carbons C2 to C5 as a solvent, at an elevated temperature, is used. After processing of the crude reaction mixture crude Carvedilol is obtained, which is purified by crystallization from ethylacetate with an addition of activated carbon and the final substance is formulated by crystallization from ethylacetate.
    Type: Application
    Filed: November 4, 2003
    Publication date: July 27, 2006
    Applicant: ZENTIVA, A.S.
    Inventors: Richard Hercek, Alojz Skoda, Bohumil Proksa