Patents by Inventor Alok Kumar Awasthi
Alok Kumar Awasthi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11873361Abstract: An ophthalmic device for slowing, inhibiting or preventing myopia progression which is a polymerization product of a monomeric mixture comprising (a) greater than 50 wt. %, based on the total weight of the monomeric mixture, of one or more non-silicone-containing hydrophilic monomers; (b) one or more crosslinking agents; and (c) one or more red-light blocking compounds blocking greater than 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 800 nm, wherein the one or more red-light blocking compounds have one or more ethylenically unsaturated reactive end groups.Type: GrantFiled: June 9, 2022Date of Patent: January 16, 2024Assignee: BAUSCH + LOMB IRELAND LIMITEDInventors: Alok Kumar Awasthi, Kristen Rae Hovinga, Emily Abrams Gabriel, Kevin Jacob DeRyke, Jade J. Russell, James Anthony DiBella, Jr., Alana Ingham
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Publication number: 20230407077Abstract: A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.Type: ApplicationFiled: September 6, 2023Publication date: December 21, 2023Inventors: James Anthony DiBella, JR., Alok Kumar Awasthi, Jade J. Russell, Mark R. Mis, James Hauenstein, Mark Fomalik, Andrew J. Hoteling, Shawn M. Conlon, Kaushiendra Kumar
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Patent number: 11845813Abstract: A packaging system for the storage of an ophthalmic device includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked polymeric networks. The one or more crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan. The aqueous packaging solution has an osmolality of at least about 180 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.Type: GrantFiled: June 21, 2022Date of Patent: December 19, 2023Assignee: Bausch & Lomb IncorporatedInventors: George L Grobe, III, Alok Kumar Awasthi, Mark R. Mis, Jennah L. Wolcott, James R. Hauenstein
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Patent number: 11795320Abstract: A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.Type: GrantFiled: September 16, 2020Date of Patent: October 24, 2023Assignee: BAUSCH + LOMB IRELAND LIMITEDInventors: James Anthony DiBella, Jr., Alok Kumar Awasthi, Jade J. Russell, Mark R. Mis, James Hauenstein, Mark Fornalik, Andrew J. Hoteling, Shawn M. Conlon, Kaushlendra Kumar
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Publication number: 20230266505Abstract: An ophthalmic device which is a polymerization product of a monomeric mixture includes (a) one or more cationic initiators comprising one or more polymerizable groups; and (b) one or more alkyl-substituted oxazolines.Type: ApplicationFiled: January 31, 2023Publication date: August 24, 2023Inventors: Feng-Yang Shih, Mohammad Vatankhah Varnosfaderani, Alok Kumar Awasthi
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Patent number: 11732060Abstract: A crosslinked polymeric network is disclosed. The crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan.Type: GrantFiled: January 10, 2020Date of Patent: August 22, 2023Assignee: BAUSCH & LOMB INCORPORATEDInventors: George L. Grobe, III, Alok Kumar Awasthi, Mark R. Mis, Jennah L. Wolcott, James R. Hauenstein
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Publication number: 20230257485Abstract: A biomedical device having a coating on a surface thereof, where the coating includes a glycophospholipid polymer which is a reaction product of one or more glycosaminoglycans and one or more phospholipids.Type: ApplicationFiled: April 26, 2023Publication date: August 17, 2023Inventors: Alok Kumar Awasthi, James Anthony DiBella, JR., Mark R. Mis, Alai Musleh, George L. Grobe, III
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Publication number: 20230244000Abstract: A multifunctional crosslinking agent includes one or more repeating units of a siloxanyl group or a silyl-alkyl-siloxanyl group, and at least two ethylenically unsaturated reactive end groups. One of the at least two ethylenically unsaturated reactive end groups is a (meth)acrylate-containing reactive end group or an acrylamide-containing reactive end group and the other one is an allyl-containing reactive end group or a vinyl-containing reactive end group.Type: ApplicationFiled: January 25, 2023Publication date: August 3, 2023Inventors: Alok Kumar Awasthi, Feng-Yang Shih, Mohammad Vatankhah Varnosfaderani, James Anthony DiBella, JR., Mark R. Mis, Jade J. Russell
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Patent number: 11673974Abstract: A glycophospholipid polymer is disclosed. The glycophospholipid polymer comprises a reaction product of one or more glycosaminoglycans and one or more phospholipids. Also disclosed is a glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans, one or more phospholipids and, one or more crosslinking agents.Type: GrantFiled: March 11, 2020Date of Patent: June 13, 2023Assignee: BAUSCH & LOMB INCORPORATEDInventors: Alok Kumar Awasthi, James Anthony DiBella, Jr., Mark R. Mis, Alai Musleh, George L. Grobe, III
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Patent number: 11660370Abstract: A packaging system for storing ophthalmic devices such as contact lenses and methods for packaging such ophthalmic devices with solutions is disclosed. The packaging system contains an unused, ophthalmic device in an aqueous packaging solution comprising tris(hydroxymethyl)aminomethane or a salt thereof; wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9.Type: GrantFiled: December 14, 2021Date of Patent: May 30, 2023Assignee: BAUSCH & LOMB INCORPORATEDInventors: Alok Kumar Awasthi, Erning Xia, Jennah L. Wolcott, Ruth Julian
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Publication number: 20230097637Abstract: A method for preparing an ophthalmic device for slowing, inhibiting or preventing myopia progression involves (a) soaking an ophthalmic device in one or more first solvent solutions to swell the ophthalmic device; (b) soaking the swelled ophthalmic device in one or more second solvents solutions comprising one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm to de-swell the swelled ophthalmic device and entrap the one or more red-light blocking compounds in the de-swelled ophthalmic device; and (c) sterilizing the de-swelled ophthalmic device.Type: ApplicationFiled: June 9, 2022Publication date: March 30, 2023Inventors: Alok Kumar Awasthi, Kristen Rae Hovinga, Emily Abrams Gabriel, Kevin Jacob DeRyke, Jade J. Russell, Alana Ingham
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Publication number: 20230096315Abstract: A method for preparing an ophthalmic device for slowing, inhibiting or preventing myopia progression involves contacting an ophthalmic device having one or more reactive functional groups with one or more red-light blocking compounds having one or more reactive functional groups complementary to the one or more reactive functional groups of the ophthalmic device in a basic solution for a time period sufficient to covalently bond at least one reactive functional group of the ophthalmic device with at least one reactive functional group of the one or more red-light blocking compounds. The one or more red-light blocking compounds block greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm.Type: ApplicationFiled: June 9, 2022Publication date: March 30, 2023Inventors: Alok Kumar Awasthi, Kristen Rae Hovinga, Emily Abrams Gabriel, Kevin Jacob DeRyke, Jade J. Russell
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Publication number: 20230089707Abstract: An ophthalmic device for slowing, inhibiting or preventing myopia progression which is a polymerization product of a monomeric mixture comprising (a) greater than 50 wt. %, based on the total weight of the monomeric mixture, of one or more non-silicone-containing hydrophilic monomers; (b) one or more crosslinking agents; and (c) one or more red-light blocking compounds blocking greater than 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 800 nm, wherein the one or more red-light blocking compounds have one or more ethylenically unsaturated reactive end groups.Type: ApplicationFiled: June 9, 2022Publication date: March 23, 2023Inventors: Alok Kumar Awasthi, Kristen Rae Hovinga, Emily Abrams Gabriel, Kevin Jacob DeRyke, Jade J. Russell, James Anthony DiBella, JR., Alana Ingham
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Publication number: 20230047871Abstract: A biomedical device is disclosed. The biomedical device includes a polymerization product of a biomedical device-forming mixture containing (a) one or more grafted glycosaminoglycan polymers including a glycosaminoglycan having a polymer backbone and one or more side chains comprising an ethylenically unsaturated reactive-containing residue grafted onto the polymer backbone, and (b) one or more non-silicone biomedical device-forming monomers.Type: ApplicationFiled: May 31, 2022Publication date: February 16, 2023Inventors: James Anthony DiBella, JR., Feng-Yang Shih, Mark R. Mis, Lindsey Cullen, Sandra Taft, Alok Kumar Awasthi
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Publication number: 20220325006Abstract: A packaging system for the storage of an ophthalmic device includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked polymeric networks. The one or more crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan.Type: ApplicationFiled: June 21, 2022Publication date: October 13, 2022Inventors: George L. Grobe III, Alok Kumar Awasthi, Mark R. Mis, Jennah L. Wolcott, James R. Hauenstein
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Patent number: 11421047Abstract: A packaging system for the storage of an ophthalmic device includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked polymeric networks. The one or more crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan. The aqueous packaging solution has an osmolality of at least about 180 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.Type: GrantFiled: November 23, 2021Date of Patent: August 23, 2022Assignee: Bausch & Lomb IncorporatedInventors: George L. Grobe, III, Alok Kumar Awasthi, Mark R. Mis, Jennah L. Wolcott, James R. Hauenstein
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Publication number: 20220105230Abstract: A packaging system for storing ophthalmic devices such as contact lenses and methods for packaging such ophthalmic devices with solutions is disclosed. The packaging system contains an unused, ophthalmic device in an aqueous packaging solution comprising tris(hydroxymethyl)aminomethane or a salt thereof; wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9.Type: ApplicationFiled: December 14, 2021Publication date: April 7, 2022Inventors: Alok Kumar Awasthi, Erning Xia, Jennah L. Wolcott, Ruth Julian
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Publication number: 20220081491Abstract: A packaging system for the storage of an ophthalmic device includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked polymeric networks. The one or more crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan.Type: ApplicationFiled: November 23, 2021Publication date: March 17, 2022Inventors: George L. Grobe III, Alok Kumar Awasthi, Mark R. Mis, Jennah L. Wolcott, James R. Hauenstein
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Patent number: 11253625Abstract: A packaging system for storing ophthalmic devices such as contact lenses and methods for packaging such ophthalmic devices with solutions is disclosed. The packaging system contains an unused, ophthalmic device in an aqueous packaging solution comprising tris(hydroxymethyl)aminomethane or a salt thereof; wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9.Type: GrantFiled: May 21, 2019Date of Patent: February 22, 2022Assignee: Bausch & Lomb IncorporatedInventors: Alok Kumar Awasthi, Erning Xia, Jennah L. Wolcott, Ruth Julian
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Patent number: 11066530Abstract: A method for preparing an ophthalmic device containing an ultraviolet (UV) blocker is disclosed. The method involves (a) soaking an ophthalmic device in one or more first solvent solutions to swell the ophthalmic device; (b) soaking the swelled ophthalmic device in one or more second solvents solutions comprising a UV blocker to de-swell the ophthalmic device and entrap the UV blocker in the ophthalmic device, wherein the UV blocker is a benzotriazole and (c) sterilizing the de-swelled ophthalmic device.Type: GrantFiled: March 22, 2019Date of Patent: July 20, 2021Assignee: Bausch & Lomb IncorporatedInventors: James Anthony DiBella, Jr., George L. Grobe, III, Alok Kumar Awasthi