Abstract: Systems and methods for presence ground truth approximation and utilization are disclosed. For example, a system detects the presence of a predefined subject, such as a person associated with a given user profile, and/or determines that authentication criteria for performing an action in association with the user profile has been satisfied. A period of time to associate data is determined, and data of one or more data types is labeled as being associated with the speaker identification event. That data may be formatted and input into one or more models to train those models to more accurately detect presence and/or determine whether authentication of a user profile should succeed.

Abstract: A virtual network provider system supports a virtual network including virtual machines that are each assigned to an underlay address of an underlay addressing scheme. The virtual network provider system further includes multiple routing domains each defined to include a different subset of the virtual machines. Each of the routing domains is assigned to a range of overlay addresses of an overlay addressing scheme. For each routing domain, the assigned range of overlay addresses is allocated among the subset of the virtual machines in the routing domain. The system further includes a virtual network host configured to use addresses of the overlay addressing scheme to selectively route messages between endpoints on select pairs of the virtual machines assigned to a same routing domain of the plurality of routing domains.

Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.

Abstract: Systems and methods for presence ground truth approximation and utilization are disclosed. For example, a system detects the presence of a predefined subject, such as a person associated with a given user profile, and/or determines that authentication criteria for performing an action in association with the user profile has been satisfied. A period of time to associate data is determined, and data of one or more data types is labeled as being associated with the speaker identification event. That data may be formatted and input into one or more models to train those models to more accurately detect presence and/or determine whether authentication of a user profile should succeed.

Abstract: The present invention provides workflows for the discovery of nonallosteric sirtuin activation compounds. Workflows enable drug discovery of novel sirtuin activating compounds with prescribed effects on the binding in pockets near the active site interacting with flexible protein degrees of freedom around the active site. Novel kinetic models are used to confirm hit compounds and to improve their properties.

Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.

Abstract: A method and system for distributed messaging between a plurality of computer devices using a short range wireless communication protocol (SRWP) is disclosed. The communication protocol can be one in which slave devices provide data to master devices. A device automatically establishes master and slave connections with other devices via the protocol as they come into range. A user-entered message is displayed on the device and broadcast by the device over slave connections to other connected devices. Messages received by the device over its master connections are displayed and also rebroadcast to other connected devices. Messages can be displayed for a limited time period during which they fade or otherwise are altered to provide a visual indication of the display lifetime remaining for that message. A relay can be provided to receive an rebroadcast messages to connected devices and inject into the SRWP network from devices outside the network.

Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.

Abstract: A method and system for distributed messaging between a plurality of computer devices using a short range wireless communication protocol (SRWP) is disclosed. The communication protocol can be one in which slave devices provide data to master devices. A device automatically establishes master and slave connections with other devices via the protocol as they come into range. A user-entered message is displayed on the device and broadcast by the device over slave connections to other connected devices. Messages received by the device over its master connections are displayed and also rebroadcast to other connected devices. Messages can be displayed for a limited time period during which they fade or otherwise are altered to provide a visual indication of the display lifetime remaining for that message. A relay can be provided to receive an rebroadcast messages to connected devices and inject into the SRWP network from devices outside the network.

Abstract: A method and system for distributed messaging between a plurality of computer devices using a short range wireless communication protocol (SRWP) is disclosed. The communication protocol can be one in which slave devices provide data to master devices. A device automatically establishes master and slave connections with other devices via the protocol as they come into range. A user-entered message is displayed on the device and broadcast by the device over slave connections to other connected devices. Messages received by the device over its master connections are displayed and also rebroadcast to other connected devices. Messages can be displayed for a limited time period during which they fade or otherwise are altered to provide a visual indication of the display lifetime remaining for that message. A relay can be provided to receive an rebroadcast messages to connected devices and inject into the SRWP network from devices outside the network.

Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.

Abstract: A method and system for distributed messaging between a plurality of computer devices using a shortrange wireless communication protocol (SRWP) is disclosed. The communication protocol can be one in which slave devices provide data to master devices. A device automatically establishes master and slave connections with other devices via the protocol as they come into range. A user-entered message is displayed on the device and broadcast by the device over slave connections to other connected devices. Messages received by the device over its master connections are displayed and also rebroadcast to other connected devices. Messages can be displayed for a limited time period during which they fade or otherwise are altered to provide a visual indication of the display lifetime remaining for that message. A relay can be provided to receive an rebroadcast messages to connected devices and inject into the SRWP network from devices outside the network.