Abstract: An aerosol delivery system includes a perforate membrane including a plurality of apertures, as well as a fluid reservoir in fluid communication with a first side of the perforate membrane and actuation means configured to vibrate the perforate membrane to cause a liquid in the fluid reservoir during use to be ejected as liquid droplets from a second side of the perforate membrane. The plurality of apertures includes first and second arrays of apertures of first and second configurations which are grouped together in first and second discrete regions of the perforate membrane. The fluid reservoir includes first and second reservoir portions and a liquid barrier by which the first and second reservoir portions are separated. A removable cartridge for an aerosol delivery system.

Abstract: A cartridge for an aerosol delivery system. The cartridge includes a fluid reservoir including a first reservoir portion, a second reservoir portion, and at least one liquid barrier configured to separate the first and second reservoir portions. The first and second reservoir portions have respective first and second openings at a first end of the cartridge. The cartridge further includes a perforate membrane located at the first end of the cartridge and over the first and second openings. The first and second openings are configured to supply first and second liquids to a first side of the perforate membrane during use and the perforate membrane includes a plurality of apertures configured to eject one or both of the first and second liquids from a second side of the perforate membrane in the form of liquid droplets when the perforate membrane is vibrated. An aerosol delivery system includes the cartridge.

Abstract: A micro-nozzle with an integrated filter structure for receiving fluids at pressures between 0.1 MPa to 50 MPa, comprising: at least one fluid inlet, a fluid outlet comprising at least one orifice, a primary filter structure positioned downstream from the at least one fluid inlet and arranged to provide statistical filtration of fluid passing therethrough.

Abstract: A liquid droplet production apparatus comprising a perforate membrane and an actuator. The actuator is configured to vibrate the perforate membrane such that a liquid in contact with the perforate membrane during use is caused to pass through at least one aperture of the perforate membrane and to be ejected as liquid droplets from the perforate membrane. The perforate membrane includes one or more stiffening structures for increasing the stiffness of the perforate membrane, the one or more stiffening structures each being defined by a local transverse deformation of the perforate membrane. A removable cartridge, a perforate membrane, an actuator assembly for use in such a liquid droplet delivery apparatus, and a method of manufacturing a perforate membrane for such a liquid droplet apparatus.

Abstract: A system for delivering an agent to a patient, comprises a delivery device. The delivery device is configured to deliver a first agent to the patient, and comprises a reservoir, a transcutaneous delivery assembly, a pumping mechanism, a control module, a power supply, and a housing. The reservoir stores the first agent. The transcutaneous delivery assembly delivers the first agent to the patient transcutaneously. The pumping mechanism receives the first agent from the reservoir and propels the first agent to the transcutaneous delivery assembly. The control module controls at least the pumping mechanism. The power supply provides energy to at least the control module and the pumping mechanism. The housing surrounds at least the pumping mechanism. Methods of delivering an agent to the patient are also described.

Abstract: A liquid droplet production apparatus comprising a perforate membrane and an actuator. The actuator is configured to vibrate the perforate membrane such that a liquid in contact with the perforate membrane during use is caused to pass through at least one aperture of the perforate membrane and to be ejected as liquid droplets from the perforate membrane. The perforate membrane includes one or more stiffening structures for increasing the stiffness of the perforate membrane, the one or more stiffening structures each being defined by a local transverse deformation of the perforate membrane. A removable cartridge, a perforate membrane, an actuator assembly for use in such a liquid droplet delivery apparatus, and a method of manufacturing a perforate membrane for such a liquid droplet apparatus.

Abstract: A cartridge for an aerosol delivery system. The cartridge includes a fluid reservoir including a first reservoir portion, a second reservoir portion, and at least one liquid barrier configured to separate the first and second reservoir portions. The first and second reservoir portions have respective first and second openings at a first end of the cartridge. The cartridge further includes a perforate membrane located at the first end of the cartridge and over the first and second openings. The first and second openings are configured to supply first and second liquids to a first side of the perforate membrane during use and the perforate membrane comprises a plurality of apertures configured to eject one or both of the first and second liquids from a second side of the perforate membrane in the form of liquid droplets when the perforate membrane is vibrated. An aerosol delivery system includes the cartridge.

Abstract: A micro-nozzle with an integrated filter structure for receiving fluids at pressures between 0.1 MPa to 50 MPa, comprising: at least one fluid inlet, a fluid outlet comprising at least one orifice, a primary filter structure positioned downstream from the at least one fluid inlet and arranged to provide statistical filtration of fluid passing therethrough.

Abstract: An aerosol delivery system includes a perforate membrane comprising a plurality of apertures, as well as a fluid reservoir reservoir in fluid communication with a first side of the perforate membrane and actuation means configured to vibrate the perforate membrane to cause a liquid in the fluid reservoir during use to be ejected as liquid droplets from a second side of the perforate membrane. The plurality of apertures comprises first and second arrays of apertures of first and second configurations which are grouped together in first and second discrete regions of the perforate membrane. The fluid reservoir includes first and second reservoir portions and a liquid barrier by which the first and second reservoir portions are separated. A removable cartridge for an aerosol delivery system.

Abstract: A penile ring, a penile ring adapted for closing the urethra to prevent stress incontinence, having a ring-shaped body configured for surrounding a penis, the ring-shaped body comprising an upper part (10) including a backstop (20) extending in an arc around the upper part, and a lower part (30) including one or more expandable compression pads (40). The penile ring comprises a sensor (110) to detect urine flow in the urethra and to provide a signal that triggers the compression pads to expand inwards to occlude the urethra and thereby preventing flow of urine.