Abstract: Apparatus is provided for treating a vascular malformation, including an orifice section, an occlusion section, and a connecting section. When the apparatus is unconstrained, the orifice and occlusion sections are shaped so as to define orifice-section and occlusion-section curves that wind around non-coaxial orifice-section and occlusion-section central axes, respectively, at changing distances from the axes. The orifice-section curve defines an orifice-section central opening. A projection of the occlusion-section curve occludes at least 25% of a orifice-section-central-opening cross-sectional area of an orifice-section central opening; the projection of the occlusion-section curve is in a direction along the orifice-section central axis, onto an orifice-section plane perpendicular to the orifice-section central axis. Other embodiments are also described.

Abstract: An apparatus is provided for treating a vascular malformation. The apparatus includes an orifice section, an intra-vascular-malformation docking section, and a connecting section. The apparatus is configured such that, when unconstrained the orifice section is shaped so as to define an orifice-section curve that winds at least 2.5 turns around an orifice-section central axis at a changing distance from the orifice-section central axis, the intra-vascular-malformation docking section is shaped so as to define a docking-section curve that winds between 0.5 and 2 turns around a docking-section central axis at a changing or constant distance from the docking-section central axis, and the connecting section connects the orifice-section curve with the docking-section curve, and has an average radius of curvature that is different from an average radius of curvature of an outermost loop of the orifice-section curve. Other embodiments are also described.

Abstract: There is provided herein a non-occlusive blood restricting device for treating a vascular malformation, the blood restricting device consisting of a wire comprising a first section configured to be coiled into a first coil when deployed within the vascular malformation; wherein the first coil comprises a spiral or sequence of loops, the spiral or sequence of loops having a gradually decreasing diameter; and wherein the first coil is configured to line a neck and/or a wall of the vascular malformation so as to at least partially cover an orifice thereof, and a second section configured to be deployed within a blood vessel, adjacent the vascular malformation; wherein the second section is configured to form a second coil, circumferentially lining a wall of the blood vessel.

Abstract: A balloon catheter system comprising one or more conduits to which are attached a compliant balloon 84 having a non-helical shape in its deflated state, wherein said balloon is constructed such that is capable of adopting a spiral or helical conformation upon inflation, and wherein the external diameter of the spiral or helical balloon thus formed is in the range of 6-15 mm. The balloon catheter system of the present invention may be used for improving the perfusion of cardiac tissues in a mammalian subject, by means of inflating said balloon within the coronary sinus such that it adopts a spiral conformation, thereby causing partial occlusion of said coronary sinus and causing an elevation of coronary sinus pressure.

Abstract: A non-occlusive blood-restricting device is provided for treating a vascular malformation. The blood-restricting device includes a first section configured to assume a first shape when deployed from a microcatheter within a portion of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, the portion of the vascular malformation including one or more anatomical features selected from the group consisting of: a neck of the vascular malformation and a wall of the vascular malformation. The first shape defines a sequence of loops having a gradually decreasing diameter and coaxial around a first central axis. The blood-restricting device also includes a second section configured to assume a second shape when deployed from the microcatheter. The second shape defines a single loop around a second central axis when the blood-restricting device is not restrained. Other embodiments are also described.

Abstract: A delivery tool includes a tubular distal tip fixed to a distal end of a delivery tube. A retention portion of an implant wire of an implant is removably disposed within the tubular distal tip. A pull wire has a distal end portion that is shaped so as to define a pull-wire loop and is removably disposed partially within the delivery tube. A safety wire is removably disposed partially within the tubular distal tip, with a distal portion of the safety wire passing through a tip distal opening. The safety wire has a proximal end portion that is shaped so as to define a safety-wire hook hooked on the pull-wire loop. Proximal pulling on the pull wire proximally retracts the safety wire from the tip distal opening, thereby allowing the retention portion to pass through the tubular distal tip. Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. When deployed from a microcatheter within a wide-neck vascular aneurysm, the coilable section is configured to become coiled into a coil defining a sequence of concentric loops, and to bridge a neck of the aneurysm so as to at least partially cover an orifice of the aneurysm, when in use. The docking section is configured to be deployed from the microcatheter within the aneurysm. The docking section extends distally from an outermost one of the concentric loops of the coil, and is shaped so as to define one or more concentric loops having an outer diameter less than an outer diameter of the concentric loops of the coil. The docking section is configured to anchor, stabilize, and/or assist with positioning of the device within the aneurysm. Other embodiments are also described.

Abstract: Apparatus (720) is provided for treating a vascular malformation, including an orifice section (430), an occlusion section (432), and a connecting section (434). When the apparatus (720) is uncontrained, the orifice and occlusion sections (430, 432) are shaped so as to define orifice-section and occlusion-section curves (440, 450) that wind around non-coaxial orifice-section and occlusion-section central axes (442, 452), respectively, at changing distances from the axes (442, 452). The orifice-section curve (440) defines an orifice-section central opening (462). A projection of the occlusion-section curve (450) occludes at least 25% of a orifice-section-central-opening cross-sectional area of an orifice-section central opening (462); the projection of the occlusion-section curve (450) is in a direction along the orifice-section central axis (442), onto an orifice-section plane perpendicular to the orifice-section central axis (442). Other embodiments are also described.

Abstract: A delivery tool (22) includes a tubular distal tip (52) fixed to a distal end (54) of a delivery tube (50). A retention portion (38) of an implant wire (30) of an implant (20) is removably disposed within the tubular distal tip (52). A safety wire (60) is removably disposed partially within the tubular distal tip (52), with a distal portion (62) of the safety wire (60) passing through a tip distal opening (56). The safety wire (60) is shaped so as to define a helical portion (90), which, when unconstrained, has an unconstrained helical-portion outer diameter that is greater than a greatest inner diameter of the tubular distal tip (52). Proximal pulling on the safety wire (60) proximally retracts the safety wire (60) from the tip distal opening (56), thereby allowing the retention portion (38) to pass through the tubular distal tip (52). Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: A non-occlusive blood-restricting device is provided for treating a vascular malformation. The blood-restricting device includes a first section configured to assume a first shape when deployed from a microcatheter within a portion of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, the portion of the vascular malformation including one or more anatomical features selected from the group consisting of: a neck of the vascular malformation and a wall of the vascular malformation. The first shape defines a sequence of loops having a gradually decreasing diameter and coaxial around a first central axis. The blood-restricting device also includes a second section configured to assume a second shape when deployed from the microcatheter. The second shape defines a single loop around a second central axis when the blood-restricting device is not restrained. Other embodiments are also described.

Abstract: A non-occlusive blood-restricting device is provided for use with a microcatheter and for treating a vascular malformation. The device includes a first section, a second section, and an intermediate section. The first section is configured to assume a first shape when deployed from the microcatheter within a portion of the vascular malformation so as to at least partially cover an orifice of the vascular malformation. The first shape defines a sequence of loops having a gradually decreasing diameter. The second section is configured to assume a second shape when deployed from the microcatheter, wherein the second shape defines a sequence of one or more loops having a constant or gradually decreasing diameter. The intermediate section connects the first and the second sections and is configured to space apart the first and the second sections when deployed from the microcatheter. Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: There is provided herein a non-occlusive blood restricting device for treating a vascular malformation, the blood restricting device consisting of a wire comprising a first section configured to be coiled into a first coil when deployed within the vascular malformation; wherein the first coil comprises a spiral or sequence of loops, the spiral or sequence of loops having a gradually decreasing diameter; and wherein the first coil is configured to line a neck and/or a wall of the vascular malformation so as to at least partially cover an orifice thereof, and a second section configured to be deployed within a blood vessel, adjacent the vascular malformation; wherein the second section is configured to form a second coil, circumferentially lining a wall of the blood vessel.