Patents by Inventor Alon Shalev

Alon Shalev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11948295
    Abstract: Systems and methods for visualizing an unstained sperm cell are presented, the system comprises a data input utility that receives measured data comprising at least one quantitative phase microscopy image of the unstained sperm cell; a data processing utility comprising an image analyzer module that utilizes characteristic refractive index information of one or more organelles of the sperm cell, to process the at least one quantitative phase microscopy image and generate at least one corresponding gradient image that includes edge enhancement of the one or more organelles, and a virtual staining module that applies one or more predetermined virtual staining functions to the at least one quantitative phase microscopy image and at least one corresponding gradient image, thereby virtually stain at least one of the one or more organelles of the sperm cell and generate virtually stained image data of the sperm cell; and an output utility that utilizes the virtually stained image data of the sperm cell and generate
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: April 2, 2024
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Natan Tzvi Shaked, Alon Shalev, Yoav Nahum Nygate
  • Publication number: 20240050253
    Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).
    Type: Application
    Filed: October 23, 2023
    Publication date: February 15, 2024
    Applicant: ENDOSPAN LTD.
    Inventors: Yaniv MARMUR, Or ZIGELBOIM, Alon SHALEV
  • Patent number: 11813185
    Abstract: An endovascular system includes an elongate delivery shaft assembly, which, when a stent-graft is removably constrained in a radially-compressed delivery state along a distal end portion of the delivery shaft assembly, is shaped so as to define a self-orienting portion, which is shaped so as to define (a) at least proximal and distal curved portions, the proximal curved portion disposed more proximal than the distal curved portion, and (b) at least one point of inflection on a central longitudinal axis of the delivery shaft assembly longitudinally between the proximal and the distal curved portions. Upon positioning of a distal tip of the system near a bifurcation of a brachiocephalic artery from an aortic arch, the self-orienting portion automatically rotationally orients itself in the aortic arch to a rotational orientation in which an inferior lateral opening of the stent-graft faces upstream in the aortic arch. Other embodiments are also described.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: November 14, 2023
    Assignee: ENDOSPAN LTD.
    Inventors: Yaniv Marmur, Or Zigelboim, Alon Shalev
  • Publication number: 20220346987
    Abstract: A stent-graft (20) comprises strut members (30) and a graft member (32), which is fixed to the strut members (30). The strut members (30) and the graft member (32) are arranged so as to define, when the stent-graft (20) is in a radially-expanded state: a main tube (40), which is shaped so as to define a main lumen (42); and a lateral tube (50), which (a) has (i) a distal end (52) and (ii) a proximal end (54) that is joined to a lateral wall (56) of the main tube (40) at a junction (60), (b) is shaped so as to define a lateral lumen (62) that is in fluid communication with the main lumen (42), and (c) defines a central longitudinal axis (64). The strut members (30) that define the lateral tube (50) are shaped so as to define two to four non-contiguous arcuate members (70), which (a) are centered around the central longitudinal axis (64), and (b) collectively subtend at least 150 degrees around the central longitudinal axis (64).
    Type: Application
    Filed: July 13, 2022
    Publication date: November 3, 2022
    Applicant: ENDOSPAN LTD.
    Inventors: Yaniv MARMUR, Nir Shalom NAE, Alon SHALEV
  • Publication number: 20220304839
    Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).
    Type: Application
    Filed: June 15, 2022
    Publication date: September 29, 2022
    Applicant: ENDOSPAN LTD.
    Inventors: Yaniv MARMUR, Or ZIGELBOIM, Alon SHALEV
  • Patent number: 11419742
    Abstract: A stent-graft (20) comprises strut members (30) and a graft member (32), which is fixed to the strut members (30). The strut members (30) and the graft member (32) are arranged so as to define, when the stent-graft (20) is in a radially-expanded state: a main tube (40), which is shaped so as to define a main lumen (42); and a lateral tube (50), which (a) has (i) a distal end (52) and (ii) a proximal end (54) that is joined to a lateral wall (56) of the main tube (40) at a junction (60), (b) is shaped so as to define a lateral lumen (62) that is in fluid communication with the main lumen (42), and (c) defines a central longitudinal axis (64). The strut members (30) that define the lateral tube (50) are shaped so as to define two to four non-contiguous arcuate members (70), which (a) are centered around the central longitudinal axis (64); and (b) collectively subtend at least 150 degrees around the central longitudinal axis (64).
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: August 23, 2022
    Assignee: ENDOSPAN LTD.
    Inventors: Yaniv Marmur, Nir Shalom Nae, Alon Shalev
  • Patent number: 11389313
    Abstract: A method for treating a subject includes providing an endovascular system that includes a stent-graft and an elongate delivery shaft assembly. When the delivery shaft assembly is unconstrained and the stent-graft is removably constrained along a distal end portion of the delivery shaft assembly, the delivery shaft assembly is shaped so as to define a self-orienting portion, which is shaped so as to define at least proximal and distal curved portions. The delivery shaft assembly is transvascularly introduced into a descending aorta of the subject and a distal end of the delivery shaft assembly is advanced to an aortic arch, such that the self-orienting portion assumes a desired rotational orientation in the aortic arch. While the distal end of the delivery shaft assembly is positioned in the aortic arch, the stent-graft is released from the distal end portion of the delivery shaft assembly. Other embodiments are also described.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: July 19, 2022
    Assignee: ENDOSPAN LTD.
    Inventors: Yaniv Marmur, Or Zigelboim, Alon Shalev
  • Patent number: 11090148
    Abstract: Apparatus is provided for use with a delivery catheter, including a primary stent-graft and a flared endovascular stent-graft, which is configured to initially be positioned in the delivery catheter in a radially-compressed state, and to assume a radially-expanded state upon being deployed from the delivery catheter.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: August 17, 2021
    Assignee: ENDOSPAN LTD.
    Inventors: Alon Shalev, Raphael Benary
  • Publication number: 20210158521
    Abstract: Systems and methods for visualizing an unstained sperm cell are presented, the system comprises a data input utility that receives measured data comprising at least one quantitative phase microscopy image of the unstained sperm cell; a data processing utility comprising an image analyzer module that utilizes characteristic refractive index information of one or more organelles of the sperm cell, to process the at least one quantitative phase microscopy image and generate at least one corresponding gradient image that includes edge enhancement of the one or more organelles, and a virtual staining module that applies one or more predetermined virtual staining functions to the at least one quantitative phase microscopy image and at least one corresponding gradient image, thereby virtually stain at least one of the one or more organelles of the sperm cell and generate virtually stained image data of the sperm cell; and an output utility that utilizes the virtually stained image data of the sperm cell and generate
    Type: Application
    Filed: June 27, 2019
    Publication date: May 27, 2021
    Inventors: Natan Tzvi SHAKED, Alon SHALEV, Yoav Nahum NYGATE
  • Patent number: 10952884
    Abstract: An endovascular stent-graft is provided that includes a flexible stent member and a tubular fluid flow guide. The tubular fluid flow guide includes first and second fabrics. The first fabric includes a first biologically-compatible substantially blood-impervious material, and is attached to and covers the stent member along a first longitudinal portion of the stent-graft. The second fabric includes a second biologically-compatible substantially blood-impervious material different from the first material, and is attached to and covers the stent member along a second longitudinal portion of the stent-graft. The second longitudinal portion is at least partially non-longitudinally-overlapping with the first longitudinal portion. Other embodiments are also described.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 23, 2021
    Assignee: ENDOSPAN LTD.
    Inventor: Alon Shalev
  • Publication number: 20210077247
    Abstract: A multi-component stent-graft system (10) comprises first, second, and third generally tubular stent-grafts (20, 22, 24), which are configured to assume radially-expanded states. The first stent-graft (20) is shaped so as to define a first lateral opening (34) when in its radially-expanded state. The second stent-graft (22) is shaped so as to define a second lateral opening (44) when in its radially-expanded state. The first and second stent-grafts (20, 22) are configured such that the second stent-graft (22) forms a blood-impervious seal with the first stent-graft (20) around the first lateral opening (34) when the second stent-graft (22) is disposed therethrough, and the first and the second stent-grafts (20, 22) are in their radially-expanded states.
    Type: Application
    Filed: December 1, 2020
    Publication date: March 18, 2021
    Applicant: ENDOSPAN LTD.
    Inventors: Alon SHALEV, Sagi RAZ, Rafi BENARY
  • Patent number: 10929161
    Abstract: A method, computer program product, and system includes a processor(s) obtaining, during runtime, from a compiler, two versions of a data parallel loop for an operation. The host computing system comprises includes a CPU and a GPU is accessible to the host. The processor(s) online profiles the two versions by asynchronously executing the first version, in a profile mode, with the GPU and executing the second version, in the profile mode, with the CPU. The processor(s) generates execution times for the first version and the second version. The processor(s) stores the executions times and performance data in a storage, where the performance data comprises a size of the data parallel loop for the operation. The processor(s) update a regression model(s) to predict performance numbers for a process of an unknown loop size. The processor(s) execute the operation with the CPU or the GPU based on the performance data.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: February 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Gita Koblents, Alon Shalev Housfater, Kazuaki Ishizaki, Akihiro Hayashi
  • Publication number: 20210041336
    Abstract: Methods and systems for evaluating fertility potential of a living sperm cell are presented and involve providing a predetermined classification function correlating between one or more physio spatial parameters of sperm cells and DNA fragmentation distribution in sperm cells, providing data indicative of the one or more physio spatial parameters of the living sperm cell, and applying the classification function to the one or more physio spatial parameters of the living sperm cell to thereby determine a DNA fragmentation level, inside the DNA fragmentation distribution, in the living sperm cell, the DNA fragmentation level being indicative of the fertility potential of the living sperm cell.
    Type: Application
    Filed: January 30, 2019
    Publication date: February 11, 2021
    Inventors: ltay BARNEA, Natan Tzvi SHAKED, Lidor KARAKO, Michal BALBERG, Alon SHALEV
  • Patent number: 10905540
    Abstract: An endovascular prosthesis includes a stent-graft and an external coagulation inducer. The stent-graft includes a first portion of structural strut members and a first portion of a graft member, which, when the endovascular prosthesis is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer includes an extra-luminal skirt, which includes a second portion of the structural strut members and a second portion of the graft member, and is configured to assume: (i) when the endovascular prosthesis is removably disposed in a delivery sheath, a radially-compressed delivery state, in which the structural strut members of the first portion do not coincide with the structural stent members of the second portion, and (ii) when the endovascular prosthesis is unconstrained, a radially-expanded state, in which the extra-luminal skirt extends radially outward from an external surface of the stent-graft.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: February 2, 2021
    Assignee: ENDOSPAN LTD.
    Inventors: Or Zigelboim, Yaniv Marmur, Alon Shalev
  • Patent number: 10888413
    Abstract: A multi-component stent-graft system is provided, which includes a first stent-graft, which is configured to assume radially-expanded and radially-compressed states; and a second stent-graft, which is configured to assume radially-expanded and radially-compressed states. A delivery tool includes an outer tube, in which the first and the second stent-grafts are initially positioned at respective axial sites within the outer tube, in their radially-compressed states without being fixed to each other. Other embodiments are also described.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: January 12, 2021
    Assignee: ENDOSPAN LTD.
    Inventors: Alon Shalev, Sagi Raz, Rafi Benary
  • Publication number: 20200315825
    Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).
    Type: Application
    Filed: June 23, 2020
    Publication date: October 8, 2020
    Applicant: ENDOSPAN LTD.
    Inventors: Yaniv MARMUR, Or ZIGELBOIM, Alon SHALEV
  • Publication number: 20200107925
    Abstract: An endovascular stent-graft (10, 110, 210, 310) is provided that includes elastic struts (20) and a fluid flow guide (30) that is fixed to first and second subsets (32, 34) of the struts (20). The struts (20) of the first subset (32) are arranged as circumferential cells (80) in circumferentially-continuous rings (56), which cause the fluid flow guide (30) to define substantially cylindrical tubular portions (40). The struts (20) of the second subset (34) cause the fluid flow guide (30) to define a bulge (42) having a greatest bulge radius from a central longitudinal axis (38) that is at least 5% greater than an average radius of the substantially cylindrical tubular portions (40) proximally and distally adjacent the bulge (42). The struts (20) of the second subset (34) define tip portions (50).
    Type: Application
    Filed: March 21, 2018
    Publication date: April 9, 2020
    Applicant: ENDOSPAN LTD.
    Inventors: Or ZIGELBOIM, Yaniv MARMUR, Alon SHALEV
  • Publication number: 20200069445
    Abstract: A stent-graft (20) comprises strut members (30) and a graft member (32), which is fixed to the strut members (30). The strut members (30) and the graft member (32) are arranged so as to define, when the stent-graft (20) is in a radially-expanded state: a main tube (40), which is shaped so as to define a main lumen (42); and a lateral tube (50), which (a) has (i) a distal end (52) and (ii) a proximal end (54) that is joined to a lateral wall (56) of the main tube (40) at a junction (60), (b) is shaped so as to define a lateral lumen (62) that is in fluid communication with the main lumen (42), and (c) defines a central longitudinal axis (64). The strut members (30) that define the lateral tube (50) are shaped so as to define two to four non-contiguous arcuate members (70), which (a) are centered around the central longitudinal axis (64); and (b) collectively subtend at least 150 degrees around the central longitudinal axis (64).
    Type: Application
    Filed: October 30, 2019
    Publication date: March 5, 2020
    Applicant: ENDOSPAN LTD.
    Inventors: Yaniv MARMUR, Nir Shalom NAE, Alon SHALEV
  • Patent number: 10540194
    Abstract: A method, computer program product, and system includes a processor(s) obtaining, during runtime, from a compiler, two versions of a data parallel loop for an operation. The host computing system comprises includes a CPU and a GPU is accessible to the host. The processor(s) online profiles the two versions by asynchronously executing the first version, in a profile mode, with the GPU and executing the second version, in the profile mode, with the CPU. The processor(s) generates execution times for the first version and the second version. The processor(s) stores the executions times and performance data in a storage, where the performance data comprises a size of the data parallel loop for the operation. The processor(s) update a regression model(s) to predict performance numbers for a process of an unknown loop size. The processor(s) execute the operation with the CPU or the GPU based on the performance data.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: January 21, 2020
    Assignee: International Business Machines Corporation
    Inventors: Gita Koblents, Alon Shalev Housfater, Kazuaki Ishizaki, Akihiro Hayashi
  • Publication number: 20190384623
    Abstract: A method, computer program product, and system includes a processor(s) obtaining, during runtime, from a compiler, two versions of a data parallel loop for an operation. The host computing system comprises includes a CPU and a GPU is accessible to the host. The processor(s) online profiles the two versions by asynchronously executing the first version, in a profile mode, with the GPU and executing the second version, in the profile mode, with the CPU. The processor(s) generates execution times for the first version and the second version. The processor(s) stores the executions times and performance data in a storage, where the performance data comprises a size of the data parallel loop for the operation. The processor(s) update a regression model(s) to predict performance numbers for a process of an unknown loop size. The processor(s) execute the operation with the CPU or the GPU based on the performance data.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 19, 2019
    Inventors: Gita Koblents, Alon Shalev Housfater, Kazuaki Ishizaki, Akihiro Hayashi