Patents by Inventor Aloysius Nchinda

Aloysius Nchinda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Angiotensin I-converting enzyme (ACE) inhibitors
    Patent number: 7981922
    Abstract: This invention relates to a process for synthesizing an amino acid derivative of a tripeptidomimetic, such as lisinopril. The invention also relates to a derivative of lisinopril, incorporating a amino acid moeity such as tryptophan at the P2? position.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: July 19, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-converting enzyme (ACE) inhibitors
    Patent number: 7951834
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: May 31, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-converting enzyme (ace) inhibitors
    Publication number: 20090281160
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Application
    Filed: May 29, 2006
    Publication date: November 12, 2009
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-Converting Enzyme (ACE) Inhibitors
    Publication number: 20090118351
    Abstract: This invention relates to a process for synthesising an amino acid derivative of a tripeptidomimetic, such as lisinopril. The invention also relates to a derivative of lisinopril, incorporating a amino acid moeity such as tryptophan at the P2? position.
    Type: Application
    Filed: May 29, 2006
    Publication date: May 7, 2009
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale