Patents by Inventor Alphonse Peter Granatek

Alphonse Peter Granatek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aqueous suspensions of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido]-3-(1,2,3-triazol -5-ylthiomethyl)-3-cephem-4-carboxylic acid 1,2-propylene glycolate
    Patent number: 4034089
    Abstract: The antibacterial agent 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid, which is a zwitterion, is both purified and converted to a form highly suitable for use in aqueous suspensions by converting it to the crystalline 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid 1,2-propylene glycolate, said propylene glycolate containing 1.0 - 1.6 moles of 1,2-propylene glycol per mole of cephalosporin zwitterion.
    Type: Grant
    Filed: March 5, 1976
    Date of Patent: July 5, 1977
    Assignee: Bristol-Myers Company
    Inventors: Murray Arthur Kaplan, Alphonse Peter Granatek
  • Injectable formulations of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol- 5-ylthiomethyl)-3-cephem-4-carboxylic acid
    Patent number: 4001409
    Abstract: Antibacterial compositions comprising 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid in the form of a hydrate or a hydrochloride salt and a sodium, potassium or calcium salt of levulinic acid have been found to be stable, useful, water-soluble forms of the cephalosporin antibiotic especially advantageous for parenteral administration.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: January 4, 1977
    Assignee: Bristol-Myers Company
    Inventors: Alphonse Peter Granatek, Murray Arthur Kaplan
  • Crystalline sesquihydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol- 5-ylthiomethyl)-3-cephem-4-carboxylic acid
    Patent number: 3985747
    Abstract: The crystalline sesquihydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid is prepared and found to be a stable useful form of the cephalosporin antibiotic particularly advantageous for pharmaceutical formulations.
    Type: Grant
    Filed: May 24, 1974
    Date of Patent: October 12, 1976
    Assignee: Bristol-Myers Company
    Inventors: Murray Arthur Kaplan, Alphonse Peter Granatek
  • Crystalline cephalosporin derivative
    Patent number: 3970651
    Abstract: The antibacterial agent 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid, which is a zwitterion, is both purified and converted to a form highly suitable for use in aqueous suspensions by converting it to the crystalline 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid 1,2-propylene glycolate, said propylene glycolate containing 1.0 - 1.6 moles of 1,2-propylene glycol per mole of cephalosporin zwitterion.
    Type: Grant
    Filed: December 18, 1974
    Date of Patent: July 20, 1976
    Assignee: Bristol-Myers Company
    Inventors: Murray Arthur Kaplan, Alphonse Peter Granatek