Abstract: Optimization systems and methods for optimizing business operations and asset systems are disclosed. A system includes digital twins corresponding to asset systems; business models corresponding to business operations; and an electronic control unit (ECU). The ECU is programmed to: implement an asset optimizer module, where implementing the asset optimizer module interconnects the digital twins for optimization; execute the asset optimizer module, where the asset optimizer module optimizes the digital twins to obtain one or more optimization parameters for the asset systems; implement a system optimizer module, where the system optimizer module receives the one or more optimization parameters and the business models; execute the system optimizer module, where the system optimizer module generates operation protocols for the business models; and output, to a user, the operation protocols for implementation in a real-world asset system.