Abstract: In some embodiments, the present disclosure relates to a method for generating a prognosis. The method may be performed by providing one or more digitized biopsy images of a patient having a glioma. One or more necrotic regions and one or more non-necrotic regions are identified within the one or more digitized biopsy images using a first deep learning algorithm. A second deep learning algorithm is applied to the one or more non-necrotic regions to identify glioblastoma multiforme (GBM) histopathological indicators within the one or more non-necrotic regions.

Abstract: The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

Abstract: The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

Abstract: The invention is related to an electronic assembly comprising a printed circuit board and an electronic component. The printed circuit board comprises a first side and a second side opposite to the first side. The electronic component is installed in the first side of the printed circuit board. The printed circuit board is an insulated metal substrate printed circuit board and comprises a bending portion which divides the printed circuit board into a first main portion and a second main portion, the electronic component being located in the first main portion. The first and second main portions are not comprised in a common plane.

Abstract: A cooling device for cooling a light source located in an automotive luminous device. This cooling device includes a heat sink intended to be in thermal contact with the light source, a plurality of fins in direct thermal contact with the heat sink, a plurality of pins in direct thermal contact with the heat sink and a fan. The fan is arranged to make a fluid flow from an inlet of the cooling device to an outlet to the cooling device, so that the plurality of fins are nearer the inlet than the plurality of pins.

Abstract: The invention is related to an electronic assembly comprising a printed circuit board and an electronic component. The printed circuit board comprises a first side and a second side opposite to the first side. The electronic component is installed in the first side of the printed circuit board. The printed circuit board is an insulated metal substrate printed circuit board and comprises a bending portion which divides the printed circuit board into a first main portion and a second main portion, the electronic component being located in the first main portion. The first and second main portions are not comprised in a common plane.

Abstract: A cooling device for cooling a light source located in an automotive luminous device. This cooling device includes a heat sink intended to be in thermal contact with the light source, a plurality of fins in direct thermal contact with the heat sink, a plurality of pins in direct thermal contact with the heat sink and a fan. The fan is arranged to make a fluid flow from an inlet of the cooling device to an outlet to the cooling device, so that the plurality of fins are nearer the inlet than the plurality of pins.

Abstract: A nozzle including a coupling portion, intended to be coupled to at least two hot gas outlets of a welding tool, and a transition portion, connected to the coupling portion. The transition portion has a first width in the connection between the transition portion and the coupling portion, and has a second width in an end opposite to the connection between the transition portion and the coupling portion, the second width being greater than the first width.

Abstract: A method for determining the 3D location and orientation of a fiducial reference comprises disposing the fiducial reference so as to render a part of the fiducial reference observable by a tracker; obtaining from the tracker scan data of the part of the fiducial reference that is observable by the tracker; obtaining predetermined geometric information about location points on the fiducial reference, the geometric information containing three-dimensional coordinates of the location points relative to the structure of the fiducial reference; identifying within the scan data at least three location points having coordinates in the predetermined geometric information; and determining from the scan data and the coordinates of the three identified location points in the predetermined geometric information the 3D location and orientation of the fiducial reference.

Abstract: A valve assembly includes a valve base having a tubular section with a longitudinal bore formed therein, a fluid inlet port and a common port with an internal passageway therebetween. A solenoid coil is adapted to generate a magnetic flux and includes a longitudinal axis and a bore coaxial therewith. The valve assembly further includes an orifice piece positioned within the longitudinal bore of the valve base. The orifice piece includes a central passageway with a first end and a second end. A plunger is movable within the longitudinal bore between a first de-actuated position and a second actuated position.

Abstract: A method for determining the 3D location and orientation of a fiducial reference comprises disposing the fiducial reference so as to render a part of the fiducial reference observable by a tracker; obtaining from the tracker scan data of the part of the fiducial reference that is observable by the tracker; obtaining predetermined geometric information about location points on the fiducial reference, the geometric information containing three-dimensional coordinates of the location points relative to the structure of the fiducial reference; identifying within the scan data at least three location points having coordinates in the predetermined geometric information; and determining from the scan data and the coordinates of the three identified location points in the predetermined geometric information the 3D location and orientation of the fiducial reference.

Abstract: A valve assembly includes a valve base having a tubular section with a longitudinal bore formed therein, a fluid inlet port and a common port with an internal passageway therebetween. A solenoid coil is adapted to generate a magnetic flux and includes a longitudinal axis and a bore coaxial therewith. The valve assembly further includes an orifice piece positioned within the longitudinal bore of the valve base. The orifice piece includes a central passageway with a first end and a second end. A plunger is movable within the longitudinal bore between a first de-actuated position and a second actuated position.

Abstract: A high-speed railway aerodynamic sleeper (1) including one central area (2), two support areas (3) on each side of the central area (2), on which the rails are placed, and two outer areas (4), located at the ends of the sleeper (1), following the support areas (3). The cross-section of the sleeper (1) includes, on the central area (2), and the support areas (3), and the two outer areas (4), a first bottom section (5) comprising a first polygon (7) having at least 4 sides and a second top section (6) having at least one second polygon (8) of n sides, n being?4, the first bottom section (5) and the second top section (6) being attached to each other, and the top base (10) of the first polygon (7) and the bottom base (9) of the second polygon (8) share their sides.

Abstract: A method for determining the 3D location and orientation of a fiducial reference comprises disposing the fiducial reference so as to render a part of the fiducial reference observable by a tracker; obtaining from the tracker scan data of the part of the fiducial reference that is observable by the tracker; obtaining predetermined geometric information about location points on the fiducial reference, the geometric information containing three-dimensional coordinates of the location points relative to the structure of the fiducial reference; identifying within the scan data at least three location points having coordinates in the predetermined geometric information; and determining from the scan data and the coordinates of the three identified location points in the predetermined geometric information the 3D location and orientation of the fiducial reference.

Abstract: The high-speed railway aerodynamic sleeper (1) comprises one central area (2), two support areas (3) on each side of the central area (2), on which the rails are placed, and two outer areas (4), located at the ends of the sleeper (1), following the support areas (3). The cross-section of the sleeper (1) comprises, on the central area (2), and the support areas (3), and the two outer areas (4), a first bottom section (5) comprising a first polygon (7) of at least 4 sides and a second top section (6) comprising at least one second polygon (8) of n sides, n being ?4, the first bottom section (5) and the second top section (6) being attached to each other, and the top base (10) of the first polygon (7) and the bottom base (9) of the second polygon (8) share their sides.