Abstract: This invention consists of a new analyzer system of the sounds generated in mills that capture the signals issued by the mineral and steel balls cascade that perform grinding. These signals are processed in an embedded system (2) formed by a field programmable gates array (FPGA) and a processor. The system is comprised of an industrial microphone array (1) that captures the sound signals that are converted from analog to digital through and acquisition system (3) specialized in sound signals, processed by a FPGA capable of performing parallel operations at high speed due to the customized hardware developed for this application, and sent to the processor through a high-speed data bus.

Abstract: A modular fluid-dosing system includes at least one hosting structure, a logic module and several dosing modules set up to add one or more fluids in one or more dosing points during a process, where an exact amount of a substance is necessary, using a manifold system. One of the dosing modules may be a dedicated module, specifically designed to add one reagent within one dosing point. Additionally, one of the dosing modules may be a multiplexor module, which permits the adding of the same fluid along several dosing points in a sequential manner. This is a flexible system that can have different configurations, combining dedicated and multiplexor modules that are required according to the needs of the process. Dosing modules are installed on support devices that permit reconfiguring the system structure according to the needs of the dosing process without affecting the internal design of the distribution system.

Abstract: This invention consists of a new analyzer system of the sounds generated in mills that capture the signals issued by the mineral and steel balls cascade that perform grinding. These signals are processed in an embedded system (2) formed by a field programmable gates array (FPGA) and a processor. The system is comprised of an industrial microphone array (1) that captures the sound signals that are converted from analog to digital through and acquisition system (3) specialized in sound signals, processed by a FPGA capable of performing parallel operations at high speed due to the customized hardware developed for this application, and sent to the processor through a high-speed data bus.

Abstract: Provided herein are methods for expressing a polynucleotide of interest in the retina of a subject. In particular, a method for expressing a polynucleotide of interest in the retina of a subject comprising the step consisting of injecting into the vitreous an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of Dp71 expression is provided.

Abstract: The present invention relates to methods for expressing a polynucleotide of interest in the retina of a subject. In particular, the present invention relates to a method for expressing a polynucleotide of interest in the retina of a subject comprising the step consisting of injecting into the vitreous an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of Dp71 expression.

Abstract: The present invention relates to a non human animal model for increased retinal vascular permeability wherein said increased retinal vascular permeability is induced by inhibiting in Müller cells of said animal the expression of a gene encoding for Dp71 or a dystrophin associated protein (DAP). Furthermore, the present invention relates to methods and compositions for the treatment of a disease associated with an increased retinal vascular permeability in a subject in need thereof.

Abstract: The present invention relates to methods and compositions for inhibiting or stimulating angiogenesis. The invention shows the implication of Dp71 in angiogenesis and thus provides novel therapeutic approaches, as well as novel methods for screening agents modulating angiogenesis, which target this protein. More specifically, the present invention relates to the use of Dp71 or a variant thereof (or a coding nucleic acid) for stimulating angiogenesis in a subject, particularly a human subject. The invention relates to the use of an inhibitor of Dp71 for inhibiting angiogenesis in a subject.

Abstract: The present invention relates to a non human animal model for increased retinal vascular permeability wherein said increased retinal vascular permeability is induced by inhibiting in Müller cells of said animal the expression of a gene encoding for Dp71 or a dystrophin associated protein (DAP). Furthermore, the present invention relates to methods and compositions for the treatment of a disease associated with an increased retinal vascular permeability in a subject in need thereof.

Abstract: The present invention relates to methods and compositions for inhibiting or stimulating angiogenesis. The invention shows the implication of Dp71 in angiogenesis and thus provides novel therapeutic approaches, as well as novel methods for screening agents modulating angiogenesis, which target this protein. More specifically, the present invention relates to the use of Dp71 or a variant thereof (or a coding nucleic acid) for stimulating angiogenesis in a subject, particularly a human subject. The invention relates to the use of an inhibitor of Dp71 for inhibiting angiogenesis in a subject.