Abstract: Systems and methods are disclosed for predicting a functional impairment status. A method for predicting a functional impairment status comprises administering a battery of assessments to a patient, and receiving a plurality of response thereto; collecting performance parameters based on the patient's performance on the battery of assessments; providing the collected performance parameters and the plurality of responses to a pretrained machine learning model; predicting, using the pretrained machine learning model, a likelihood of the patient having an impairment in daily activity; determining a functional impairment status of the patient based on the prediction, and outputting the functional impairment status.