Abstract: A portable multi-sensor device (1) comprises a substantially sheet-like and at least partially flexible unit support element (2), a garment (W) designed to be worn by a user and to be removably associated with the unit element (2), a plurality of sensors (S), adapted to detect biological and/or vital parameters on the body of a user and transduce them into electric signals, at least one of which is incorporated in the unit support element (2), transceiver means (6) for remote transmission of the electric signals to a remote monitoring center (C), processing and control means (6?) for processing and controlling the associated electric signals, therapeutic treatment means (21) associated with the unit support element (2) and designed to contact one part of the wearer's body.