Patents by Inventor Alyce Linthurst Jones
Alyce Linthurst Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11395725Abstract: The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.Type: GrantFiled: September 19, 2018Date of Patent: July 26, 2022Assignee: LifeNet HealthInventors: Alyce Linthurst Jones, Jason B. Schulte, Eric Moore, Perry L. Lange, Rex Nagao
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Publication number: 20220202556Abstract: The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.Type: ApplicationFiled: March 15, 2022Publication date: June 30, 2022Applicant: LifeNet HealthInventors: Alyce Linthurst Jones, Jason B. Schulte, Eric Moore, Perry L. Lange, Rex Nagao
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Publication number: 20210330444Abstract: The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.Type: ApplicationFiled: September 19, 2018Publication date: October 28, 2021Applicant: LifeNet HealthInventors: Alyce Linthurst JONES, Jason B. SCHULTE, Eric MOORE, Perry L. LANGE, Rex NAGAO
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Publication number: 20190001022Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.Type: ApplicationFiled: September 10, 2018Publication date: January 3, 2019Applicant: LIFENET HEALTHInventors: Lloyd Wolfinbarger, JR., Perry Lange, Alyce Linthurst-Jones, Eric Moore, Barry Nolf
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Patent number: 9936688Abstract: The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and/or reproductively non-viable cells, and preferably retains large molecular weight cytoplasmic proteins, such implants produced both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. A devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, optionally followed by inducing a pressure mediated flow of a salt solution, then washing the tissue to produce the devitalized graft. The devitalized grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple devitalized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes.Type: GrantFiled: October 19, 2013Date of Patent: April 10, 2018Assignee: LifeNet HealthInventors: Lloyd Wolfinbarger, Jr., Perry Lange, Alyce Linthurst-Jones, Eric Moore, Barry Nolf
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Patent number: 9408875Abstract: Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the inventive tissue repair compositions contain a radioprotectant. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. Kits for using such tissue repair compositions are also provided.Type: GrantFiled: March 16, 2015Date of Patent: August 9, 2016Assignee: LifeNet HealthInventors: Leila Masinaei, Lloyd Wolfinbarger, Jr., Silvia S. Chen, Alyce Linthurst Jones, Jingsong Chen
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Publication number: 20160008514Abstract: The invention relates to a soft tissue pouch and methods of use thereof.Type: ApplicationFiled: March 17, 2014Publication date: January 14, 2016Applicant: LifeNet HealthInventor: Alyce Linthurst JONES
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Patent number: 9125743Abstract: The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps.Type: GrantFiled: July 16, 2007Date of Patent: September 8, 2015Assignee: LifeNet HealthInventors: Silvia Sihui Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, Mark Moore, Rony Thomas, Alyce Linthurst Jones
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Publication number: 20150182559Abstract: Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the inventive tissue repair compositions contain a radioprotectant. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. Kits for using such tissue repair compositions are also provided.Type: ApplicationFiled: March 16, 2015Publication date: July 2, 2015Applicant: LifeNet HealthInventors: Leila Masinaei, Lloyd Wolfinbarger, JR., Silvia S. Chen, Alyce Linthurst Jones, Jingsong Chen
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Patent number: 9005646Abstract: Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the inventive tissue repair compositions contain a radioprotectant. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. Kits for using such tissue repair compositions are also provided.Type: GrantFiled: March 26, 2010Date of Patent: April 14, 2015Assignee: LifeNet HealthInventors: Leila Masinaei, Lloyd Wolfinbarger, Jr., Silvia S. Chen, Alyce Linthurst Jones, Jingsong Chen
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Publication number: 20140154663Abstract: The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and/or reproductively non-viable cells, and preferably retains large molecular weight cytoplasmic proteins, such implants produced both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. A devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, optionally followed by inducing a pressure mediated flow of a salt solution, then washing the tissue to produce the devitalized graft. The devitalized grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple devitalized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes.Type: ApplicationFiled: October 19, 2013Publication date: June 5, 2014Applicant: LifeNet HealthInventors: Lloyd Wolfinbarger, Perry Lange, Alyce Linthurst-Jones, Eric Moore, Barry Nolf
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Publication number: 20140065238Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-tem durability and function.Type: ApplicationFiled: October 31, 2013Publication date: March 6, 2014Applicant: LifeNet HealthInventors: Lloyd Wolfinbarger, JR., Peny Lange, Alyce Linthurst-Jones, Eric Moore, Barry Naif
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Patent number: 8574826Abstract: The invention provides methodologies and apparatus for producing a cellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.Type: GrantFiled: October 8, 2010Date of Patent: November 5, 2013Assignee: LifeNet HealthInventors: Lloyd Wolfinbarger, Jr., Perry Lange, Alyce Linthurst Jones, Eric Moore, Barry Nolf
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Patent number: 8563232Abstract: The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and/or reproductively non-viable cells, and preferably retains large molecular weight cytoplasmic proteins, such implants produced both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. A devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, optionally followed by inducing a pressure mediated flow of a salt solution, then washing the tissue to produce the devitalized graft. The devitalized grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple devitalized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes.Type: GrantFiled: October 28, 2003Date of Patent: October 22, 2013Assignee: LifeNet HealthInventors: Lloyd Wolfinbarger, Jr., Perry Lange, Alyce Linthurst-Jones, Eric Moore, Barry Nolf
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Publication number: 20110143438Abstract: The invention provides methodologies and apparatus for producing a cellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.Type: ApplicationFiled: October 8, 2010Publication date: June 16, 2011Inventors: Lloyd Wolfinbarger, JR., Perry Lange, Alyce Linthurst Jones, Eric Moore, Barry Nolf
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Publication number: 20110045044Abstract: Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the inventive tissue repair compositions contain a radioprotectant. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. Kits for using such tissue repair compositions are also provided.Type: ApplicationFiled: March 26, 2010Publication date: February 24, 2011Applicant: LifeNet HealthInventors: Leila Masinaei, Lloyd Wolfinbarger, JR., Silvia S. Chen, Alyce Linthurst Jones, Jingsong Chen
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Publication number: 20090041729Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.Type: ApplicationFiled: March 3, 2008Publication date: February 12, 2009Applicant: LifeNet HealthInventors: Lloyd Wolfinbarger, JR., Perry Lange, Alyce Linthurst Jones, Eric Moore, Barry Nolf
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Publication number: 20090024229Abstract: The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps.Type: ApplicationFiled: July 16, 2007Publication date: January 22, 2009Inventors: Silvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR., Mark Moore, Rony Thomas, Alyce Linthurst Jones