Patents by Inventor Alyse Portnoff

Alyse Portnoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED PROTEIN SILENCING USING CHIMERAS BETWEEN ANTIBODIES AND UBIQUITINATION ENZYMES
    Publication number: 20220348644
    Abstract: The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immunospecifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers.
    Type: Application
    Filed: November 23, 2021
    Publication date: November 3, 2022
    Inventors: Matthew DELISA, Jeffrey VARNER, Alyse PORTNOFF
  • Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes
    Patent number: 11192942
    Abstract: The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immunospecifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: December 7, 2021
    Assignee: Cornell University
    Inventors: Matthew DeLisa, Jeffrey Varner, Alyse Portnoff
  • TARGETED PROTEIN SILENCING USING CHIMERAS BETWEEN ANTIBODIES AND UBIQUITINATION ENZYMES
    Publication number: 20190233507
    Abstract: The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immunospecifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers.
    Type: Application
    Filed: April 9, 2019
    Publication date: August 1, 2019
    Inventors: Matthew DeLisa, Jeffrey Varner, Alyse Portnoff
  • TARGETED PROTEIN SILENCING USING CHIMERAS BETWEEN ANTIBODIES AND UBIQUITINATION ENZYMES
    Publication number: 20140112922
    Abstract: The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immuno specifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers.
    Type: Application
    Filed: March 28, 2012
    Publication date: April 24, 2014
    Applicant: CORNELL UNIVERSITY
    Inventors: Matthew Delisa, Jeffrey Varner, Alyse Portnoff