Patents by Inventor Alyson Smith

Alyson Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaryl trehalose compounds and uses thereof
    Patent number: 12319709
    Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Grant
    Filed: February 9, 2024
    Date of Patent: June 3, 2025
    Assignee: University of Montana
    Inventors: David Burkhart, George Ettenger, Jay Evans, Kendal T. Ryter, Alyson Smith
  • IMMUNOSTIMULATORY COMPOUNDS AND CONJUGATES
    Publication number: 20250090875
    Abstract: The present disclosure provides, inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer. The antibody drug conjugates can be configured to elicit tumor site-specific responses, including tumor microenvironment immunostimulation, while limiting off-target and systemic effects. In certain embodiments disclosed herein, the antibody drug conjugates are configured to release payloads following internalization by immune, cancer, or tumor associated cells.
    Type: Application
    Filed: July 31, 2023
    Publication date: March 20, 2025
    Inventors: Kung-Pern WANG, Alyson SMITH, Christopher Scott NEUMANN, Shyra J. GARDAI, David FERGUSON
  • DIARYL TREHALOSE COMPOUNDS AND USES THEREOF
    Publication number: 20240309037
    Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Application
    Filed: February 9, 2024
    Publication date: September 19, 2024
    Inventors: David Burkhart, George Ettenger, Jay Evans, Kendal T. Ryter, Alyson Smith
  • Immunigenic alpha-branched trehalose-diesters
    Patent number: 12064480
    Abstract: The invention relates to compounds of formula (I) and their use in eliciting a pro-Thl7 immune response. Further provided are methods of production of said compounds. (Formula I) wherein m is an integer between 4 and 13; n is an integer between 4 and 13; x is an integer between 4 and 13; y is an integer between 4 and 13.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: August 20, 2024
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Jay T Evans, Alyson Smith
  • IMMUNOSTIMULATORY COMPOUNDS AND CONJUGATES
    Publication number: 20240165251
    Abstract: The present disclosure provides, inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer. The antibody drug conjugates can be configured to elicit tumor site-specific responses, including tumor microenvironment immunostimulation, while limiting off-target and systemic effects. In certain embodiments disclosed herein, the antibody drug conjugates are configured to release payloads following internalization by immune, cancer, or tumor associated cells.
    Type: Application
    Filed: July 31, 2023
    Publication date: May 23, 2024
    Inventors: Kung-Pern WANG, Alyson SMITH, Christopher Scott NEUMANN, Shyra J. GARDAI, David FERGUSON
  • Diaryl trehalose compounds and uses thereof
    Patent number: 11912736
    Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: February 27, 2024
    Assignee: THE UNIVERSITY OF MONTANA
    Inventors: David Burkhart, George Ettenger, Jay Evans, Kendal T. Ryter, Alyson Smith
  • Methods of Treating Cancer with Anti-TIGIT Antibodies
    Publication number: 20240025998
    Abstract: Provided herein are methods of treating cancer with an anti-TIGIT antibody in combination with an anti-PD-1 antibody and/or an anti-PD-L1 antibody.
    Type: Application
    Filed: September 29, 2023
    Publication date: January 25, 2024
    Applicant: Seagen Inc.
    Inventors: Shyra Gardai, Alyson Smith
  • Combination Therapy
    Publication number: 20230270877
    Abstract: Provided herein are methods of treating cancer with an antibody that binds an immune cell engager in combination with an antibody-drug conjugate.
    Type: Application
    Filed: April 28, 2023
    Publication date: August 31, 2023
    Applicant: Seagen Inc.
    Inventors: Shyra Gardai, Alyson Smith, Kerry Klussman, Bernard Liu, Heather Van Epps
  • Immunogenic trehalose compounds and uses thereof
    Patent number: 11572381
    Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 7, 2023
    Assignee: The University of Montana
    Inventors: David Burkhart, Jay Evans, Craig Johnson, Kendal T. Ryter, Alyson Smith, Walid Abdelwahab Marzouky Abdelwahab
  • DIARYL TREHALOSE COMPOUNDS AND USES THEREOF
    Publication number: 20210139521
    Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Application
    Filed: February 21, 2019
    Publication date: May 13, 2021
    Inventors: David Burkhart, George Ettenger, Jay Evans, Kendal T. Ryter, Alyson Smith
  • IMMUNIGENIC ALPHA-BRANCHED TREHALOSE-DIESTERS
    Publication number: 20210077618
    Abstract: The invention relates to compounds of formula (I) and their use in eliciting a pro-Thl7 immune response. Further provided are methods of production of said compounds. (Formula I) wherein m is an integer between 4 and 13; n is an integer between 4 and 13; x is an integer between 4 and 13; y is an integer between 4 and 13.
    Type: Application
    Filed: April 12, 2019
    Publication date: March 18, 2021
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Jay T EVANS, Alyson SMITH
  • IMMUNOGENIC TREHALOSE COMPOUNDS AND USES THEREOF
    Publication number: 20200369704
    Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Application
    Filed: March 1, 2019
    Publication date: November 26, 2020
    Inventors: David Burkhart, Jay Evans, Craig Johnson, Kendal T. Ryter, Alyson Smith, Walid Abdelwahab Marzouky Abdelwahab