Patents by Inventor Alyssa Miller

Alyssa Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO DERIVATION OF GONADAL SOMATIC CELLS
    Publication number: 20250084372
    Abstract: Provided herein are methods of generating gonadal cell populations such as ovarian somatic cells from pluripotent stem cells. Also included are gonadal cell populations, as well as intermediate cell populations generated therein.
    Type: Application
    Filed: November 1, 2021
    Publication date: March 13, 2025
    Applicant: Conception Biosciences, Inc.
    Inventors: Rhishikesh BARGAJE, Karmen Seres, Pablo Hurtado-Gonzalez, Alyssa Miller
  • Compositions and methods for obtaining 3-dimensional lung-like epithelium and related uses thereof
    Patent number: 11857697
    Abstract: The invention disclosed herein generally relates to methods and systems for growing, expanding and/or obtaining 3-dimensional lung-like epithelium comprising cells having SOX9 protein activity and SOX2+ protein activity. In particular, the invention disclosed herein relates to methods and systems for growing human cells having SOX9 protein activity and SOX2+ protein activity in vitro, and for promoting pluripotent stem cell derived ventral-anterior foregut spheroid tissue into 3-dimensional lung-like epithelium comprising cells having SOX9 protein activity and SOX2+ protein activity.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: January 2, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jason Spence, Alyssa Miller
  • COMPOSITIONS AND METHODS FOR OBTAINING FUNCTIONAL BASAL-LIKE CELLS
    Publication number: 20230279348
    Abstract: The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or cells through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting functional basal-like cells from pluripotent stem cell-derived lung bud tip progenitor organoid tissue through activation of SMAD signaling via activation of TGF?1 (and/or the TGF? signaling pathway) and BMP4 (and/or the BMP signaling pathway).
    Type: Application
    Filed: April 24, 2023
    Publication date: September 7, 2023
    Inventors: Jason Spence, Alyssa Miller
  • Compositions and methods for obtaining functional basal-like cells
    Patent number: 11649434
    Abstract: The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or cells through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting functional basal-like cells from pluripotent stem cell-derived lung bud tip progenitor organoid tissue through activation of SMAD signaling via activation of TGF?1 (and/or the TGF? signaling pathway) and BMP4 (and/or the BMP signaling pathway).
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: May 16, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Jason Spence, Alyssa Miller
  • COMPOSITIONS AND METHODS FOR OBTAINING FUNCTIONAL BASAL-LIKE CELLS
    Publication number: 20200149004
    Abstract: The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or cells through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting functional basal-like cells from pluripotent stem cell-derived lung bud tip progenitor organoid tissue through activation of SMAD signaling via activation of TGF?1 (and/or the TGF?signaling pathway) and BMP4 (and/or the BMP signaling pathway).
    Type: Application
    Filed: November 8, 2019
    Publication date: May 14, 2020
    Inventors: Jason Spence, Alyssa Miller
  • COMPOSITIONS AND METHODS FOR OBTAINING 3-DIMENSIONAL LUNG-LIKE EPITHELIUM AND RELATED USES THEREOF
    Publication number: 20180344901
    Abstract: The invention disclosed herein generally relates to methods and systems for growing, expanding and/or obtaining 3-dimensional lung-like epithelium comprising cells having SOX9 protein activity and SOX2+ protein activity. In particular, the invention disclosed herein relates to methods and systems for growing human cells having SOX9 protein activity and SOX2+ protein activity in vitro, and for promoting pluripotent stem cell derived ventral-anterior foregut spheroid tissue into 3-dimensional lung-like epithelium comprising cells having SOX9 protein activity and SOX2+ protein activity.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Inventors: Jason Spence, Alyssa Miller