Patents by Inventor Amael MADEC

Amael MADEC has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250084048
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Ka enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Ka signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: October 7, 2022
    Publication date: March 13, 2025
    Inventors: Alessandro BOEZIO, Alexander M. TAYLOR, Junyi ZHANG, Kelley c. SHORTSLEEVES, Levi Charles Thomas PIERCE, Thomas H. MCLEAN, Anna KAPLAN, Amaël MADEC, Brandi M. HUDSON, Jun MA, Yue PAN, Gaetan MAERTENS, Johanne OUTIN
  • JAK2 INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20240368122
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of JAK2 enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with JAK2 signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: August 19, 2022
    Publication date: November 7, 2024
    Inventors: Lucian V. DiPietro, Ravi Kurukulasuriya, Amael Madec, Catherine A. Evans, Cary Griffin Fridrich, Rebecca Jane Swett, Alessandro Boezio, Alexander M. Taylor, Thomas H. McLean, Christopher Thomson
  • SUBSTITUTED HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF
    Publication number: 20230391769
    Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.
    Type: Application
    Filed: July 27, 2021
    Publication date: December 7, 2023
    Inventors: Volker Schulze, Anne Mengel, Adelaide Clara Faria Alvares De Lemos, Sven Christian, Ulf Bömer, Roman Hillig, Christian Lechner, Jérémie Xavier Mortier, Stefan Kaulfuss, Steven Corsello, Katarzyna Handing, Amael Madec, Laura Furst, Mrinal Shekhar, Markus Berger, Rajesha Rupaimoole, Philip Lienau, Douglas Orsi, David McKinney, Krzysztof Brezezinka
  • SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20230365554
    Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.
    Type: Application
    Filed: July 27, 2021
    Publication date: November 16, 2023
    Inventors: Volker Schulze, Anne Mengel, Adelaide Clara Faria Alvares De Lemos, Ulrike Rauh, Ulf Bömer, Roman Hillig, Christian Lechner, Jeremie Xavier G. Mortier, Detlev Sülzle, Stefan Kaulfuss, Steven Corsello, Katarzyna Handing, Alisha Caliman, Amael Madec
  • SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20230339939
    Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.
    Type: Application
    Filed: July 27, 2021
    Publication date: October 26, 2023
    Inventors: Volker Schulze, Anne Mengel, Adelaide Clara Faria Alvares De Lemos, Sven Christian, Ulf Bömer, v Hillig, Christian Lechner, Jérémie Xavier Mortier, Stefan Kaulfuss, Steven Corsello, Katarzyna Handing, Amael Madec, Laura Furst, Mrinal Shekhar, Markus Berger, Rajesha Rupaimoole, Philip Lienau, Douglas Orsi, David McKinney, Krzysztof Brezezinka
  • ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF
    Publication number: 20230322767
    Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.
    Type: Application
    Filed: July 27, 2021
    Publication date: October 12, 2023
    Inventors: Volker Schulze, Anne Mengel, Adelaide Clara Faria Alvares De Lemos, Ulrike Rauh, Ulf Bömer, Roman Hillig, Christian Lechner, Jérémie Xavier Mortier, Stefan Kaulfuss, Steven Corsello, Katarzyna Handing, Amael Madec, Laura Furst, Mrinal Shekhar, David McKinney
  • ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS
    Publication number: 20220017524
    Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit elevated expression of FOXA1 and/or FOXA1 gene targets, such as certain breast, liver and/or prostate cancers, including luminal and/or ER-positive forms of breast cancer. Three previously identified adenosine receptor antagonists, CGS-15943, MRS-1220 and SCH-58261, as well as furan ring moiety-possessing derivatives of CGS-15943 are specifically provided for killing cancer cells in a manner that appears to involve activation of the aryl hydrocarbon receptor (AHR) by such compounds. The instant disclosure therefore provides for selecting and/or administering CGS-15943, MRS-1220, SCH-58261 and/or a furan-possessing derivative of CGS-15943, MRS-1220 and/or SCH-58261 as a therapeutic agent to target a cancer cell and/or subject having or at risk of developing a cancer.
    Type: Application
    Filed: November 14, 2019
    Publication date: January 20, 2022
    Applicants: THE BROAD INSTITUTE, INC., DANA-FARBER CANCER INSTITUTE, INC., INSTITUTO CARLOS SLIM DE LA SALUD, A.C.
    Inventors: Steven CORSELLO, Ryan SPANGLER, Rohith NAGARI, Todd GOLUB, Amael MADEC