Patents by Inventor Amanda Chen

Amanda Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED TISSUE CONSTRUCTS FOR THE TREATMENT OF HYPERAMMONEMIA
    Publication number: 20260131052
    Abstract: The present disclosure provides implantable engineered tissue constructs having hepatocytes and stromal cells for the treatment of hyperammonemia.
    Type: Application
    Filed: October 25, 2022
    Publication date: May 14, 2026
    Inventors: Arnav CHHABRA, Amanda CHEN, Joseph E. MARTURANO, Keval N. VYAS, Thomas Jay LOWERY, JR., Fabiola MUNARIN
  • DEVICES AND METHODS FOR CELL ENCAPSULATION
    Publication number: 20250340831
    Abstract: Featured is a device for encapsulating cells and aggregates thereof. Also featured are methods of encapsulating aggregates including, e.g., parenchymal cells (e.g., hepatocytes) and stromal cells, in a biocompatible scaffold.
    Type: Application
    Filed: May 26, 2023
    Publication date: November 6, 2025
    Inventors: Amanda CHEN, Thomas Jay LOWERY, JR., Peter MOUA, Christopher MONTALBANO, Greg MONTALBANO, Andrew MARTIN
  • METHODS OF IMPLANTING ENGINEERED TISSUE CONSTRUCTS
    Publication number: 20240424170
    Abstract: The present disclosure provides engineered tissue constructs having a population of cells. such as hepatocytes and stromal cells. and methods of implanting the same (e.g., for treating a disease or disorder, such as acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof).
    Type: Application
    Filed: October 25, 2022
    Publication date: December 26, 2024
    Inventors: Morgan JAMIEL, Howard TAKIFF, Amanda CHEN, Arnav CHHABRA, Thomas Jay LOWERY, Alison HAYWARD, Timothy Alfred NORMAN, Laura LANDE-DINER, Joseph E. MARTURANO, Christopher Garrison WILSON, Glenn Michael LA MURAGLIA, Nikitha GADE
  • METHODS FOR AGGREGATING CELLS IN SUSPENSION
    Publication number: 20240409897
    Abstract: The invention features a method of producing aggregates of a plurality of cell populations (e.g., a first population of cells and a second population of cells). The method includes agitating a liquid medium that contains the cells in a bioreactor. These aggregates may be used for subsequent downstream applications, such as encapsulation in a biocompatible scaffold to form an engineered tissue construct.
    Type: Application
    Filed: October 25, 2022
    Publication date: December 12, 2024
    Inventors: Christopher Garrison WILSON, Marcus LEHMANN, Julie MORSE, Bridget ZHOU, Amanda CHEN, Peter MOUA, Fabiola MUNARIN, Joseph E. MARTURANO
  • INDUCIBLE TISSUE CONSTRUCTS AND USES THEREOF
    Publication number: 20240287463
    Abstract: Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided.
    Type: Application
    Filed: January 22, 2021
    Publication date: August 29, 2024
    Inventors: Christopher S. Chen, Sangeeta N. Bhatia, Arnav Chhabra, Amanda Chen, Hyun Ho Song
  • ENGINEERED TISSUE CONSTRUCTS AND USES THEREOF
    Publication number: 20240277900
    Abstract: The present disclosure provides engineered tissue constructs having hepatocytes and stromal cells and methods of making and using the same (e.g., for treating acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof). The engineered tissue constructs may provide a microenvironment that promotes the persistence of hepatocyte survival for at least three months.
    Type: Application
    Filed: April 25, 2024
    Publication date: August 22, 2024
    Inventors: Arnav CHHABRA, Amanda CHEN, Keval N. VYAS, Thomas Jay LOWERY, JR., Fabiola MUNARIN, Glenn Michael LA MURAGLIA, II, Timothy Alfred NORMAN, JR., Christopher Garrison WILSON, Joseph E. MARTURANO, Morgan JAMIEL, Alison HAYWARD, Howard TAKIFF
  • METHODS OF IMPLANTING ENGINEERED TISSUE CONSTRUCTS
    Publication number: 20230132318
    Abstract: The present disclosure provides engineered tissue constructs having a population of cells, such as hepatocytes and stromal cells, and methods of making and using the same (e.g., for treating a disease or disorder, such as acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof).
    Type: Application
    Filed: May 27, 2022
    Publication date: April 27, 2023
    Inventors: Laura LANDE-DINER, Howard TAKIFF, Amanda CHEN, Arnav CHHABRA, Thomas Jay LOWERY, JR., Morgan JAMIEL, Alison HAYWARD, Timothy Alfred NORMAN, JR., Joseph E. MARTURANO
  • INDUCIBLE TISSUE CONSTRUCTS AND USES THEREOF
    Publication number: 20210222128
    Abstract: Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided.
    Type: Application
    Filed: November 19, 2020
    Publication date: July 22, 2021
    Inventors: Christopher S. CHEN, Sangeeta N. BHATIA, Arnav CHHABRA, Amanda CHEN, Hyun Ho SONG
  • Composition comprising perlite and a polymer bearing a carbosiloxane dendrimer-based unit
    Patent number: 9572764
    Abstract: The present invention concerns a composition comprising a physiologically acceptable medium containing perlite and at least one vinyl polymer bearing at least one carbosiloxane dendrimer-based unit. The composition is used in the care of and for making up the skin, in particular to provide a matt effect.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 21, 2017
    Assignee: L'OREAL
    Inventors: Pascal Arnaud, Amanda Chen, Anne-Catherine Legros
  • COMPOSITION COMPRISING PERLITE AND A POLYMER BEARING A CARBOSILOXANE DENDRIMER-BASED UNIT
    Publication number: 20140127274
    Abstract: The present invention concerns a composition comprising a physiologically acceptable medium containing perlite and at least one vinyl polymer bearing at least one carbosiloxane dendrimer-based unit. The composition is used in the care of and for making up the skin, in particular to provide a matt effect.
    Type: Application
    Filed: March 30, 2012
    Publication date: May 8, 2014
    Applicant: L'OREAL
    Inventors: Pascal Arnaud, Amanda Chen, Anne-Catherine Legros
  • Regulation of Integrin Surface Expression
    Publication number: 20110160292
    Abstract: Disclosed are methods and compositions for preventing and treating conditions associated with platelet aggregation, comprising administering a therapeutically effective amount of a composition that modifies the interaction of DNAJC10 with ?IIb?3 in a megakaryocyte, thereby altering the expression of ?IIb?3 on the surface of the megakaryocyte.
    Type: Application
    Filed: March 7, 2011
    Publication date: June 30, 2011
    Inventors: W. Beau Mitchell, Mahmoud Yazdani Abyaneh, Amanda Chen
  • Regulation of integrin surface expression
    Patent number: 7928084
    Abstract: Disclosed are methods and compositions for preventing and treating conditions associated with platelet aggregation, comprising administering a therapeutically effective amount of a composition that modifies the interaction of DNAJC10 with ?IIb?3 in a megakaryocyte, thereby altering the expression of ?IIb?3 on the surface of the megakaryocyte.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: April 19, 2011
    Assignee: New York Blood Center, Inc.
    Inventors: W. Beau Mitchell, Mahmoud Yazdani Abyaneh, Amanda Chen
  • Regulation of Integrin Surface Expression
    Publication number: 20100048677
    Abstract: Disclosed are methods and compositions for preventing and treating conditions associated with platelet aggregation, comprising administering a therapeutically effective amount of a composition that modifies the interaction of DNAJC10 with ?IIb?3 in a megakaryocyte, thereby altering the expression of ?IIb?3 on the surface of the megakaryocyte.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 25, 2010
    Inventors: W. Beau Mitchell, Mahmoud Yazdani Abyaneh, Amanda Chen